Chapter

Autoimmune and paraneoplastic autonomic neuropathies

Steven Vernino and Angela Vincent

in Autonomic Failure

Fifth edition

Published on behalf of Oxford University Press

Published in print May 2013 | ISBN: 9780198566342
Published online July 2013 | e-ISBN: 9780199666508 | DOI: http://dx.doi.org/10.1093/med/9780198566342.003.0054
Autoimmune and paraneoplastic autonomic neuropathies

Show Summary Details

Preview

Key points

Cancer patients may have autonomic dysfunction due to direct effects of the malignancy or due to remote effects mediated by the immune system. - Acute or subacute autonomic failure can result from an autoimmune ‘paraneoplastic’ response to tumour antigens that cross reacts with autonomic ganglia or nerves. - Paraneoplastic autonomic neuropathy can present as widespread autonomic failure or as isolated severe gastrointestinal dysmotility. - Autonomic failure can also occur as a non-paraneoplastic idiopathic autoimmune disorder specifically targeting autonomic nerves or ganglia. - Autonomic dysfunction is also commonly seen in patients with Lambert–Eaton myasthenic syndrome, autoimmune neuromyotonia or Morvan’s syndrome both with and without tumours. - Patients with autoimmune or paraneoplastic autonomic neuropathy may have specific serum autoantibodies. - Some cases of autoimmune autonomic neuropathy are caused by antibodies specific for ganglionic nicotinic acetylcholine receptors. - Experimental autoimmune animal models of autonomic neuropathy have been described.

Chapter.  8065 words.  Illustrated.

Subjects: Neurology ; Immunology

Full text: subscription required

How to subscribe Recommend to my Librarian

Buy this work at Oxford University Press »

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.