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A fluorescence-based helicase assay: application to the screening of G-quadruplex ligands

Oscar Mendoza, Nassima Meriem Gueddouda, Jean-Baptiste Boulé, Anne Bourdoncle and Jean-Louis Mergny.

in Nucleic Acids Research

June 2015; p ublished online March 2015 .

Journal Article. Subjects: Research Methods in Life Sciences; Enzymology; Molecular Biology and Genetics; Proteins. 6241 words.

Helicases, enzymes that unwind DNA or RNA structure, are present in the cell nucleus and in the mitochondrion. Although the majority of the helicases unwind DNA or RNA duplexes, some of...

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High-temperature single-molecule kinetic analysis of thermophilic archaeal MCM helicases

Kelly M. Schermerhorn, Nathan Tanner, Zvi Kelman and Andrew F. Gardner.

in Nucleic Acids Research

October 2016; p ublished online July 2016 .

Journal Article. Subjects: Enzymology; Molecular Biology and Genetics; Proteins. 5625 words.

The minichromosome maintenance (MCM) complex is the replicative helicase responsible for unwinding DNA during archaeal and eukaryal genome replication. To mimic long helicase events in the...

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Identification of human telomerase assembly inhibitors enabled by a novel method to produce hTERT

Guillaume Kellermann, Markus Kaiser, Florent Dingli, Olivier Lahuna, Delphine Naud-Martin, Florence Mahuteau-Betzer, Damarys Loew, Evelyne Ségal-Bendirdjian, Marie-Paule Teulade-Fichou and Sophie Bombard.

in Nucleic Acids Research

September 2015; p ublished online May 2015 .

Journal Article. Subjects: Proteins; Enzymology; Molecular and Cell Biology; Molecular Biology and Genetics. 7197 words.

Telomerase is the enzyme that maintains the length of telomeres. It is minimally constituted of two components: a core reverse transcriptase protein (hTERT) and an RNA (hTR). Despite its...

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Massively parallel determination and modeling of endonuclease substrate specificity

Summer B. Thyme, Yifan Song, T. J. Brunette, Mindy D. Szeto, Lara Kusak, Philip Bradley and David Baker.

in Nucleic Acids Research

December 2014; p ublished online November 2014 .

Journal Article. Subjects: Enzymology; Molecular Biology and Genetics; Proteins; Research Methods in Life Sciences. 8116 words.

We describe the identification and characterization of novel homing endonucleases using genome database mining to identify putative target sites, followed by high throughput activity...

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