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Medicine and Health x Sensory and Motor Systems x clear all

Allogeneic haematopoietic stem cell transplantation for mitochondrial neurogastrointestinal encephalomyopathy

Joerg P. Halter, W. Michael, M. Schüpbach, Hanna Mandel, Carlo Casali, Kim Orchard, Matthew Collin, David Valcarcel, Attilio Rovelli, Massimiliano Filosto, Maria T. Dotti, Giuseppe Marotta, Guillem Pintos, Pere Barba, Anna Accarino, Christelle Ferra, Isabel Illa, Yves Beguin, Jaap A. Bakker, Jaap J. Boelens, Irenaeus F. M. de Coo, Keith Fay, Carolyn M. Sue, David Nachbaur, Heinz Zoller, Claudia Sobreira, Belinda Pinto Simoes, Simon R. Hammans, David Savage, Ramon Martí, Patrick F. Chinnery, Ronit Elhasid, Alois Gratwohl and Michio Hirano.

in Brain

October 2015; p ublished online August 2015 .

Journal Article. Subjects: Sensory and Motor Systems; Disorders of the Nervous System; Neuropathology. 6101 words.

Haematopoietic stem cell transplantation has been proposed as treatment for mitochondrial neurogastrointestinal encephalomyopathy, a rare fatal autosomal recessive disease due to TYMP mutat...

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Alterations in the hypothalamic melanocortin pathway in amyotrophic lateral sclerosis

Pauline Vercruysse, Jérôme Sinniger, Hajer El Oussini, Jelena Scekic-Zahirovic, Stéphane Dieterlé, Reinhard Dengler, Thomas Meyer, Stephan Zierz, Jan Kassubek, Wilhelm Fischer, Jens Dreyhaupt, Torsten Grehl, Andreas Hermann, Julian Grosskreutz, Anke Witting, Ludo Van Den Bosch, Odile Spreux-Varoquaux, Albert C. Ludolph and Luc Dupuis.

in Brain

April 2016; p ublished online March 2016 .

Journal Article. Subjects: Sensory and Motor Systems; Neuropathology; Disorders of the Nervous System. 8567 words.

Amyotrophic lateral sclerosis, the most common adult-onset motor neuron disease, leads to death within 3 to 5 years after onset. Beyond progressive motor impairment, patients with...

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Altered PDE10A expression detectable early before symptomatic onset in Huntington’s disease

Flavia Niccolini, Salman Haider, Tiago Reis Marques, Nils Muhlert, Andri C. Tziortzi, Graham E. Searle, Sridhar Natesan, Paola Piccini, Shitij Kapur, Eugenii A. Rabiner, Roger N. Gunn, Sarah J. Tabrizi and Marios Politis.

in Brain

October 2015; p ublished online July 2015 .

Journal Article. Subjects: Sensory and Motor Systems; Disorders of the Nervous System; Neuropathology. 8891 words.

There is an urgent need for early biomarkers and novel disease-modifying therapies in Huntington’s disease. Huntington’s disease pathology involves the toxic effect of mutant huntingtin...

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Anti-ganglioside antibodies are removed from circulation in mice by neuronal endocytosis

Madeleine E. Cunningham, Rhona McGonigal, Gavin R. Meehan, Jennifer A. Barrie, Denggao Yao, Susan K. Halstead and Hugh J. Willison.

in Brain

June 2016; p ublished online March 2016 .

Journal Article. Subjects: Sensory and Motor Systems; Neuropathology; Disorders of the Nervous System. 4732 words.

See van Doorn and Jacobs (doi:10.1093/brain/aww078) for a scientific commentary on this article.  

In axonal forms of Guillain-Barré syndrome,...

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Anti-Jo-1 antibody-positive patients show a characteristic necrotizing perifascicular myositis

Lénaig Mescam-Mancini, Yves Allenbach, Baptiste Hervier, Hervé Devilliers, Kuberaka Mariampillay, Odile Dubourg, Thierry Maisonobe, Romain Gherardi, Paulette Mezin, Corinna Preusse, Werner Stenzel and Olivier Benveniste.

in Brain

September 2015; p ublished online July 2015 .

Journal Article. Subjects: Sensory and Motor Systems; Neuropathology; Disorders of the Nervous System. 3656 words.

Idiopathic inflammatory myopathies can be classified as polymyositis, dermatomyositis, immune-mediated necrotizing myopathy, sporadic inclusion body myositis or non-specific myositis....

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Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s disease

Joseph J. Locascio, Shirley Eberly, Zhixiang Liao, Ganqiang Liu, Ashley N. Hoesing, Karen Duong, Ana Trisini-Lipsanopoulos, Kaltra Dhima, Albert Y. Hung, Alice W. Flaherty, Michael A. Schwarzschild, Michael T. Hayes, Anne-Marie Wills, U. Shivraj Sohur, Nicte I. Mejia, Dennis J. Selkoe, David Oakes, Ira Shoulson, Xianjun Dong, Ken Marek, Bin Zheng, Adrian Ivinson, Bradley T. Hyman, John H. Growdon, Lewis R. Sudarsky, Michael G. Schlossmacher, Bernard Ravina and Clemens R. Scherzer.

in Brain

September 2015; p ublished online July 2015 .

Journal Article. Subjects: Neuropathology; Sensory and Motor Systems; Disorders of the Nervous System. 8385 words.

There are no cures for neurodegenerative diseases and this is partially due to the difficulty of monitoring pathogenic molecules in patients during life. The Parkinson’s disease gene...

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Association of inclusion body myositis with T cell large granular lymphocytic leukaemia

Steven A. Greenberg, Jack L. Pinkus, Anthony A. Amato, Thomas Kristensen and David M. Dorfman.

in Brain

May 2016; p ublished online February 2016 .

Journal Article. Subjects: Sensory and Motor Systems; Neuropathology; Disorders of the Nervous System. 5636 words.

See Hohlfeld and Schulze-Koops (doi:10.1093/brain/aww053) for a scientific commentary on this article.

Inclusion body myositis and T cell large granular...

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Astrocytic TYMP and VEGFA drive blood–brain barrier opening in inflammatory central nervous system lesions

Candice Chapouly, Azeb Tadesse Argaw, Sam Horng, Kamilah Castro, Jingya Zhang, Linnea Asp, Hannah Loo, Benjamin M. Laitman, John N. Mariani, Rebecca Straus Farber, Elena Zaslavsky, German Nudelman, Cedric S. Raine and Gareth R. John.

in Brain

June 2015; p ublished online March 2015 .

Journal Article. Subjects: Sensory and Motor Systems; Neuropathology; Disorders of the Nervous System. 11915 words.

In inflammatory central nervous system conditions such as multiple sclerosis, breakdown of the blood–brain barrier is a key event in lesion pathogenesis, predisposing to oedema,...

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Asymmetries of amyloid-β burden and neuronal dysfunction are positively correlated in Alzheimer’s disease

Lars Frings, Sabine Hellwig, Timo S. Spehl, Tobias Bormann, Ralph Buchert, Werner Vach, Lora Minkova, Bernhard Heimbach, Stefan Klöppel and Philipp T. Meyer.

in Brain

October 2015; p ublished online August 2015 .

Journal Article. Subjects: Sensory and Motor Systems; Disorders of the Nervous System; Neuropathology. 5979 words.

Clinical Alzheimer’s disease affects both cerebral hemispheres to a similar degree in clinically typical cases. However, in atypical variants like logopenic progressive aphasia,...

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Atomoxetine restores the response inhibition network in Parkinson’s disease

Charlotte L. Rae, Cristina Nombela, Patricia Vázquez Rodríguez, Zheng Ye, Laura E. Hughes, P. Simon Jones, Timothy Ham, Timothy Rittman, Ian Coyle-Gilchrist, Ralf Regenthal, Barbara J. Sahakian, Roger A. Barker, Trevor W. Robbins and James B. Rowe.

in Brain

August 2016; p ublished online June 2016 .

Journal Article. Subjects: Neuropathology; Sensory and Motor Systems; Disorders of the Nervous System. 10295 words.

Parkinson’s disease impairs the inhibition of responses, and whilst impulsivity is mild for some patients, severe impulse control disorders affect ∼10% of cases. Based on preclinical models...

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