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Science and Mathematics x Clinical Pharmacology and Therapeutics x clear all

Absolute Measurements of Macrophage Migration Inhibitory Factor and Interleukin-1-β mRNA Levels Accurately Predict Treatment Response in Depressed Patients

Annamaria Cattaneo, Clarissa Ferrari, Rudolf Uher, Luisella Bocchio-Chiavetto, Marco Andrea Riva and Carmine M. Pariante.

in International Journal of Neuropsychopharmacology

P ublished online May 2016 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 8487 words.

Background:

Increased levels of inflammation have been associated with a poorer response to antidepressants in several clinical samples, but these findings...

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Activation of Protein Kinases and Phosphatases Coupled to Glutamate Receptors Regulates the Phosphorylation State of DARPP32 at Threonine 75 After Repeated Exposure to Cocaine in the Rat Dorsal Striatum in a Ca<sup>2+</sup>-Dependent Manner

Jieun Kim, In Soo Ryu, Su Yeon Seo and Eun Sang Choe.

in International Journal of Neuropsychopharmacology

November 2015; p ublished online July 2015 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 5785 words.

Background:

Phosphorylation state of dopamine- and cAMP-regulated phosphoprotein, molecular weight 32kDa (DARPP32) is crucial to understand drug-mediated...

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Agomelatine Increases BDNF Serum Levels in Depressed Patients in Correlation with the Improvement of Depressive Symptoms

Giovanni Martinotti, Mauro Pettorruso, Domenico De Berardis, Paola Annunziata Varasano, Gabriella Lucidi Pressanti, Valeria De Remigis, Alessandro Valchera, Valerio Ricci, Marco Di Nicola, Luigi Janiri, Giovanni Biggio and Massimo Di Giannantonio.

in International Journal of Neuropsychopharmacology

P ublished online January 2016 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 3604 words.

Background:

Agomelatine modulates brain-derived neurotrophic factor expression via its interaction with melatonergic and serotonergic receptors and has...

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Agonist and Antagonist Effects of Aripiprazole on D<sub>2</sub>-Like Receptors Controlling Rat Brain Dopamine Synthesis Depend on the Dopaminergic Tone

Guo Fen Ma, Noora Raivio, Josefa Sabrià and Jordi Ortiz.

in International Journal of Neuropsychopharmacology

P ublished online January 2015 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 6522 words.

Background:

The atypical antipsychotic drug aripiprazole binds with high affinity to a number of G protein coupled receptors, including dopamine D2 receptor...

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alginic acid

Overview page. Subjects: Chemistry — Clinical Pharmacology and Therapeutics.

A hydrophilic polysaccharide (≈240 kDa) occurring in brown algae (brown seaweeds), especially the Californian giant kelp (Macrocystis pyrifera) and horsetail kelp (Laminaria digitata)....

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Antidepressant Effects of Abscisic Acid Mediated by the Downregulation of Corticotrophin-Releasing Hormone Gene Expression in Rats

Cong-Cong Qi, Zhi Zhang, Hui Fang, Ji Liu, Nan Zhou, Jin-Fang Ge, Fang-Han Chen, Cheng-Bin Xiang and Jiang-Ning Zhou.

in International Journal of Neuropsychopharmacology

P ublished online December 2014 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 6747 words.

Background:

Corticotrophin-releasing hormone (CRH) is considered to be the central driving force of the hypothalamic-pituitary-adrenal axis, which plays a...

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Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation

Ji-chun Zhang, Jin Wu, Yuko Fujita, Wei Yao, Qian Ren, Chun Yang, Su-xia Li, Yukihiko Shirayama and Kenji Hashimoto.

in International Journal of Neuropsychopharmacology

P ublished online January 2015 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 8026 words.

Background:

Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), signaling represent potential therapeutic...

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antiparkinsonian

Overview page. Subjects: Clinical Pharmacology and Therapeutics — Psychology.

(Of or relating to) any drug that alleviates parkinsonism or the pseudo-parkinsonian side-effects of neuroleptic drugs such as the phenothiazines. In particular, l-dopa or bromocriptine...

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Anxiolytic-Like Effects of Increased Ghrelin Receptor Signaling in the Amygdala

Morten Jensen, Cecilia Ratner, Olga Rudenko, Søren H. Christiansen, Louise J. Skov, Cecilie Hundahl, David P.D. Woldbye and Birgitte Holst.

in International Journal of Neuropsychopharmacology

P ublished online November 2015 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 8482 words.

Background:

Besides the well-known effects of ghrelin on adiposity and food intake regulation, the ghrelin system has been shown to regulate aspects of...

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Association Study Indicates a Protective Role of Phosphatidylinositol-4-Phosphate-5-Kinase against Tardive Dyskinesia

Olga Yu Fedorenko, Anton J. M. Loonen, Florian Lang, Valentina A. Toshchakova, Evgenia G. Boyarko, Arkadiy V. Semke, Nikolay A. Bokhan, Nikolay V. Govorin, Lyubomir I. Aftanas and Svetlana A. Ivanova.

in International Journal of Neuropsychopharmacology

April 2015; p ublished online January 2015 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 3246 words.

Background:

Tardive dyskinesia is a disorder characterized by involuntary muscle movements that occur as a complication of long-term treatment with...

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