Journal Article

Acacetin 7-O-α-l-rhamnopyranosyl (1–2) β-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in <i>Caenorhabditis elegans</i>

Jyotsna Asthana, Deepti Yadav, Aakanksha Pant, A. K. Yadav, M. M. Gupta and Rakesh Pandey

in The Journals of Gerontology: Series A

Volume 71, issue 9, pages 1160-1168
Published in print September 2016 | ISSN: 1079-5006
Published online October 2015 | e-ISSN: 1758-535X | DOI: http://dx.doi.org/10.1093/gerona/glv173
Acacetin 7-O-α-l-rhamnopyranosyl (1–2) β-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in Caenorhabditis elegans

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The advancements in the field of gerontology have unraveled the signaling pathways that regulate life span, suggesting that it might be feasible to modulate aging. To this end, we isolated a novel phytomolecule Acacetin 7-O-α-l-rhamnopyranosyl (1–2) β-D-xylopyranoside (ARX) from Premna integrifolia and evaluated its antiaging effects in Caenorhabditis elegans. The spectral data analysis revealed the occurrence of a new compound ARX. Out of the three tested pharmacological doses of ARX, viz. 5, 25, and 50 µM, the 25-µM dose was able to extend life span in C. elegans by more than 39%. The present study suggests that ARX affects bacterial metabolism, which in turn leads to dietary restriction (DR)-like effects in the worms. The effect of ARX on worms with mutations (mev-1, eat-2, sir-2.1, skn-1, daf-16, and hsf-1) indicates that ARX-mediated life-span extension involves mechanisms associated with DR and maintenance of cellular redox homeostasis. This study is the first time report on longevity-promoting activity of ARX in C. elegans mediated by stress and DR-regulating genes. This novel phytomolecule can contribute in designing therapeutics for managing aging and age-related diseases.

Keywords: Aging; Phytomolecule; Caenorhabditis elegans; Oxidative stress; Longevity.

Journal Article.  7328 words.  Illustrated.

Subjects: Geriatric Medicine ; Public Health ; Biological Sciences ; Molecular and Cell Biology ; Neuroscience

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