A ‘one-pot’ assay for the accessibility of DNA in a nucleosome core particle
in Nucleic Acids Research
January 2004; published online January 2004.
Journal Article. Subjects: genetics and genomics; chemistry; bioinformatics and computational biology; molecular and cell biology. 3403 words.
The accessibility of nucleosomal DNA to transcription factors and other sequence-specific DNA binding proteins is of importance in the consideration of mechanisms of transcriptional control....
A 16S rRNA–tRNA product containing a nucleotide phototrimer and specific for tRNA in the P/E hybrid state in the Escherichia coli ribosome
in Nucleic Acids Research
January 2004; published online January 2004.
Journal Article. Subjects: genetics and genomics; chemistry; bioinformatics and computational biology; molecular and cell biology. 6644 words.
Ribosome complexes containing deacyl-[math] or biotinylvalyl-[math] and an mRNA analog have been irradiated with wavelengths specific for activation of the cmo5U nucleoside at position 34 in...
A 1.8 kb Alternative Transcript from the Human Epidermal Growth Factor Receptor Gene Encodes a Truncated form of the Receptor
in Nucleic Acids Research
October 1996.
Journal Article. Subjects: genetics and genomics; chemistry; bioinformatics and computational biology; molecular and cell biology. 5304 words.
The epidermal growth factor receptor (EGFR) is encoded by the c-erbB1 proto-oncogene and plays an important role in the control of cell growth and differentiation. To study the potential growth...
A 21‐amino acid peptide from the cysteine cluster II of the family D DNA polymerase from Pyrococcus horikoshii stimulates its nuclease activity which is Mre11‐like and prefers manganese ion as the cofactor
in Nucleic Acids Research
January 2004; published online January 2004.
Journal Article. Subjects: genetics and genomics; chemistry; bioinformatics and computational biology; molecular and cell biology. 7265 words.
Family D DNA polymerase (PolD) is a new type of DNA polymerase possessing polymerization and 3′–5′ exonuclease activities. Here we report the characterization of the nuclease activity of...
A 2,2′-bipyridine ligand for incorporation into oligodeoxynucleotides: Synthesis, stability and fluorescence properties of ruthenium—DNA complexes
in Nucleic Acids Research
January 1999; published online January 1999.
Journal Article. Subjects: genetics and genomics; chemistry; bioinformatics and computational biology; molecular and cell biology. 4768 words.
A non-nucleoside linker based upon the ligand 2,2′-bipyridine and ethylene glycol is prepared and placed into the backbone of a number of oligonucleo-tides. The bipyridine ligand is reacted with cis-null...
A 39 Amino Acid Fragment of the Cell Cycle Regulator p21 Is Sufficient to Bind PCNA and Partially Inhibit DNA Replication in vivo
in Nucleic Acids Research
May 1996.
Journal Article. Subjects: genetics and genomics; chemistry; bioinformatics and computational biology; molecular and cell biology. 5347 words.
The cell cycle regulator p21 interacts with and inhibits the DNA replication and repair factor proliferating cell nuclear antigen (PCNA). We have defined a 39 amino acid fragment of p21 which is...
A 3D pattern matching algorithm for DNA sequences
in Bioinformatics
March 2007; published online January 2007.
Journal Article. Subjects: bioinformatics and computational biology. 4664 words.
Motivation: Biologists usually work with textual DNA sequences (succession of A, C, G and T). This representation allows biologists to study the syntax and other linguistic properties of DNA...
A 43 kDa DNA Binding Protein from the Pea Chloroplast Interacts with and Stimulates the Cognate DNA Polymerase
in Nucleic Acids Research
October 1996.
Journal Article. Subjects: genetics and genomics; chemistry; bioinformatics and computational biology; molecular and cell biology. 7125 words.
A DNA binding protein with DNA polymerase ‘accessory activity’ has been identified and purified to apparent homogeneity from pea chloroplasts. This protein consists of a single subunit of 43 kDa and...
A 5′ Untranslated Region Which Directs Accurate and Robust Translation By Prokaryotic and Mammalian Ribosomes
in Nucleic Acids Research
March 1996.
Journal Article. Subjects: genetics and genomics; chemistry; bioinformatics and computational biology; molecular and cell biology. 1382 words.
A 7-methylguanosine cap commits U3 and U8 small nuclear RNAs to the nucleolar localization pathway
in Nucleic Acids Research
February 1998; published online February 1998.
Journal Article. Subjects: genetics and genomics; chemistry; bioinformatics and computational biology; molecular and cell biology. 3553 words.
U3 and U8 small nucleolar RNAs (snRNAs) participate in pre-rRNA processing. Like the U1, U2, U4 and U5 major spliceosomal snRNAs, U3 and U8 RNAs are transcribed by RNA polymerase II and their...