Autonomic Failure
May 2013; p ublished online July 2013 .
Book. Subjects: Neurology; Anatomy; Urology; Respiratory Medicine and Pulmonology; Gastroenterology; Nephrology; Pain Medicine; Cardiovascular Medicine; Ophthalmology; Reproductive Medicine; Immunology; Endocrinology and Diabetes; Paediatrics; Geriatric Medicine; Anaesthetics; Pharmacology; Medical Toxicology; Surgery. 928 pages.
This new edition of Autonomic Failure features numerous new chapters and makes diagnosis increasingly precise by fully evaluating the underlying anatomical and functional deficits, thereby...
Developmental Treatment with Ethinyl Estradiol, but Not Bisphenol A, Causes Alterations in Sexually Dimorphic Behaviors in Male and Female Sprague Dawley Rats
in Toxicological Sciences
August 2014; p ublished online August 2014 .
Journal Article. Subjects: Medical Toxicology; Reproduction, Growth and Development. 14490 words.
The developing central nervous system may be particularly sensitive to bisphenol A (BPA)-induced alterations. Here, pregnant Sprague Dawley rats (n = 11–12/group) were gavaged daily with...
Identification of Drosophila-Based Endpoints for the Assessment and Understanding of Xenobiotic-Mediated Male Reproductive Adversities
in Toxicological Sciences
September 2014; p ublished online September 2014 .
Journal Article. Subjects: Medical Toxicology; Reproduction, Growth and Development. 9288 words.
Men are at risk of becoming completely infertile due to innumerable environmental chemicals and pollutants. These xenobiotics, hence, should be tested for their potential adverse effects on...
<i>In Utero</i> Exposure to TCDD Alters Wnt Signaling During Mouse Prostate Development: Linking Ventral Prostate Agenesis to Downregulated β-Catenin Signaling
in Toxicological Sciences
September 2014; p ublished online September 2014 .
Journal Article. Subjects: Medical Toxicology; Reproduction, Growth and Development. 7364 words.
In utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes ventral prostate agenesis in C57BL/6J mice by preventing ventral prostatic budding in the embryonic...
Investigation of the Effects of Subchronic Low Dose Oral Exposure to Bisphenol A (BPA) and Ethinyl Estradiol (EE) on Estrogen Receptor Expression in the Juvenile and Adult Female Rat Hypothalamus
in Toxicological Sciences
July 2014; p ublished online April 2014 .
Journal Article. Subjects: Medical Toxicology; Reproduction, Growth and Development. 9541 words.
Concerns have been raised regarding the long-term impacts of early life exposure to the ubiquitous environmental contaminant bisphenol A (BPA) on brain organization. Because BPA has been...
Ovarian Xenobiotic Biotransformation Enzymes Are Altered During Phosphoramide Mustard-Induced Ovotoxicity
in Toxicological Sciences
October 2014; p ublished online October 2014 .
Journal Article. Subjects: Medical Toxicology; Reproduction, Growth and Development. 6980 words.
The anti-neoplastic prodrug, cyclophosphamide, requires biotransformation to phosphoramide mustard (PM), which partitions to volatile chloroethylaziridine (CEZ). PM and CEZ are...
Response to Hunt <i>et al.</i>, Invalid Controls Undermine Conclusions of FDA Studies
in Toxicological Sciences
September 2014; p ublished online May 2014 .
Journal Article. Subjects: Medical Toxicology; Reproduction, Growth and Development. 709 words.
A Short-term <i>In Vivo</i> Screen Using Fetal Testosterone Production, a Key Event in the Phthalate Adverse Outcome Pathway, to Predict Disruption of Sexual Differentiation
in Toxicological Sciences
August 2014; p ublished online August 2014 .
Journal Article. Subjects: Medical Toxicology; Reproduction, Growth and Development. 10791 words.
This study was designed to develop and validate a short-term in vivo protocol termed the Fetal Phthalate Screen (FPS) to detect phthalate esters (PEs) and other chemicals that disrupt fetal...
Simvastatin and Dipentyl Phthalate Lower <i>Ex Vivo</i> Testicular Testosterone Production and Exhibit Additive Effects on Testicular Testosterone and Gene Expression Via Distinct Mechanistic Pathways in the Fetal Rat
in Toxicological Sciences
October 2014; p ublished online October 2014 .
Journal Article. Subjects: Medical Toxicology; Reproduction, Growth and Development. 7439 words.
Sex differentiation of the male reproductive tract in mammals is driven, in part, by fetal androgen production. In utero, some phthalate esters (PEs) alter fetal Leydig cell...
Target Organ Specific Activity of Drosophila MRP (ABCC1) Moderates Developmental Toxicity of Methylmercury
in Toxicological Sciences
August 2014; p ublished online August 2014 .
Journal Article. Subjects: Medical Toxicology; Reproduction, Growth and Development. 7017 words.
Methylmercury (MeHg) is a ubiquitous and persistent neurotoxin that poses a risk to human health. Although the mechanisms of MeHg toxicity are not fully understood, factors that contribute...
