Journal Article

Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology

John D. Salamone, Samantha E. Yohn, Laura López-Cruz, Noemí San Miguel and Mercè Correa

in Brain

Published on behalf of The Guarantors of Brain

Volume 139, issue 5, pages 1325-1347
Published in print May 2016 | ISSN: 0006-8950
Published online April 2016 | e-ISSN: 1460-2156 | DOI: http://dx.doi.org/10.1093/brain/aww050
Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology

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Motivation is critical for survival, and involves multiple behavioural functions mediated by a number of interacting neural circuits. Salamone et al. review basic neuroscience research, animal models, and clinical studies focused on brain mechanisms of effort-based decision making, and also consider the origins and treatment of motivational impairments in psychopathology.

Keywords: dopamine; reward; depression; fatigue; anergia

Journal Article.  18091 words.  Illustrated.

Subjects: Neuroscience ; Neurology ; Psychiatry

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