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Autobiography Series: In Search of Knowledge and Joy: My Life as a Neuropathologist

Samuel K Ludwin.

in Journal of Neuropathology & Experimental Neurology

February 2018; p ublished online December 2017 .

Journal Article. Subjects: Neurology; Clinical Neuroscience; Pathology; Histopathology. 8062 words.

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In This Issue

in Journal of Neuropathology & Experimental Neurology

February 2018; p ublished online January 2018 .

Journal Article. Subjects: Neurology; Clinical Neuroscience; Pathology; Histopathology. 425 words.

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Multiple Proteinopathies in Familial ALS Cases With <i>Optineurin</i> Mutations

Takashi Ayaki, Hidefumi Ito, Osamu Komure, Masaki Kamada, Masataka Nakamura, Reika Wate, Hirofumi Kusaka, Yuko Yamaguchi, Fangzhou Li, Hideshi Kawakami, Makoto Urushitani and Ryosuke Takahashi.

in Journal of Neuropathology & Experimental Neurology

February 2018; p ublished online December 2017 .

Journal Article. Subjects: Neurology; Clinical Neuroscience; Pathology; Histopathology. 3928 words.

Abstract

Optineurin (OPTN) is a causative gene in familial amyotrophic lateral sclerosis (ALS) with transactivation response element DNA-binding...

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Nerve Biopsy Is Still Useful in Some Inherited Neuropathies

Mathilde Duchesne, Stéphane Mathis, Laurence Richard, Corinne Magdelaine, Philippe Corcia, Sonia Nouioua, Meriem Tazir, Laurent Magy and Jean-Michel Vallat.

in Journal of Neuropathology & Experimental Neurology

February 2018; p ublished online December 2017 .

Journal Article. Subjects: Neurology; Clinical Neuroscience; Pathology; Histopathology. 7127 words.

Abstract

In hereditary neuropathies, next-generation sequencing techniques are producing a vast number of candidate gene mutations that need to be verified or...

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PRES: Review of Histological Features

Nicholas Willard, Justin M Honce and B K Kleinschmidt-DeMasters.

in Journal of Neuropathology & Experimental Neurology

February 2018; p ublished online December 2017 .

Journal Article. Subjects: Neurology; Clinical Neuroscience; Pathology; Histopathology. 7418 words.

Abstract

Posterior reversible encephalopathy syndrome was described in 1996 as a clinical-neuroimaging entity characterized by parieto-occipital...

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Protein Phosphatase 2A and Its Methylation Modulating Enzymes LCMT-1 and PME-1 Are Dysregulated in Tauopathies of Progressive Supranuclear Palsy and Alzheimer Disease

Hye-Jin Park, Kang-Woo Lee, Stephanie Oh, Run Yan, Jie Zhang, Thomas G Beach, Charles H Adler, Michael Voronkov, Steven P Braithwaite, Jeffry B Stock and M Maral Mouradian.

in Journal of Neuropathology & Experimental Neurology

February 2018; p ublished online December 2017 .

Journal Article. Subjects: Neurology; Clinical Neuroscience; Pathology; Histopathology. 6609 words.

Abstract

Hyperphosphorylated tau aggregates are characteristic of tauopathies including progressive supranuclear palsy (PSP) and Alzheimer disease (AD), but...

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Selective Vulnerability of Brainstem Nuclei in Distinct Tauopathies: A Postmortem Study

Rana A Eser, Alexander J Ehrenberg, Cathrine Petersen, Sara Dunlop, Maria B Mejia, Claudia K Suemoto, Christine M Walsh, Hima Rajana, Jun Oh, Panos Theofilas, William W Seeley, Bruce L Miller, Thomas C Neylan, Helmut Heinsen and Lea T Grinberg.

in Journal of Neuropathology & Experimental Neurology

February 2018; p ublished online January 2018 .

Journal Article. Subjects: Neurology; Clinical Neuroscience; Pathology; Histopathology. 7833 words.

Abstract

The brainstem nuclei of the reticular formation (RF) are critical for regulating homeostasis, behavior, and cognition. RF degenerates in tauopathies...

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Type, Frequency, and Spatial Distribution of Immune Cell Infiltrates in CNS Germinomas: Evidence for Inflammatory and Immunosuppressive Mechanisms

Pia Zapka, Evelyn Dörner, Verena Dreschmann, Noriaki Sakamato, Glen Kristiansen, Gabriele Calaminus, Christian Vokuhl, Ivo Leuschner and Torsten Pietsch.

in Journal of Neuropathology & Experimental Neurology

February 2018; p ublished online December 2017 .

Journal Article. Subjects: Neurology; Clinical Neuroscience; Pathology; Histopathology. 4422 words.

Abstract

Central nervous system germinomas are characterized by a massive immune cell infiltrate. We systematically characterized these immune cells in 28...

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