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Science and Mathematics x Clinical Pharmacology and Therapeutics x Surgery x clear all

Cardioplegic arrest induces apoptosis signal-pathway in myocardial endothelial cells and cardiac myocytes

Uwe M. Fischer, Oliver Klass, Ulrike Stock, Jerry Easo, Hans J. Geissler, Juergen H. Fischer, Wilhelm Bloch and Uwe Mehlhorn.

in European Journal of Cardio-Thoracic Surgery

June 2003; p ublished online June 2003 .

Journal Article. Subjects: Cardiothoracic Surgery; Clinical Pharmacology and Therapeutics; Cardiovascular Medicine; Molecular and Cell Biology; Molecular Biology and Genetics. 3332 words.

Objective: Myocardial ischemia–reperfusion is associated with free radical-mediated injury and may be involved in cardiac apoptosis. The purpose of our study was to investigate...

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Donor heart contractile dysfunction following prolonged ex vivo preservation can be prevented by gene-mediated β-adrenergic signaling modulation

Hendrik T. Tevaearai, G. Brant Walton, Andrea D. Eckhart, Janelle R. Keys and Walter J. Koch.

in European Journal of Cardio-Thoracic Surgery

November 2002; p ublished online November 2002 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Cardiovascular Medicine; Molecular and Cell Biology; Transplant Surgery; Molecular Biology and Genetics. 2991 words.

Objectives: Reperfusion after myocardial ischemia goes together with alteration of the β-adrenergic (βAR) signaling. Especially the level and catalytic activity of β AR kinase...

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The effects of preoperative statins on the incidence of postoperative acute kidney injury in patients undergoing cardiac surgeries

Mohammad Hassan Nemati and Behrooz Astaneh.

in Interactive CardioVascular and Thoracic Surgery

October 2015; p ublished online July 2015 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Professional Development in Medicine; Molecular and Cell Biology; Cardiovascular Medicine; Cardiothoracic Surgery; Molecular Biology and Genetics. 3742 words.

OBJECTIVES

Recent evidence has emphasized multifunctional therapeutic effects of statins on renal protection after cardiac surgeries. We aimed to assess the...

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Effects of purified poloxamer 407 gel on vascular occlusion and the coronary endothelium

Munir Boodhwani, Jun Feng, Shigetoshi Mieno, Basel Ramlawi, Neel Sodha, Richard Clements and Frank W. Sellke.

in European Journal of Cardio-Thoracic Surgery

May 2006; p ublished online May 2006 .

Journal Article. Subjects: Cardiothoracic Surgery; Molecular and Cell Biology; Cardiovascular Medicine; Surgery; Clinical Pharmacology and Therapeutics; Molecular Biology and Genetics. 3889 words.

Objective: Vascular occlusion during off-pump coronary surgery often results in sub-optimal visualization and endothelial damage of the target vessel. We have previously...

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Enhancement of Na<sup>+</sup>,K<sup>+</sup>-ATPase and Ca<sup>2+</sup>-ATPase activities in multi-cycle ischemic preconditioning in rabbit hearts

Toshihiro Yorozuya, Naoto Adachi, Kentaro Dote, Kazuo Nakanishi, Yasushi Takasaki and Tatsuru Arai.

in European Journal of Cardio-Thoracic Surgery

November 2004; p ublished online November 2004 .

Journal Article. Subjects: Cardiothoracic Surgery; Molecular and Cell Biology; Cardiovascular Medicine; Clinical Pharmacology and Therapeutics; History of Medicine; Molecular Biology and Genetics. 3517 words.

Objective: Ischemic preconditioning (IP) has been shown to attenuate intracellular Na+ accumulation and Ca2+ overload during ischemia and reperfusion, both of which are closely...

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Fusion of bone marrow-derived stem cells with cardiomyocytes in a heterologous in vitro model

Jens Garbade, Andreas Schubert, Ardawan Julian Rastan, Dominik Lenz, Thomas Walther, Jan Fritz Gummert, Stefan Dhein and Friedrich-Wilhelm Mohr.

in European Journal of Cardio-Thoracic Surgery

November 2005; p ublished online November 2005 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Cardiovascular Medicine; Molecular and Cell Biology; Transplant Surgery; Molecular Biology and Genetics. 5250 words.

Objective: Recent studies have demonstrated that transplanted bone marrow-derived stem cells (BMCs) possess a broad differentiation potential and are able to form new...

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Heat shock protein, inducible nitric oxide synthase and apoptotic markers in the acute phase of human cardiac transplantation

Serban C. Stoica, Duwarakan K. Satchithananda, Carl Atkinson, Susan Charman, Martin Goddard and Stephen R. Large.

in European Journal of Cardio-Thoracic Surgery

December 2003; p ublished online December 2003 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Cardiovascular Medicine; Molecular and Cell Biology; Transplant Surgery; Molecular Biology and Genetics. 3916 words.

Objective: Solid organ transplantation is associated with activation of apoptotic pathways and other stress markers. We aimed to describe the expression of Bax, Bcl-2, iNOs and...

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Mitochondrial DNA deletions in coronary artery bypass grafting patients

Sidney Levitsky, Jari Laurikka, Robert D. Stewart, Christian T. Campos, Steven J. Lahey and James D. McCully.

in European Journal of Cardio-Thoracic Surgery

November 2003; p ublished online November 2003 .

Journal Article. Subjects: Anatomy; Cardiothoracic Surgery; Molecular and Cell Biology; Cardiovascular Medicine; Clinical Pharmacology and Therapeutics; History of Medicine; Molecular Biology and Genetics. 4093 words.

Objective: Mitochondrial DNA (mitoDNA) deletions have been shown to increase with aging and ischemia and have been suggested to contribute to myocardial dysfunction. The...

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Mitral valve repair of isolated posterior leaflet prolapse: resect or respect?

Christos Tourmousoglou, Spiros Lalos and Dimitrios Dougenis.

in Interactive CardioVascular and Thoracic Surgery

December 2014; p ublished online September 2014 .

Journal Article. Subjects: Cardiothoracic Anaesthesia; Cardiothoracic Surgery; Professional Development in Medicine; Molecular and Cell Biology; Surgical Oncology; Cardiovascular Medicine; Gastroenterology; Clinical Pharmacology and Therapeutics; Molecular Biology and Genetics. 4479 words.

A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether it is best in a patient with posterior leaflet prolapse to resect...

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Restoration of sarcoplasmic reticulum protein level by thyroid hormone contributes to partial improvement of myocardial function, but not to glucose metabolism in an early failing heart

Masahito Minakawa, Koh Takeuchi, Kazuo Ito, Takao Tsushima, Kozo Fukui, Shunichi Takaya and Ikuo Fukuda.

in European Journal of Cardio-Thoracic Surgery

October 2003; p ublished online October 2003 .

Journal Article. Subjects: Cardiothoracic Surgery; Molecular and Cell Biology; Cardiovascular Medicine; Surgery; Clinical Pharmacology and Therapeutics; Molecular Biology and Genetics. 5091 words.

Objective: In heart failure, sarcoplasmic reticulum Ca2+-ATPase (SERCA2) activity is decreased, resulting in abnormal Ca2+ handling and contractile dysfunction. We have...

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