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Preclinical Medicine x Genetics and Genomics x clear all

3.9 Å structure of the nucleosome core particle determined by phase-plate cryo-EM

Eugene Y.D. Chua, Vinod K. Vogirala, Oviya Inian, Andrew S.W. Wong, Lars Nordenskiöld, Juergen M. Plitzko, Radostin Danev and Sara Sandin.

in Nucleic Acids Research

September 2016; p ublished online August 2016 .

Journal Article. Subjects: Molecular and Cell Biology; Genetics and Genomics; Research Methods in Life Sciences; Proteins; Molecular Biology and Genetics. 3716 words.

The Volta phase plate is a recently developed electron cryo-microscopy (cryo-EM) device that enables contrast enhancement of biological samples. Here we have evaluated the potential of...

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The <i>ACE</i> I/D Polymorphism in US Adults: Limited Evidence of Association With Hypertension-Related Traits and Sex-Specific Effects by Race/Ethnicity

Renée M. Ned, Ajay Yesupriya, Giuseppina Imperatore, Diane T. Smelser, Ramal Moonesinghe, Man-Huei Chang and Nicole F. Dowling.

in American Journal of Hypertension

February 2012; p ublished online February 2012 .

Journal Article. Subjects: Genetics and Genomics; Molecular Biology and Genetics. 4427 words.

Background:

The insertion/deletion (I/D) variant (rs4646994) of the angiotensin I-converting enzyme (ACE) gene is one of the most studied polymorphisms in...

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Adolescent epigenetic profiles and environmental exposures from early life through peri-adolescence

Jaclyn M. Goodrich, Dana C. Dolinoy, Brisa N. Sánchez, Zhenzhen Zhang, John D. Meeker, Adriana Mercado-Garcia, Maritsa Solano-González, Howard Hu, Martha M. Téllez-Rojo and Karen E. Peterson.

in Environmental Epigenetics

P ublished online August 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 7573 words.

Epigenetic perturbations induced by environmental exposures at susceptible lifestages contribute to disease development. Even so, the influence of early life and ongoing exposures on the...

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Age-Dependent Association of the Polymorphisms in the Mitochondria-Shaping Gene, <i>OPA1</i>, With Blood Pressure and Hypertension in Korean Population

Hyun-Seok Jin, Siim Sõber, Kyung-Won Hong, Elin Org, Bo-Young Kim, Maris Laan, Bermseok Oh and Seon-Yong Jeong.

in American Journal of Hypertension

October 2011; p ublished online October 2011 .

Journal Article. Subjects: Genetics and Genomics; Molecular Biology and Genetics. 5082 words.

Background

Essential hypertension is associated with mitochondrial dysfunction. Because mitochondrial dynamics; mitochondrial morphological changes are...

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All-in-one construct for genome engineering using Cre-lox technology

Ana M. Mariscal, Luis González-González, Enrique Querol and Jaume Piñol.

in DNA Research

June 2016; p ublished online April 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Genetics and Genomics. 5974 words.

Mycoplasma genitalium is an appealing model of a minimal cell and synthetic biology study, and it was one of the first organisms whose genome was fully sequenced and chemically...

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Alternative splicing in tomato pollen in response to heat stress

Mario Keller, Yangjie Hu, Anida Mesihovic, Sotirios Fragkostefanakis, Enrico Schleiff and Stefan Simm.

in DNA Research

April 2017; p ublished online December 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Genetics and Genomics. 10351 words.

Abstract

Alternative splicing (AS) is a key control mechanism influencing signal response cascades in different developmental stages and under stress...

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AnABlast: a new <i>in silico</i> strategy for the genome-wide search of novel genes and fossil regions

Juan Jimenez, Caia D. S. Duncan, María Gallardo, Juan Mata and Antonio J. Perez-Pulido.

in DNA Research

December 2015; p ublished online October 2015 .

Journal Article. Subjects: Molecular Biology and Genetics; Genetics and Genomics. 5682 words.

Genome annotation, assisted by computer programs, is one of the great advances in modern biology. Nevertheless, the in silico identification of small and complex coding sequences is still...

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Analytical workflow of double-digest restriction site-associated DNA sequencing based on empirical and <i>in silico</i> optimization in tomato

Kenta Shirasawa, Hideki Hirakawa and Sachiko Isobe.

in DNA Research

April 2016; p ublished online February 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Genetics and Genomics. 5699 words.

Double-digest restriction site-associated DNA sequencing (ddRAD-Seq) enables high-throughput genome-wide genotyping with next-generation sequencing technology. Consequently, this method has...

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Ancestral vinclozolin exposure alters the epigenetic transgenerational inheritance of sperm small noncoding RNAs

Andrew Schuster, Michael K. Skinner and Wei Yan.

in Environmental Epigenetics

P ublished online March 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Biological Sciences; Developmental Biology; Evolutionary Biology; Genetics and Genomics. 6687 words.

Exposure to the agricultural fungicide vinclozolin during gestation promotes a higher incidence of various diseases in the subsequent unexposed F3 and F4 generations. This phenomenon is...

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Assembly of the draft genome of buckwheat and its applications in identifying agronomically useful genes

Yasuo Yasui, Hideki Hirakawa, Mariko Ueno, Katsuhiro Matsui, Tomoyuki Katsube-Tanaka, Soo Jung Yang, Jotaro Aii, Shingo Sato and Masashi Mori.

in DNA Research

June 2016; p ublished online April 2016 .

Journal Article. Subjects: Molecular Biology and Genetics; Genetics and Genomics. 8303 words.

Buckwheat (Fagopyrum esculentum Moench; 2n = 2x = 16) is a nutritionally dense annual crop widely grown in temperate zones. To accelerate molecular breeding programmes of this important...

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