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Adaptive T-cell immunity and tumor antigen recognition

Pedro Romero and Pierre G Coulie.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Clinical Oncology. 5684 words.

Current advances in cancer immunotherapy are based on the antigenicity of human tumors, and also on their immunogenicity. Their antigenicity results from the presence at the cell surface of...

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Adoptive lymphocyte (stem cell) therapy in cancer

Sophie Derniame and Aurore Saudemont.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Clinical Oncology. 6065 words.

Haematopoietic stem cell transplantation (HSCT) is the infusion of haematopoietic stem cells and progenitor cells to restore a patient’s haematopoiesis. With more than 40 years of research...

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Adoptive T-cell therapy using TILs for the treatment of metastatic melanoma

Marco Donia, Eva Ellebæk and Inge Marie Svane.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Clinical Oncology. 6836 words.

Adoptive T-cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs or TIL-based ACT) is a personalized treatment for cancer defined as the infusion of T cells isolated from the...

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Antibody therapies: defining appropriate cell surface epitopes for targeting tumors

Gabriele Multhoff and Michael Stanglmaier.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Clinical Oncology. 6280 words.

Numerous tumor mouse models have clearly shown that an active immune system can monitor, edit and destroy malignantly transformed cells. However, the capacity of the immune system to fight...

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Cancer stem cells (CSCs) and epithelial-to-mesenchymal transition (EMT): Tumor cell plasticity challenges immunotherapy

Tarik Regad and Morgan G Mathieu.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Clinical Oncology. 5887 words.

Cancer stem cells (CSCs) or cancer-initiating cells are populations of cancer cells that possess the stem cell properties of self-renewal and differentiation and therefore behave as their...

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Chimeric antigen receptor gene therapy in cancer

John S Bridgeman and David E Gilham.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Clinical Oncology. 6056 words.

T cells are a major effector arm of the adaptive immune system and possess the potential to eliminate tumors. However, this potential is blunted in the cancer-bearing patient as a result of...

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DNA vaccines

Lindy G Durrant, Wei Xue, Lee R Machado, Rachael L Metheringham and Victoria A Brentville.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Clinical Oncology. 6604 words.

A number of significant developments in DNA vaccine research have led to the resurgence of this field as a promising approach for the treatment of cancer. Notably, these include improved...

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‘Hard’ and ‘soft’ loss of MHC class I expression in cancer cells

Natalia Aptsiauri, Angel M. Garcia-Lora and Federico Garrido.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Clinical Oncology. 7043 words.

Altered MHC class I expression is a hallmark of malignant transformation and tumor immune escape. Using immunohistochemistry and molecular techniques it has been demonstrated that many...

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HER2/neu as a target for vaccine and antibody-directed therapies

Constantin N Baxevanis and Sonia A Perez.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Clinical Oncology. 7488 words.

A novel modality toward the treatment of HER2/neu-positive malignancies, mostly including breast and, more recently, prostate carcinomas, has been the use of vaccines targeting HER2/neu...

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Identification of tumor antigens for clinical evaluation

Jayakumar Vadakekolathu, Amanda K Miles, David J Boocock and Stephanie EB McArdle.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Clinical Oncology. 5511 words.

The idea of the immune system being able to fight cancerous cells was first put forward during the 18th century when German doctors observed that infected tumors would often shrink...

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