A 21st Century Paradigm for Evaluating the Health Hazards of Nanoscale Materials?
in Toxicological Sciences
August 2009; p ublished online May 2009 .
Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 2385 words.
Over the past 5 years we have seen an increase in the attention focused on the assessment of the potential health risk posed by nanoscale materials. The diversity of these materials with...
A 28-Day Oral Dose Toxicity Study Enhanced to Detect Endocrine Effects of Hexabromocyclododecane in Wistar Rats
in Toxicological Sciences
December 2006; p ublished online September 2006 .
Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 8809 words.
A 28-day repeated dose study in rats (OECD407) enhanced for endocrine and immune parameters was performed with hexabromocyclododecane (HBCD). Rats were exposed by daily gavage to HBCD...
A 2-Year Comparison Study of Crl:CD BR and Hsd:Sprague-Dawley SD Rats
in Toxicological Sciences
October 1996; p ublished online October 1996 .
Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.
In this 2-year study, the suitability of the Hsd:Sprague-Dawley SD (SD) as a replacement for the Crl:CD BR (CD) rat was assessed by comparing survival rates, palpable mass incidence, body...
A 3D Human Airway Model Enables Prediction of Respiratory Toxicity of Inhaled Drugs <i>In Vitro</i>
in Toxicological Sciences
March 2018; p ublished online November 2017 .
Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 5401 words.
Abstract
Respiratory tract toxicity represents a significant cause of attrition of inhaled drug candidates targeting respiratory diseases. One of the key...
A 90-Day Chloroform Inhalation Study in F-344 Rats: Profile of Toxicity and Relevance to Cancer Studies
in Toxicological Sciences
July 1996; p ublished online July 1996 .
Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.
Composition of diet may influence growth, diseases, tumor rates, and responses to chemical treatment. Since 1980 the NIH–07 open formula nonpurified diet has been the selected diet for the...
A 90-Day Chloroform Inhalation Study in Female and Male B6C3F<sub>1</sub> Mice: Implications for Cancer Risk Assessment
in Toxicological Sciences
March 1996; p ublished online March 1996 .
Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.
High doses of chloroform induced liver cancer in male and female B6C3F1 mice when administered by gavage, kidney cancer in male Osborne-Mendel rats when given by gavage or in the drinking...
A 90-Day Drinking Water Toxicity Study in Rats of the Environmental Contaminant Ammonium Perchlorate
in Toxicological Sciences
September 2000; p ublished online September 2000 .
Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 9519 words.
Perchlorate (ClO– 4), the dissociated anion of perchlorate salts such as ammonium, potassium, and sodium perchlorate, has been recently recognized as a persistent and pervasive...
A 90-Day Toxicological Evaluation of Compound 1080 (Sodium Monofluoroacetate) in Sprague-Dawley Rats
in Toxicological Sciences
October 2002; p ublished online October 2002 .
Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 7262 words.
Groups of Sprague-Dawley rats received sodium monofluoroacetate (Compound 1080) at 0.025, 0.075, and 0.25 mg/kg by oral gavage once daily for 90 days and were then euthanized. The control...
A2 (<i>N</i>-Benzylpiperazine) a New Drug of Abuse in Sweden
in Journal of Analytical Toxicology
January 2004; p ublished online January 2004 .
Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.
N-Benzylpiperazine was tested in the beginning of the 1970s as a possible antidepressant drug. However, in both animal and human studies, it was shown to possess...
ABCB1 Protects Kidney Proximal Tubule Cells Against Cadmium-Induced Apoptosis: Roles of Cadmium and Ceramide Transport
in Toxicological Sciences
June 2011; p ublished online March 2011 .
Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 6754 words.
Cadmium (Cd2+) damages the kidney proximal tubule (PT) by ceramide-dependent apoptosis and is also a class I carcinogen. Multidrug resistance P-glycoprotein (MDR1, ABCB1) confers resistance...
