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3.9 Å structure of the nucleosome core particle determined by phase-plate cryo-EM

Eugene Y.D. Chua, Vinod K. Vogirala, Oviya Inian, Andrew S.W. Wong, Lars Nordenskiöld, Juergen M. Plitzko, Radostin Danev and Sara Sandin.

in Nucleic Acids Research

September 2016; p ublished online August 2016 .

Journal Article. Subjects: Molecular and Cell Biology; Genetics and Genomics; Research Methods in Life Sciences; Proteins; Molecular Biology and Genetics. 3716 words.

The Volta phase plate is a recently developed electron cryo-microscopy (cryo-EM) device that enables contrast enhancement of biological samples. Here we have evaluated the potential of...

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Automated physics-based design of synthetic riboswitches from diverse RNA aptamers

Amin Espah Borujeni, Dennis M. Mishler, Jingzhi Wang, Walker Huso and Howard M. Salis.

in Nucleic Acids Research

January 2016; p ublished online November 2015 .

Journal Article. Subjects: Research Methods in Life Sciences; Bioinformatics and Computational Biology; Proteins; Molecular Biology and Genetics. 8537 words.

Riboswitches are shape-changing regulatory RNAs that bind chemicals and regulate gene expression, directly coupling sensing to cellular actuation. However, it remains unclear how their...

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Cardiac haemangioma with coronary–pulmonary artery fistula in one patient

Hongfei Xu, Weidong Li, Peng Teng and Yiming Ni.

in European Journal of Cardio-Thoracic Surgery

February 2015; p ublished online November 2014 .

Journal Article. Subjects: Research Methods in Life Sciences; Anatomy; Cardiovascular Medicine; Molecular and Cell Biology; Molecular Biology and Genetics. 1136 words.

Cardiac haemangioma and coronary–pulmonary artery fistula are both rare entities. We present the case of a 45-year-old symptomatic male patient with a rare cardiac cavernous haemangioma....

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Cardiac surgery-associated acute kidney injury: risk factors analysis and comparison of prediction models

Darko Kristovic, Ivica Horvatic, Ino Husedzinovic, Zeljko Sutlic, Igor Rudez, Davor Baric, Daniel Unic, Robert Blazekovic and Matija Crnogorac.

in Interactive CardioVascular and Thoracic Surgery

September 2015; p ublished online June 2015 .

Journal Article. Subjects: Research Methods in Life Sciences; Clinical Pharmacology and Therapeutics; Cardiovascular Medicine; Molecular and Cell Biology; Molecular Biology and Genetics. 5765 words.

OBJECTIVES

Cardiac surgery-associated acute kidney injury (AKI) is a well-known factor influencing patients' long-term morbidity and mortality. Several...

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Combined aortic valve replacement and coronary artery bypass grafting in octogenarians: results not as excellent as reported

Andreas Böning.

in European Journal of Cardio-Thoracic Surgery

January 2015; p ublished online April 2014 .

Journal Article. Subjects: Research Methods in Life Sciences; Cardiovascular Medicine; Molecular and Cell Biology; Molecular Biology and Genetics. 247 words.

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Comprehensive mutational scanning of a kinase <i>in vivo</i> reveals substrate-dependent fitness landscapes

Alexandre Melnikov, Peter Rogov, Li Wang, Andreas Gnirke and Tarjei S. Mikkelsen.

in Nucleic Acids Research

August 2014; p ublished online June 2014 .

Journal Article. Subjects: Research Methods in Life Sciences; Enzymology; Molecular Biology and Genetics. 4829 words.

Deep mutational scanning has emerged as a promising tool for mapping sequence–activity relationships in proteins, ribonucleic acid and deoxyribonucleic acid. In this approach, diverse...

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Detection of abnormal circumflex artery from the right coronary sinus in a patient scheduled for root aneurysm repair

Matthias Siepe, Bartosz Rylski, Fabian Alexander Kari and Friedhelm Beyersdorf.

in Interactive CardioVascular and Thoracic Surgery

November 2014; p ublished online July 2014 .

Journal Article. Subjects: Anatomy; Cardiovascular Medicine; Molecular Biology and Genetics; Molecular and Cell Biology; Research Methods in Life Sciences. 607 words.

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‘Early’ and ‘late’ timing for renal replacement therapy in acute kidney injury after cardiac surgery: a prospective, interventional, controlled, single-centre trial

Giuseppe Crescenzi, Lucia Torracca, Michele Danilo Pierri, Concetta Rosica, Christopher Munch and Filippo Capestro.

in Interactive CardioVascular and Thoracic Surgery

May 2015; p ublished online February 2015 .

Journal Article. Subjects: Cardiovascular Medicine; Surgery; Cardiothoracic Surgery; Molecular Biology and Genetics; Molecular and Cell Biology; Research Methods in Life Sciences. 4303 words.

OBJECTIVES

Acute kidney injury after cardiac surgery (CS-AKI) is strongly associated with in-hospital mortality and morbidity. We aimed to investigate...

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Engineering a high-affinity methyl-CpG-binding protein

Helle F. Jørgensen, Karen Adie, Pascal Chaubert and Adrian P. Bird.

in Nucleic Acids Research

August 2006; p ublished online August 2006 .

Journal Article. Subjects: Research Methods in Life Sciences; Proteins; Molecular Biology and Genetics. 4350 words.

Core members of the MBD protein family (MeCP2, MBD1, MBD2 and MBD4) share a methyl-CpG-binding domain that has a specific affinity for methylated CpG sites in double-stranded DNA. By...

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A fluorescence-based helicase assay: application to the screening of G-quadruplex ligands

Oscar Mendoza, Nassima Meriem Gueddouda, Jean-Baptiste Boulé, Anne Bourdoncle and Jean-Louis Mergny.

in Nucleic Acids Research

June 2015; p ublished online March 2015 .

Journal Article. Subjects: Research Methods in Life Sciences; Enzymology; Molecular Biology and Genetics; Proteins. 6241 words.

Helicases, enzymes that unwind DNA or RNA structure, are present in the cell nucleus and in the mitochondrion. Although the majority of the helicases unwind DNA or RNA duplexes, some of...

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