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Pathology x Neurology x Histopathology x clear all

Adult Brainstem Gliomas With H3K27M Mutation: Radiology, Pathology, and Prognosis

Elena V Daoud, Veena Rajaram, Chunyu Cai, Robert J Oberle, Gregory R Martin, Jack M Raisanen, Charles L White, Chan Foong, Bruce E Mickey, Edward Pan and Kimmo J Hatanpaa.

in Journal of Neuropathology & Experimental Neurology

April 2018; p ublished online February 2018 .

Journal Article. Subjects: Neurology; Clinical Neuroscience; Pathology; Histopathology. 4782 words.

Abstract

Adult brainstem gliomas are difficult to classify based on radiologic and histologic features. A K27M mutation in histone 3 has been described to...

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Autobiography Series: In Search of Knowledge and Joy: My Life as a Neuropathologist

Samuel K Ludwin.

in Journal of Neuropathology & Experimental Neurology

February 2018; p ublished online December 2017 .

Journal Article. Subjects: Neurology; Clinical Neuroscience; Pathology; Histopathology. 8062 words.

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Central Nervous System Germinomas Express Programmed Death Ligand 1

Miriam E Wildeman, Matthew J Shepard, Edward H Oldfield and M Beatriz S Lopes.

in Journal of Neuropathology & Experimental Neurology

April 2018; p ublished online February 2018 .

Journal Article. Subjects: Neurology; Clinical Neuroscience; Pathology; Histopathology. 2769 words.

Abstract

Immunomodulation and tumor-induced tolerance is one of the central mechanisms in the oncogenesis of malignant and benign neoplasms. While numerous...

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Combination Treatment With Exogenous GDNF and Fetal Spinal Cord Cells Results in Better Motoneuron Survival and Functional Recovery After Avulsion Injury With Delayed Root Reimplantation

Carolin Ruven, Smaranda-Ruxandra Badea, Wai-Man Wong and Wutian Wu.

in Journal of Neuropathology & Experimental Neurology

April 2018; p ublished online February 2018 .

Journal Article. Subjects: Neurology; Clinical Neuroscience; Pathology; Histopathology. 11076 words.

Abstract

When spinal roots are torn off from the spinal cord, both the peripheral and central nervous system get damaged. As the motoneurons lose their axons,...

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Discrepancy Between Low Levels of mTOR Activity and High Levels of P-S6 in Primary Central Nervous System Lymphoma May Be Explained by PAS Domain-Containing Serine/Threonine-Protein Kinase-Mediated Phosphorylation

Dóra Marosvári, Noémi Nagy, Csilla Kriston, Beáta Deák, Melinda Hajdu, Csaba Bödör, Irén Csala, Attila G Bagó, Zoltán Szállási, Anna Sebestyén and Lilla Reiniger.

in Journal of Neuropathology & Experimental Neurology

April 2018; p ublished online January 2018 .

Journal Article. Subjects: Neurology; Clinical Neuroscience; Pathology; Histopathology. 3563 words.

Abstract

The primary aim of this study was to determine mTOR-pathway activity in primary central nervous system lymphoma (PCNSL), which could be a potential...

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In This Issue

in Journal of Neuropathology & Experimental Neurology

February 2018; p ublished online January 2018 .

Journal Article. Subjects: Neurology; Clinical Neuroscience; Pathology; Histopathology. 425 words.

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In This Issue

in Journal of Neuropathology & Experimental Neurology

April 2018; p ublished online March 2018 .

Journal Article. Subjects: Neurology; Clinical Neuroscience; Pathology; Histopathology. 628 words.

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Intravenous Administration of a MTMR2-Encoding AAV Vector Ameliorates the Phenotype of Myotubular Myopathy in Mice

Nathalie Danièle, Christelle Moal, Laura Julien, Martina Marinello, Thibaud Jamet, Samia Martin, Alban Vignaud, Michael W Lawlor and Ana Buj-Bello.

in Journal of Neuropathology & Experimental Neurology

April 2018; p ublished online February 2018 .

Journal Article. Subjects: Neurology; Clinical Neuroscience; Pathology; Histopathology. 7886 words.

Abstract

X-linked myotubular myopathy (XLMTM) is a severe congenital disorder in male infants that leads to generalized skeletal muscle weakness and is...

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Loss of Motor Neurons Innervating Cervical Muscles in Patients With Multiple System Atrophy and Dropped Head

Rie Saito, Mari Tada, Yasuko Toyoshima, Masatoyo Nishizawa, Osamu Onodera, Hitoshi Takahashi and Akiyoshi Kakita.

in Journal of Neuropathology & Experimental Neurology

April 2018; p ublished online February 2018 .

Journal Article. Subjects: Neurology; Clinical Neuroscience; Pathology; Histopathology. 4133 words.

Abstract

We investigated whether loss of motor neurons innervating the neck muscles contributes to dropped head (DH) in multiple system atrophy (MSA). From 75...

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Multiple Proteinopathies in Familial ALS Cases With <i>Optineurin</i> Mutations

Takashi Ayaki, Hidefumi Ito, Osamu Komure, Masaki Kamada, Masataka Nakamura, Reika Wate, Hirofumi Kusaka, Yuko Yamaguchi, Fangzhou Li, Hideshi Kawakami, Makoto Urushitani and Ryosuke Takahashi.

in Journal of Neuropathology & Experimental Neurology

February 2018; p ublished online December 2017 .

Journal Article. Subjects: Neurology; Clinical Neuroscience; Pathology; Histopathology. 3928 words.

Abstract

Optineurin (OPTN) is a causative gene in familial amyotrophic lateral sclerosis (ALS) with transactivation response element DNA-binding...

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