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Medicine and Health x Developmental Biology x clear all

Adolescent epigenetic profiles and environmental exposures from early life through peri-adolescence

Jaclyn M. Goodrich, Dana C. Dolinoy, Brisa N. Sánchez, Zhenzhen Zhang, John D. Meeker, Adriana Mercado-Garcia, Maritsa Solano-González, Howard Hu, Martha M. Téllez-Rojo and Karen E. Peterson.

in Environmental Epigenetics

P ublished online August 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 7573 words.

Epigenetic perturbations induced by environmental exposures at susceptible lifestages contribute to disease development. Even so, the influence of early life and ongoing exposures on the...

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Alterations in sperm DNA methylation, non-coding RNA expression, and histone retention mediate vinclozolin-induced epigenetic transgenerational inheritance of disease

Millissia Ben Maamar, Ingrid Sadler-Riggleman, Daniel Beck, Margaux McBirney, Eric Nilsson, Rachel Klukovich, Yeming Xie, Chong Tang, Wei Yan and Michael K Skinner.

Edited by Christopher Faulk.

in Environmental Epigenetics

P ublished online April 2018 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 10498 words.

Abstract

Epigenetic transgenerational inheritance of disease and phenotypic variation can be induced by several toxicants, such as vinclozolin. This phenomenon...

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Ancestral vinclozolin exposure alters the epigenetic transgenerational inheritance of sperm small noncoding RNAs

Andrew Schuster, Michael K. Skinner and Wei Yan.

in Environmental Epigenetics

P ublished online March 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 6687 words.

Exposure to the agricultural fungicide vinclozolin during gestation promotes a higher incidence of various diseases in the subsequent unexposed F3 and F4 generations. This phenomenon is...

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Biology of Reproduction

Journal. Subjects: Reproduction, Growth and Development; Reproductive Medicine; Developmental Biology; Animal Reproduction.

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Bisphenol-A and metabolic diseases: epigenetic, developmental and transgenerational basis

Paloma Alonso-Magdalena, Francisco J. Rivera and Carlos Guerrero-Bosagna.

in Environmental Epigenetics

P ublished online October 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 6177 words.

Exposure to environmental toxicants is now accepted as a factor contributing to the increasing incidence of obesity and metabolic diseases around the world. Such environmental compounds are...

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Bugs in the program: can pregnancy drugs and smoking disturb molecular reprogramming of the fetal germline, increasing heritable risk for autism and neurodevelopmental disorders?

Jill Escher.

in Environmental Epigenetics

P ublished online April 2018 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 4239 words.

Abstract

In a seeming paradox, the prevalence of autism spectrum disorder (ASD) has surged, while at the same time research has pointed to the strong...

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Comparative transcriptomic analysis of human placentae at term and preterm delivery

Alison G Paquette, Heather M Brockway, Nathan D Price and Louis J Muglia.

in Biology of Reproduction

January 2018; p ublished online December 2017 .

Journal Article. Subjects: Reproduction, Growth and Development; Reproductive Medicine; Developmental Biology; Animal Reproduction. 6974 words.

Abstract

Preterm birth affects 1 out of every 10 infants in the United States, resulting in substantial neonatal morbidity and mortality. Currently, there are...

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A cross-study analysis of prenatal exposures to environmental contaminants and the epigenome: support for stress-responsive transcription factor occupancy as a mediator of gene-specific CpG methylation patterning

Elizabeth M. Martin and Rebecca C. Fry.

in Environmental Epigenetics

P ublished online January 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 5869 words.

A biological mechanism by which exposure to environmental contaminants results in gene-specific CpG methylation patterning is currently unknown. We hypothesize that gene-specific CpG...

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Developmental origins of epigenetic transgenerational inheritance

Mark A. Hanson and Michael K. Skinner.

in Environmental Epigenetics

P ublished online March 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 5996 words.

Environmental factors can induce epigenetic alterations in the germ cells that can potentially be transmitted transgenerationally. This non-genetic form of inheritance is termed epigenetic...

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Distinct reorganization of collagen architecture in lipopolysaccharide-mediated premature cervical remodeling

Shanmugasundaram Nallasamy, Meredith Akins, Breanna Tetreault, Kate Luby-Phelps and Mala Mahendroo.

in Biology of Reproduction

January 2018; p ublished online November 2017 .

Journal Article. Subjects: Reproduction, Growth and Development; Reproductive Medicine; Developmental Biology; Animal Reproduction. 7591 words.

Abstract

Previous work has identified divergent mechanisms by which cervical remodeling is achieved in preterm birth (PTB) induced by hormone withdrawal...

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