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Ablation of Grb10 Specifically in Muscle Impacts Muscle Size and Glucose Metabolism in Mice

Lowenna J Holt, Amanda E Brandon, Lewin Small, Eurwin Suryana, Elaine Preston, Donna Wilks, Nancy Mokbel, Chantal A Coles, Jason D White, Nigel Turner, Roger J Daly and Gregory J Cooney.

in Endocrinology

P ublished online January 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 6668 words.

Abstract

Grb10 is an adaptor-type signaling protein most highly expressed in tissues involved in insulin action and glucose metabolism, such as muscle,...

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ACC2 Deletion Enhances IMCL Reduction Along With Acetyl-CoA Metabolism and Improves Insulin Sensitivity in Male Mice

Hiroyuki Takagi, Tatsuya Ikehara, Yuto Kashiwagi, Kumi Hashimoto, Isamu Nanchi, Atsuyuki Shimazaki, Hirohide Nambu and Hideo Yukioka.

in Endocrinology

P ublished online June 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 8054 words.

Abstract

Intramyocellular lipid (IMCL) accumulation in skeletal muscle greatly contributes to lipid-induced insulin resistance. Because acetyl-coenzyme A (CoA)...

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Acetylcholine Modulates the Hormones of the Growth Hormone/Insulinlike Growth Factor-1 Axis During Development in Mice

Marie-José Lecomte, Chloé Bertolus, Nélina Ramanantsoa, Françoise Saurini, Jacques Callebert, Catherine Sénamaud-Beaufort, Maud Ringot, Thomas Bourgeois, Boris Matrot, Corinne Collet, Jeannette Nardelli, Jacques Mallet, Guilan Vodjdani, Jorge Gallego, Jean-Marie Launay and Sylvie Berrard.

in Endocrinology

P ublished online March 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 10764 words.

Abstract

Pituitary growth hormone (GH) and insulinlike growth factor (IGF)-1 are anabolic hormones whose physiological roles are particularly important during...

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ACTIVExtend: 24 Months of Alendronate After 18 Months of Abaloparatide or Placebo for Postmenopausal Osteoporosis

Henry G Bone, Felicia Cosman, Paul D Miller, Gregory C Williams, Gary Hattersley, Ming-yi Hu, Lorraine A Fitzpatrick, Bruce Mitlak, Socrates Papapoulos, René Rizzoli, Robin K Dore, John P Bilezikian and Kenneth G Saag.

in The Journal of Clinical Endocrinology & Metabolism

P ublished online May 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 5356 words.

Abstract

Purpose

In women with postmenopausal osteoporosis, we investigated the effects of 24 months of treatment...

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The AKT/BCL-2 Axis Mediates Survival of Uterine Leiomyoma in a Novel 3D Spheroid Model

Vania Vidimar, Debabrata Chakravarti, Serdar E Bulun, Ping Yin, Romana Nowak, Jian-Jun Wei and J Julie Kim.

in Endocrinology

P ublished online January 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 5858 words.

Abstract

A deeper understanding of the pathways that drive uterine leiomyoma (ULM) growth and survival requires model systems that more closely mimic the in...

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Alemtuzumab-Induced Thyroid Dysfunction Exhibits Distinctive Clinical and Immunological Features

Nadia Pariani, Mark Willis, Ilaria Muller, Sarah Healy, Taha Nasser, Anne McGowan, Greta Lyons, Joanne Jones, Krishna Chatterjee, Colin Dayan, Neil Robertson, Alasdair Coles and Carla Moran.

in The Journal of Clinical Endocrinology & Metabolism

P ublished online June 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 5132 words.

Abstract

Context

Alemtuzumab, a highly effective treatment for multiple sclerosis (MS), predisposes to Graves...

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Altered Asparagine and Glutamate Homeostasis Precede Coronary Artery Disease and Type 2 Diabetes

Filip Ottosson, Einar Smith, Olle Melander and Céline Fernandez.

in The Journal of Clinical Endocrinology & Metabolism

P ublished online May 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 5215 words.

Abstract

Context

Type 2 diabetes mellitus (T2DM) is accompanied by an increased risk for coronary artery disease...

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Altered Expression of miR-181a-5p and miR-23a-3p Is Associated With Obesity and TNF<i>α</i>-Induced Insulin Resistance

Javier Lozano-Bartolomé, Gemma Llauradó, Manel Portero-Otin, Antonio Altuna-Coy, Gemma Rojo-Martínez, Joan Vendrell, Rosa Jorba, Esther Rodríguez-Gallego and Matilde R Chacón.

in The Journal of Clinical Endocrinology & Metabolism

P ublished online February 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 6082 words.

Abstract

Context

The proinflammatory cytokine TNFα is a key player in insulin resistance (IR). The role of miRNAs...

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Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS

Genevieve E Ryan, Shaddy Malik and Pamela L Mellon.

in Endocrinology

P ublished online February 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 9016 words.

Abstract

Polycystic ovary syndrome (PCOS), the most common endocrinopathy in women of reproductive age, is characterized by hyperandrogenism, anovulation, and...

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AR Signaling in Prostate Cancer Regulates a Feed-Forward Mechanism of Androgen Synthesis by Way of <i>HSD3B1</i> Upregulation

Daniel Hettel, Ao Zhang, Mohammad Alyamani, Michael Berk and Nima Sharifi.

in Endocrinology

P ublished online May 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 3994 words.

Abstract

3βHSD1 enzymatic activity is essential for synthesis of potent androgens from adrenal precursor steroids in prostate cancer. A germline variant in HSD...

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