Journal Article

Diagnosis, Treatment, and Reporting of Adverse Effects of Transfusion

Richard Torres, Barton Kenney and Christopher A. Tormey

in Laboratory Medicine

Published on behalf of American Society for Clinical Pathology

Volume 43, issue 5, pages 217-231
Published in print August 2012 | ISSN: 0007-5027
Published online September 2015 | e-ISSN: 1943-7730 | DOI:
Diagnosis, Treatment, and Reporting of Adverse Effects of Transfusion

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  • Haematology
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Show Summary Details


The risks of transfusion remain significant. Familiarity with the incidence, etiology, management, and prevention of commonly encountered transfusion reactions is integral to the practice of transfusion medicine. This review intends to serve as a practical guide reflecting the current understanding of adverse transfusion events, clinical features helpful for diagnosis, and recommended management strategies for typical scenarios. Severe and mild transfusion reactions are covered, with a focus on the distinguishing features of challenging clinical dilemmas. Topics include pulmonary complications of transfusion, hemolytic reactions, allergic and anaphylactic reactions, septic reactions, and febrile responses to transfusion. We also discuss a consultative approach to evaluation and reporting of transfusion reactions.

Educational Objectives

Readers should be able to describe the incidence, pathogenesis, management, prevention, and reporting of transfusion reactions.

Keywords: transfusion reactions; adverse events transfusion; TRALI; TACO; hemolysis; sepsis

Journal Article.  8762 words.  Illustrated.

Subjects: Haematology ; Business and Management

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