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Pathology x Research Methods in Life Sciences x clear all

Biopsy-derived Intestinal Epithelial Cell Cultures for Pathway-based Stratification of Patients With Inflammatory Bowel Disease

Wiebe Vanhove, Kris Nys, Ingrid Arijs, Isabelle Cleynen, Manuel Noben, Sebastiaan De Schepper, Gert Van Assche, Marc Ferrante and Séverine Vermeire.

in Journal of Crohn's and Colitis

January 2018; p ublished online September 2017 .

Journal Article. Subjects: Pathology; Physiology; Research Methods in Life Sciences. 6507 words.

Abstract

Background

Endoplasmic reticulum [ER] stress was shown to be pivotal in the pathogenesis of inflammatory...

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CD16<sup>+</sup> Macrophages Mediate Fibrosis in Inflammatory Bowel Disease

Pedro Salvador, Dulce Carolina Macías-Ceja, Laura Gisbert-Ferrándiz, Carlos Hernández, David Bernardo, Rafael Alós, Francisco Navarro-Vicente, Juan Vicente Esplugues, Dolores Ortiz-Masiá, Maria Dolores Barrachina and Sara Calatayud.

in Journal of Crohn's and Colitis

April 2018; p ublished online January 2018 .

Journal Article. Subjects: Pathology; Physiology; Research Methods in Life Sciences. 5609 words.

Abstract

Background and Aims

Fibrosis is a common complication of Crohn’s disease [CD], and is related to...

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Effect of PF-00547659 on Central Nervous System Immune Surveillance and Circulating β7+ T Cells in Crohn’s Disease: Report of the TOSCA Study

Geert D’Haens, Séverine Vermeire, Harald Vogelsang, Matthieu Allez, Pierre Desreumaux, Andre Van Gossum, William J Sandborn, Daniel C Baumgart, Richard M Ransohoff, Gail M Comer, Alaa Ahmad, Fabio Cataldi, John Cheng, Robert Clare, Kenneth J Gorelick, Annamarie Kaminski, Vivek Pradhan, Sunday Rivers, Matthew O Sikpi, Yanhua Zhang, Mina Hassan-Zahraee, Walter Reinisch and Olaf Stuve.

in Journal of Crohn's and Colitis

January 2018; p ublished online September 2017 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Gastroenterology; Pathology; Physiology; Research Methods in Life Sciences. 5592 words.

Abstract

Background and Aims

Progressive multifocal leukoencephalopathy [PML], a brain infection associated with...

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Genomic and Expression Analyses Identify a Disease-Modifying Variant for Fibrostenotic Crohn’s Disease

Marijn C Visschedijk, Lieke M Spekhorst, Shih-Chin Cheng, Ellen S van Loo, B H Dianne Jansen, Tjasso Blokzijl, Hyunsuk Kil, Dirk J de Jong, Marieke Pierik, Jeroen P W J Maljaars, C Janneke van der Woude, Adriaan A van Bodegraven, Bas Oldenburg, Mark Löwenberg, Vincent B Nieuwenhuijs, Floris Imhann, Suzanne van Sommeren, Rudi Alberts, Ramnik J Xavier, Gerard Dijkstra, Klaas Nico Faber, C Marcelo Aldaz, Rinse K Weersma and Eleonora A M Festen.

in Journal of Crohn's and Colitis

April 2018; p ublished online January 2018 .

Journal Article. Subjects: Pathology; Physiology; Research Methods in Life Sciences; Clinical Genetics; Epidemiology. 4512 words.

Abstract

Background and Aims

Crohn’s disease [CD] is a chronic inflammatory disease with unpredictable behaviour....

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Hepatic Sulfotransferase as a Nephropreventing Target by Suppression of the Uremic Toxin Indoxyl Sulfate Accumulation in Ischemic Acute Kidney Injury

Hideyuki Saito, Misato Yoshimura, Chika Saigo, Megumi Komori, Yui Nomura, Yuko Yamamoto, Masataka Sagata, Ayaka Wakida, Erina Chuman, Kazuhiko Nishi and Hirofumi Jono.

in Toxicological Sciences

September 2014; p ublished online September 2014 .

Journal Article. Subjects: Medical Toxicology; Research Methods in Life Sciences; Pathology. 7886 words.

Ischemia/reperfusion (I/R)-induced acute kidney injury (AKI) is evoked by diverse pathophysiological conditions and/or surgical procedures. Here, we evaluated the nephropreventive effect of...

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Oral Delivery of Nanoparticles Loaded With Ginger Active Compound, 6-Shogaol, Attenuates Ulcerative Colitis and Promotes Wound Healing in a Murine Model of Ulcerative Colitis

Mingzhen Zhang, Changlong Xu, Dandan Liu, Moon Kwon Han, Lixin Wang and Didier Merlin.

in Journal of Crohn's and Colitis

January 2018; p ublished online August 2017 .

Journal Article. Subjects: Pathology; Physiology; Research Methods in Life Sciences. 7784 words.

Abstract

Background and Aims

Oral drug delivery is the most attractive pathway for ulcerative colitis [UC] therapy,...

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Role of Vitamin D in the Natural History of Inflammatory Bowel Disease

Ole Haagen Nielsen, Lars Rejnmark and Alan C Moss.

in Journal of Crohn's and Colitis

May 2018; p ublished online February 2018 .

Journal Article. Subjects: Pathology; Physiology; Research Methods in Life Sciences. 8650 words.

Abstract

Inflammatory bowel disease [IBD], including ulcerative colitis and Crohn’s disease, is a chronic and unpredictable condition characterised by...

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TREM-1 Inhibition Restores Impaired Autophagy Activity and Reduces Colitis in Mice

Tunay Kökten, Sébastien Gibot, Patricia Lepage, Silvia D’Alessio, Julie Hablot, Ndeye-Coumba Ndiaye, Hélène Busby-Venner, Céline Monot, Benjamin Garnier, David Moulin, Jean-Yves Jouzeau, Franck Hansmannel, Silvio Danese, Jean-Louis Guéant, Sylviane Muller and Laurent Peyrin-Biroulet.

in Journal of Crohn's and Colitis

January 2018; p ublished online September 2017 .

Journal Article. Subjects: Pathology; Physiology; Research Methods in Life Sciences. 9428 words.

Abstract

Background and Aims

Triggering receptor expressed on myeloid cells-1 [TREM-1] is known to amplify...

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