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Psychiatry x Medical Oncology x clear all

Burden of addiction

Professor David J. Nutt and Dr Liam J. Nestor.

in Addiction

October 2013; p ublished online October 2013 .

Chapter. Subjects: Medical Oncology; Addiction Medicine. 2112 words.

Tobacco use is still the leading cause of preventable death in the world • Alcohol use is associated with massive and growing global disability in young males • Drug-related deaths are...

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Conclusion and overview

Professor David J. Nutt and Dr Liam J. Nestor.

in Addiction

October 2013; p ublished online October 2013 .

Chapter. Subjects: Medical Oncology; Addiction Medicine. 588 words.

• Substances of addiction are highly reinforcing because they induce pleasure. • Cocaine and amphetamines trigger exaggerated increases in dopamine. • GABA is the major inhibitory neurotransmitter...

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The dopamine system and addiction

Professor David J. Nutt and Dr Liam J. Nestor.

in Addiction

October 2013; p ublished online October 2013 .

Chapter. Subjects: Medical Oncology; Addiction Medicine. 2927 words.

• Dopamine release is involved in the reinforcing effects of addictive substances • Dopamine release can be blunted by substance abuse • Dopamine release is involved in drug craving •...

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Drug pharmacokinetics and abuse liability

Professor David J. Nutt and Dr Liam J. Nestor.

in Addiction

October 2013; p ublished online October 2013 .

Chapter. Subjects: Medical Oncology; Addiction Medicine. 1897 words.

• Pharmacokinetics refers to the effect of the body on drugs • Pharmacokinetics predict the abuse liability of drugs • Route of administration (e.g., iv) predicts the speed at which drugs...

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The GABA system and addiction

Professor David J. Nutt and Dr Liam J. Nestor.

in Addiction

October 2013; p ublished online October 2013 .

Chapter. Subjects: Medical Oncology; Addiction Medicine. 3119 words.

• GABA is the major inhibitory neurotransmitter in the brain • GABA binds with GABAA and GABAB receptors to inhibit neuronal activity • Substances of abuse can down regulate or up regulate...

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The glutamate system and addiction

Professor David J. Nutt and Dr Liam J. Nestor.

in Addiction

October 2013; p ublished online October 2013 .

Chapter. Subjects: Medical Oncology; Addiction Medicine. 2864 words.

• Addiction involves enduring neuroplasticity in the reward circuitry of the brain • Neuroplasticity is a result of glutamate-dependent long-term potentiation • Glutamate is an excitatory...

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Key elements of addiction

Professor David J. Nutt and Dr Liam J. Nestor.

in Addiction

October 2013; p ublished online October 2013 .

Chapter. Subjects: Medical Oncology; Addiction Medicine. 1828 words.

• Addictive substances are highly reinforcing • They are reinforcing because they induce pleasure • Pleasure leads to “liking” the effects of addictive substances • “Liking” a substance...

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Neurobiological processes in addiction

Professor David J. Nutt and Dr Liam J. Nestor.

in Addiction

October 2013; p ublished online October 2013 .

Chapter. Subjects: Medical Oncology; Addiction Medicine. 2722 words.

• The brain controls necessary motivational and cognitive processes • These processes involve a network of independent and overlapping brain circuits • These processes involve reward,...

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ODR Geriatric Medicine

Edited by Margot Gosney, Adam Harper and Simon Conroy.

July 2012; p ublished online October 2012 .

Book. Subjects: Geriatric Medicine; Acute Medicine; Cardiovascular Medicine; Respiratory Medicine and Pulmonology; Gastroenterology; Endocrinology and Diabetes; Nephrology; Rheumatology; Infectious Diseases; Psychiatry; Neurology; Genito-urinary Medicine; Rehabilitation Medicine; Palliative Medicine; Dermatology; Medical Oncology. 624 pages.

This resource provides an evidence-based guide for both trainees and consultants in geriatric medicine and those interested in geriatric medicine. Designed in line with the core Royal...

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The opioid system and addiction

Professor David J. Nutt and Dr Liam J. Nestor.

in Addiction

October 2013; p ublished online October 2013 .

Chapter. Subjects: Medical Oncology; Addiction Medicine. 2462 words.

• The brain contains a complex system of endogenous opioid peptides • These peptides are called endorphins, encephalins and dynorphin • Endorphins preferentially bind to the mu opioid...

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