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Preclinical Medicine x Developmental Biology x clear all

Adolescent epigenetic profiles and environmental exposures from early life through peri-adolescence

Jaclyn M. Goodrich, Dana C. Dolinoy, Brisa N. Sánchez, Zhenzhen Zhang, John D. Meeker, Adriana Mercado-Garcia, Maritsa Solano-González, Howard Hu, Martha M. Téllez-Rojo and Karen E. Peterson.

in Environmental Epigenetics

P ublished online August 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 7573 words.

Epigenetic perturbations induced by environmental exposures at susceptible lifestages contribute to disease development. Even so, the influence of early life and ongoing exposures on the...

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Ancestral vinclozolin exposure alters the epigenetic transgenerational inheritance of sperm small noncoding RNAs

Andrew Schuster, Michael K. Skinner and Wei Yan.

in Environmental Epigenetics

P ublished online March 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 6687 words.

Exposure to the agricultural fungicide vinclozolin during gestation promotes a higher incidence of various diseases in the subsequent unexposed F3 and F4 generations. This phenomenon is...

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Bisphenol-A and metabolic diseases: epigenetic, developmental and transgenerational basis

Paloma Alonso-Magdalena, Francisco J. Rivera and Carlos Guerrero-Bosagna.

in Environmental Epigenetics

P ublished online October 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 6177 words.

Exposure to environmental toxicants is now accepted as a factor contributing to the increasing incidence of obesity and metabolic diseases around the world. Such environmental compounds are...

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Comparative transcriptomic analysis of human placentae at term and preterm delivery

Alison G Paquette, Heather M Brockway, Nathan D Price and Louis J Muglia.

in Biology of Reproduction

January 2018; p ublished online December 2017 .

Journal Article. Subjects: Reproduction, Growth and Development; Reproductive Medicine; Developmental Biology; Animal Reproduction. 6974 words.

Abstract

Preterm birth affects 1 out of every 10 infants in the United States, resulting in substantial neonatal morbidity and mortality. Currently, there are...

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A cross-study analysis of prenatal exposures to environmental contaminants and the epigenome: support for stress-responsive transcription factor occupancy as a mediator of gene-specific CpG methylation patterning

Elizabeth M. Martin and Rebecca C. Fry.

in Environmental Epigenetics

P ublished online January 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 5869 words.

A biological mechanism by which exposure to environmental contaminants results in gene-specific CpG methylation patterning is currently unknown. We hypothesize that gene-specific CpG...

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Developmental origins of epigenetic transgenerational inheritance

Mark A. Hanson and Michael K. Skinner.

in Environmental Epigenetics

P ublished online March 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 5996 words.

Environmental factors can induce epigenetic alterations in the germ cells that can potentially be transmitted transgenerationally. This non-genetic form of inheritance is termed epigenetic...

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Distinct reorganization of collagen architecture in lipopolysaccharide-mediated premature cervical remodeling

Shanmugasundaram Nallasamy, Meredith Akins, Breanna Tetreault, Kate Luby-Phelps and Mala Mahendroo.

in Biology of Reproduction

January 2018; p ublished online November 2017 .

Journal Article. Subjects: Reproduction, Growth and Development; Reproductive Medicine; Developmental Biology; Animal Reproduction. 7591 words.

Abstract

Previous work has identified divergent mechanisms by which cervical remodeling is achieved in preterm birth (PTB) induced by hormone withdrawal...

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DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders?

Kimberly P. Keil and Pamela J. Lein.

in Environmental Epigenetics

P ublished online January 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 11847 words.

There is now compelling evidence that gene by environment interactions are important in the etiology of autism spectrum disorders (ASDs). However, the mechanisms by which environmental...

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Early experiences can alter the size of cortical fields in prairie voles (<i>Microtus ochrogaster</i>)

A.M.H. Seelke, S.-M. Yuan, A.M. Perkeybile, L.A. Krubitzer and K.L. Bales.

in Environmental Epigenetics

P ublished online October 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 6609 words.

The neocortex of the prairie vole is composed of three well-defined sensory areas and one motor area: primary somatosensory, visual, auditory areas, and the primary motor area,...

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Early histone H4 acetylation during chromatin remodeling in equine spermatogenesis

Chelsea C Ketchum, Casey D Larsen, Alexis McNeil, Mirella L Meyer-Ficca and Ralph G Meyer.

in Biology of Reproduction

January 2018; p ublished online November 2017 .

Journal Article. Subjects: Reproduction, Growth and Development; Reproductive Medicine; Developmental Biology; Animal Reproduction. 7334 words.

Abstract

Chromatin remodeling during spermatogenesis culminates in the exchange of nucleosomes for transition proteins and protamines as an important part of...

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