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Preclinical Medicine x Nephrology x clear all

Aldosterone Does Not Contribute to Renal p21 Expression During the Development of Angiotensin II-Induced Hypertension in Mice

Daisuke Nakano, Bai Lei, Kento Kitada, Hirofumi Hitomi, Hiroyuki Kobori, Hirohito Mori, Kazushi Deguchi, Tsutomu Masaki, Tohru Minamino and Akira Nishiyama.

in American Journal of Hypertension

March 2012; p ublished online March 2012 .

Journal Article. Subjects: Anatomy; Nephrology. 3847 words.

Background:

We recently reported that aldosterone-induced cellular senescence via an increase in p21, a cyclin-dependent kinase (CDK) inhibitor, in rat...

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Altered Expression of Renal Aquaporins and α-Adducin Polymorphisms May Contribute to the Establishment of Salt-Sensitive Hypertension

Giuseppe Procino, Francesca Romano, Lucia Torielli, Patrizia Ferrari, Giuseppe Bianchi, Maria Svelto and Giovanna Valenti.

in American Journal of Hypertension

July 2011; p ublished online July 2011 .

Journal Article. Subjects: Anatomy; Nephrology. 4977 words.

Background

Sodium-sensitive hypertension is caused by renal tubular dysfunction, leading to increased retention of sodium and water. Previous findings have...

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Autonomic Failure

Edited by Christopher J. Mathias and Sir Roger Bannister.

May 2013; p ublished online July 2013 .

Book. Subjects: Neurology; Anatomy; Urology; Respiratory Medicine and Pulmonology; Gastroenterology; Nephrology; Pain Medicine; Cardiovascular Medicine; Ophthalmology; Reproductive Medicine; Immunology; Endocrinology and Diabetes; Paediatrics; Geriatric Medicine; Anaesthetics; Pharmacology; Medical Toxicology; Surgery. 928 pages.

This new edition of Autonomic Failure features numerous new chapters and makes diagnosis increasingly precise by fully evaluating the underlying anatomical and functional deficits, thereby...

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CCR5 deficiency does not reduce hypertensive end-organ damage in mice

Christian Krebs, Christoph Fraune, Robin Schmidt-Haupt, Jan-Eric Turner, Ulf Panzer, Michael N. Quang, Andrea Tannapfel, Joachim Velden, Rolf A. Stahl and Ulrich O. Wenzel.

in American Journal of Hypertension

April 2012; p ublished online April 2012 .

Journal Article. Subjects: Anatomy; Nephrology. 4467 words.

Background

CCR5 is expressed on infiltrating T cells in hypertensive mice and CCR5 antagonists reduce hypertension making CCR5 an interesting target in...

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Early Treatment With Olmesartan Prevents Juxtamedullary Glomerular Podocyte Injury and the Onset of Microalbuminuria in Type 2 Diabetic Rats

Tadashi Sofue, Hideyasu Kiyomoto, Hiroyuki Kobori, Maki Urushihara, Yoko Nishijima, Kumiko Kaifu, Taiga Hara, Sachiko Matsumoto, Atsuhiko Ichimura, Hiroyuki Ohsaki, Hirofumi Hitomi, Hiroshi Kawachi, Melvin R. Hayden, Adam Whaley-Connell, James R. Sowers, Sadayoshi Ito, Masakazu Kohno and Akira Nishiyama.

in American Journal of Hypertension

May 2012; p ublished online May 2012 .

Journal Article. Subjects: Anatomy; Nephrology. 4975 words.

Background

Studies were performed to determine if early treatment with an angiotensin II (Ang II) receptor blocker (ARB), olmesartan, prevents the onset of...

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Evidence That Prenatal Programming of Hypertension by Dietary Protein Deprivation Is Mediated by Fetal Glucocorticoid Exposure

Sabeen Habib, Jyothsna Gattineni, Katherine Twombley and Michel Baum.

in American Journal of Hypertension

January 2011; p ublished online January 2011 .

Journal Article. Subjects: Anatomy; Nephrology. 4484 words.

Background

Prenatal programming by maternal dietary protein deprivation and prenatal dexamethasone result in a reduction in nephron number and hypertension...

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Factors Associated With Glomerular Hyperfiltration in the Early Stage of Hypertension

Paolo Palatini, Francesca Dorigatti, Francesca Saladini, Elisabetta Benetti, Lucio Mos, Adriano Mazzer, Giuseppe Zanata, Guido Garavelli and Edoardo Casiglia.

in American Journal of Hypertension

September 2012; p ublished online September 2012 .

Journal Article. Subjects: Anatomy; Nephrology. 4511 words.

Background

Glomerular hyperfiltration predicts development of nephropathy in hypertension but the factors responsible for increased glomerular filtration...

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Flutamide increases aldosterone levels in gonadectomized male but not female wistar rats

Peter J Hofmann, Marten Michaelis, Franziska Götz, Christopher Bartel, Tina Kienitz and Marcus Quinkler.

in American Journal of Hypertension

June 2012; p ublished online June 2012 .

Journal Article. Subjects: Anatomy; Nephrology. 4722 words.

Background

Sex-specific differences in blood pressure (BP) suggest an important modulating role of testosterone in the kidney. However, little is known about...

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Impact of Nephron Number Dosing on Cardiorenal Damage and Effects of ACE Inhibition

Lars Rothermund, Marcus Lorenz, Anne Schnieber, Jan Eberson, Iris Bauhaus, Marcel Bernhard Haug, Angela Schulz, Frieder Keller, Roland Vetter and Reinhold Kreutz.

in American Journal of Hypertension

April 2011; p ublished online April 2011 .

Journal Article. Subjects: Anatomy; Nephrology. 4351 words.

Background

Low nephron number is a recently identified cause of arterial hypertension. We set out to test the effect of nephron number dosing on blood...

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Increased expression of Na,K-ATPase and a selective increase in phosphorylation at Ser-11 in the cortex of the 2-kidney, 1-clip hypertensive rat

Lauren Kava, Noreen F. Rossi, Raymond Mattingly and Douglas R. Yingst.

in American Journal of Hypertension

April 2012; p ublished online April 2012 .

Journal Article. Subjects: Anatomy; Nephrology. 3278 words.

Background

The mechanism by which blood pressure increases during renovascular hypertension is incompletely understood. We, therefore, tested the hypothesis...

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