Journal Article

Blood flow and autoregulation in somatic and autonomic ganglia. Comparison with sciatic nerve.

P G McManis, J D Schmelzer, P J Zollman and P A Low

in Brain

Published on behalf of The Guarantors of Brain

Volume 120, issue 3, pages 445-449
Published in print March 1997 | ISSN: 0006-8950
Published online March 1997 | e-ISSN: 1460-2156 | DOI: https://dx.doi.org/10.1093/brain/120.3.445
Blood flow and autoregulation in somatic and autonomic ganglia. Comparison with sciatic nerve.

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We studied blood flow rates along the sciatic nerve and in the superior cervical and L-5 dorsal root ganglia of rats at rest and during reductions and increases in mean arterial pressure induced by partial exsanguination or blood transfusion. Blood flow was measured by the tissue distribution of [14C]iodoantipyrine and autoradiography. At rest, blood flow did not vary along the peripheral nerve, but was two to three times greater in dorsal root and superior cervical ganglia. In peripheral nerve, blood flow increased with increases in blood pressure. In contrast, blood flow in dorsal root and sympathetic ganglia did not vary with changes in pressure. Thus, peripheral nerve cell bodies have greater blood flow than their axons; ganglion blood flow is autoregulated within the range of blood pressure tested. Nerve ganglia appear to be protected against ischaemic stress by autoregulation rather than by a blood flow "safety margin', as in peripheral nerve.

Keywords: Non-programmatic

Journal Article.  0 words. 

Subjects: Neurology ; Neuroscience

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