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You are looking at 1-10 of 416 items for:

Medicine and Health x Disorders of the Nervous System x clear all

Abnormalities of fixation, saccade and pursuit in posterior cortical atrophy

Timothy J. Shakespeare, Diego Kaski, Keir X. X. Yong, Ross W. Paterson, Catherine F. Slattery, Natalie S. Ryan, Jonathan M. Schott and Sebastian J. Crutch.

in Brain

July 2015; p ublished online April 2015 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System. 9780 words.

The clinico-neuroradiological syndrome posterior cortical atrophy is the cardinal ‘visual dementia’ and most common atypical Alzheimer’s disease phenotype, offering insights into mechanisms...

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Accumulation of murine amyloid-β mimics early Alzheimer’s disease

Markus Krohn, Alexander Bracke, Yosef Avchalumov, Toni Schumacher, Jacqueline Hofrichter, Kristin Paarmann, Christina Fröhlich, Cathleen Lange, Thomas Brüning, Oliver von Bohlen und Halbach and Jens Pahnke.

in Brain

August 2015; p ublished online May 2015 .

Journal Article. Subjects: Disorders of the Nervous System; Neuropathology. 7267 words.

Amyloidosis mouse models of Alzheimer’s disease are generally established by transgenic approaches leading to an overexpression of mutated human genes that are known to be involved in the...

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Adaptive Immunity

Jessica A. L. Hutter-Saunders, Larisa Y. Poluektova, Subhash Dhawan and Howard E. Gendelman.

in The Neurology of AIDS

December 2011; p ublished online September 2012 .

Chapter. Subjects: Disorders of the Nervous System; Infectious Diseases. 15588 words.

Innate and adaptive immune responses against human immunodeficiency virus type one (HIV-1) infection parallel those seen against misfolded, aggregated and nitrated proteins during...

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Addiction

R. Douglas Bruce.

in The Neurology of AIDS

December 2011; p ublished online September 2012 .

Chapter. Subjects: Disorders of the Nervous System; Infectious Diseases. 14126 words.

Substance use disorders can increase the risk of HIV infection directly, through the sharing of needles among injection drug users, and indirectly, through facilitation of high-risk sexual...

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Adjunctive Medicines

Harris A. Gelbard and Stuart A. Lipton.

in The Neurology of AIDS

December 2011; p ublished online September 2012 .

Chapter. Subjects: Disorders of the Nervous System; Infectious Diseases. 9875 words.

Antiretroviral drugs are the only therapy currently in general use for the treatment of HIV-associated neurocognitive disorders (HAND), but the treatment response to these agents may be...

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Aging

Virawudh Soontornniyomkij and Cristian L. Achim.

in The Neurology of AIDS

December 2011; p ublished online September 2012 .

Chapter. Subjects: Disorders of the Nervous System; Infectious Diseases. 13168 words.

Dramatically improved survival due to HAART, and increases in newly diagnosed HIV infection in older adults, have lead to a growing number of older HIV+ patients. In the United States, it...

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Allogeneic haematopoietic stem cell transplantation for mitochondrial neurogastrointestinal encephalomyopathy

Joerg P. Halter, W. Michael, M. Schüpbach, Hanna Mandel, Carlo Casali, Kim Orchard, Matthew Collin, David Valcarcel, Attilio Rovelli, Massimiliano Filosto, Maria T. Dotti, Giuseppe Marotta, Guillem Pintos, Pere Barba, Anna Accarino, Christelle Ferra, Isabel Illa, Yves Beguin, Jaap A. Bakker, Jaap J. Boelens, Irenaeus F. M. de Coo, Keith Fay, Carolyn M. Sue, David Nachbaur, Heinz Zoller, Claudia Sobreira, Belinda Pinto Simoes, Simon R. Hammans, David Savage, Ramon Martí, Patrick F. Chinnery, Ronit Elhasid, Alois Gratwohl and Michio Hirano.

in Brain

October 2015; p ublished online August 2015 .

Journal Article. Subjects: Sensory and Motor Systems; Disorders of the Nervous System; Neuropathology. 6101 words.

Haematopoietic stem cell transplantation has been proposed as treatment for mitochondrial neurogastrointestinal encephalomyopathy, a rare fatal autosomal recessive disease due to TYMP mutat...

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Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency

Dewei Jiang, Ying Zhang, Ronald P. Hart, Jianmin Chen, Karl Herrup and Jiali Li.

in Brain

December 2015; p ublished online October 2015 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System. 8858 words.

A long-standing mystery surrounding ataxia-telangiectasia is why it is mainly cerebellar neurons, Purkinje cells in particular, that appear vulnerable to ATM deficiency. Here we present...

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Alterations in the hypothalamic melanocortin pathway in amyotrophic lateral sclerosis

Pauline Vercruysse, Jérôme Sinniger, Hajer El Oussini, Jelena Scekic-Zahirovic, Stéphane Dieterlé, Reinhard Dengler, Thomas Meyer, Stephan Zierz, Jan Kassubek, Wilhelm Fischer, Jens Dreyhaupt, Torsten Grehl, Andreas Hermann, Julian Grosskreutz, Anke Witting, Ludo Van Den Bosch, Odile Spreux-Varoquaux, Albert C. Ludolph and Luc Dupuis.

in Brain

April 2016; p ublished online March 2016 .

Journal Article. Subjects: Sensory and Motor Systems; Neuropathology; Disorders of the Nervous System. 8567 words.

Amyotrophic lateral sclerosis, the most common adult-onset motor neuron disease, leads to death within 3 to 5 years after onset. Beyond progressive motor impairment, patients with...

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Altered PDE10A expression detectable early before symptomatic onset in Huntington’s disease

Flavia Niccolini, Salman Haider, Tiago Reis Marques, Nils Muhlert, Andri C. Tziortzi, Graham E. Searle, Sridhar Natesan, Paola Piccini, Shitij Kapur, Eugenii A. Rabiner, Roger N. Gunn, Sarah J. Tabrizi and Marios Politis.

in Brain

October 2015; p ublished online July 2015 .

Journal Article. Subjects: Sensory and Motor Systems; Disorders of the Nervous System; Neuropathology. 8891 words.

There is an urgent need for early biomarkers and novel disease-modifying therapies in Huntington’s disease. Huntington’s disease pathology involves the toxic effect of mutant huntingtin...

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