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Antibodies

Anthony Rees.

in The Antibody Molecule

October 2014; p ublished online March 2015 .

Chapter. Subjects: Immunology; Haematology. 2538 words.

In this short ‘prospective’ the author suggest directions, currently poorly targeted by the academic and commercial research and development communities, that antibody-related therapies may...

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Antibody engineering

Anthony Rees.

in The Antibody Molecule

October 2014; p ublished online March 2015 .

Chapter. Subjects: Immunology; Haematology. 13295 words.

Evolving the antibody phenotypic repertoire by protein engineering has opened up extraordinary possibilities for defeating many infectious diseases, cancer, haemolytic disorders, and even...

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The Antibody Molecule

Anthony R. Rees.

October 2014; p ublished online March 2015 .

Book. Subjects: Immunology; Haematology. 384 pages.

The Antibody Molecule follows the extraordinary journey of the medics and scientists who shaped the course of medical advances in the field of immunology. One of the oldest of the medical...

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Antibody pre-history

Anthony Rees.

in The Antibody Molecule

October 2014; p ublished online March 2015 .

Chapter. Subjects: Immunology; Haematology. 7381 words.

In this chapter, the early vaccination experiments of Jenner together with the careful experimentation of Robert Koch leading to his famous ‘postulates’; the often combative relationships...

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Antibody structure prediction and development of humanization strategies

Anthony Rees.

in The Antibody Molecule

October 2014; p ublished online March 2015 .

Chapter. Subjects: Immunology; Haematology. 13624 words.

With more than a million antibodies in the human repertoire, the determination of the three-dimensional structures of all functionally interesting antibodies is an improbable task. To avoid...

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Autoimmune haematological disorders

Gavin P Spickett.

in Oxford Handbook of Clinical Immunology and Allergy

April 2013; p ublished online February 2013 .

Chapter. Subjects: Immunology; Haematology. 2193 words.

Immune thrombocytopenia (ITP) - Autoimmune haemolytic anaemia - Autoimmune neutropenia - Paroxysmal nocturnal haemoglobinuria (PNH) - Aplastic anaemia (AA) and pure red cell...

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The cellular reformation

Anthony Rees.

in The Antibody Molecule

October 2014; p ublished online March 2015 .

Chapter. Subjects: Immunology; Haematology. 5411 words.

By the beginning of the 1950s, exactly how antibodies recognized antigens and how they were produced in such variety were still largely unknown. This would change with the revolutionary...

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Effector functions of constant regions

Anthony Rees.

in The Antibody Molecule

October 2014; p ublished online March 2015 .

Chapter. Subjects: Immunology; Haematology. 14503 words.

In order to mediate antibody functional effects after antigen binding, such as antigen clearance or mobilization of assistance from immune proteins or helper cells, specific segments of...

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The foundations of antibody-antigen recognition emerge

Anthony Rees.

in The Antibody Molecule

October 2014; p ublished online March 2015 .

Chapter. Subjects: Immunology; Haematology. 10612 words.

The structure and properties of proteins were still clouded in uncertainty during the 1930s. Theories abounded in the absence of definitive experimental information. During the decade from...

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Immunoglobulin constant regions

Anthony Rees.

in The Antibody Molecule

October 2014; p ublished online March 2015 .

Chapter. Subjects: Immunology; Haematology. 12955 words.

Antibodies not only have recognition sites for antigens, characterized by regions of high variability in the antibody variable regions, but also contain constant regions. Furthermore,...

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