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Adolescent epigenetic profiles and environmental exposures from early life through peri-adolescence

Jaclyn M. Goodrich, Dana C. Dolinoy, Brisa N. Sánchez, Zhenzhen Zhang, John D. Meeker, Adriana Mercado-Garcia, Maritsa Solano-González, Howard Hu, Martha M. Téllez-Rojo and Karen E. Peterson.

in Environmental Epigenetics

P ublished online August 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 7573 words.

Epigenetic perturbations induced by environmental exposures at susceptible lifestages contribute to disease development. Even so, the influence of early life and ongoing exposures on the...

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Alterations in sperm DNA methylation, non-coding RNA expression, and histone retention mediate vinclozolin-induced epigenetic transgenerational inheritance of disease

Millissia Ben Maamar, Ingrid Sadler-Riggleman, Daniel Beck, Margaux McBirney, Eric Nilsson, Rachel Klukovich, Yeming Xie, Chong Tang, Wei Yan and Michael K Skinner.

Edited by Christopher Faulk.

in Environmental Epigenetics

P ublished online April 2018 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 10498 words.

Abstract

Epigenetic transgenerational inheritance of disease and phenotypic variation can be induced by several toxicants, such as vinclozolin. This phenomenon...

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Ancestral vinclozolin exposure alters the epigenetic transgenerational inheritance of sperm small noncoding RNAs

Andrew Schuster, Michael K. Skinner and Wei Yan.

in Environmental Epigenetics

P ublished online March 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 6687 words.

Exposure to the agricultural fungicide vinclozolin during gestation promotes a higher incidence of various diseases in the subsequent unexposed F3 and F4 generations. This phenomenon is...

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Bisphenol-A and metabolic diseases: epigenetic, developmental and transgenerational basis

Paloma Alonso-Magdalena, Francisco J. Rivera and Carlos Guerrero-Bosagna.

in Environmental Epigenetics

P ublished online October 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 6177 words.

Exposure to environmental toxicants is now accepted as a factor contributing to the increasing incidence of obesity and metabolic diseases around the world. Such environmental compounds are...

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Bugs in the program: can pregnancy drugs and smoking disturb molecular reprogramming of the fetal germline, increasing heritable risk for autism and neurodevelopmental disorders?

Jill Escher.

in Environmental Epigenetics

P ublished online April 2018 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 4239 words.

Abstract

In a seeming paradox, the prevalence of autism spectrum disorder (ASD) has surged, while at the same time research has pointed to the strong...

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A cross-study analysis of prenatal exposures to environmental contaminants and the epigenome: support for stress-responsive transcription factor occupancy as a mediator of gene-specific CpG methylation patterning

Elizabeth M. Martin and Rebecca C. Fry.

in Environmental Epigenetics

P ublished online January 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 5869 words.

A biological mechanism by which exposure to environmental contaminants results in gene-specific CpG methylation patterning is currently unknown. We hypothesize that gene-specific CpG...

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Developmental origins of epigenetic transgenerational inheritance

Mark A. Hanson and Michael K. Skinner.

in Environmental Epigenetics

P ublished online March 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 5996 words.

Environmental factors can induce epigenetic alterations in the germ cells that can potentially be transmitted transgenerationally. This non-genetic form of inheritance is termed epigenetic...

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DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders?

Kimberly P. Keil and Pamela J. Lein.

in Environmental Epigenetics

P ublished online January 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 11847 words.

There is now compelling evidence that gene by environment interactions are important in the etiology of autism spectrum disorders (ASDs). However, the mechanisms by which environmental...

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Does cross-generational epigenetic inheritance contribute to cultural continuity?

Marcus E Pembrey.

in Environmental Epigenetics

P ublished online April 2018 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 6954 words.

Abstract

Human studies of cross-generational epigenetic inheritance have to consider confounding by social patterning down the generations, often referred to...

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Early experiences can alter the size of cortical fields in prairie voles (<i>Microtus ochrogaster</i>)

A.M.H. Seelke, S.-M. Yuan, A.M. Perkeybile, L.A. Krubitzer and K.L. Bales.

in Environmental Epigenetics

P ublished online October 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 6609 words.

The neocortex of the prairie vole is composed of three well-defined sensory areas and one motor area: primary somatosensory, visual, auditory areas, and the primary motor area,...

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