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Science and Mathematics x Medical Oncology x clear all

c-Myc–miR-29c–REV3L signalling pathway drives the acquisition of temozolomide resistance in glioblastoma

Hui Luo, Zhengxin Chen, Shuai Wang, Rui Zhang, Wenjin Qiu, Lin Zhao, Chenghao Peng, Ran Xu, Wanghao Chen, Hong-Wei Wang, Yuanyuan Chen, Jingmin Yang, Xiaotian Zhang, Shuyu Zhang, Dan Chen, Wenting Wu, Chunsheng Zhao, Gang Cheng, Tao Jiang, Daru Lu, Yongping You, Ning Liu and Huibo Wang.

in Brain

December 2015; p ublished online October 2015 .

Journal Article. Subjects: Disorders of the Nervous System; Neuropathology; Medical Oncology. 10327 words.

See Happold and Weller (doi:10.1093/awv301) for a scientific commentary on this article.

Resistance to temozolomide poses a major clinical challenge in...

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Corticosteroids compromise survival in glioblastoma

Kenneth L. Pitter, Ilaria Tamagno, Kristina Alikhanyan, Amira Hosni-Ahmed, Siobhan S. Pattwell, Shannon Donnola, Charles Dai, Tatsuya Ozawa, Maria Chang, Timothy A. Chan, Kathryn Beal, Andrew J. Bishop, Christopher A. Barker, Terreia S. Jones, Bettina Hentschel, Thierry Gorlia, Uwe Schlegel, Roger Stupp, Michael Weller, Eric C. Holland and Dolores Hambardzumyan.

in Brain

May 2016; p ublished online March 2016 .

Journal Article. Subjects: Disorders of the Nervous System; Neuropathology; Medical Oncology. 5836 words.

Glioblastoma is the most common and most aggressive primary brain tumour. Standard of care consists of surgical resection followed by radiotherapy and concomitant and maintenance...

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DEAD-box RNA helicase DDX23 modulates glioma malignancy via elevating miR-21 biogenesis

Jinlong Yin, Gunwoo Park, Jeong Eun Lee, Eun Young Choi, Ju Young Park, Tae-Hoon Kim, Nayun Park, Xiong Jin, Ji-Eun Jung, Daye Shin, Jun Hee Hong, Hyunggee Kim, Heon Yoo, Seung-Hoon Lee, Youn-Jae Kim, Jong Bae Park and Jong Heon Kim.

in Brain

September 2015; p ublished online June 2015 .

Journal Article. Subjects: Disorders of the Nervous System; Neuropathology; Medical Oncology. 9189 words.

Upregulation of microRNA-21 (miR-21) is known to be strongly associated with the proliferation, invasion, and radio-resistance of glioma cells. However, the regulatory mechanism that...

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Nerve growth factor improves visual loss in childhood optic gliomas: a randomized, double-blind, phase II clinical trial

Benedetto Falsini, Antonio Chiaretti, Daniela Rizzo, Marco Piccardi, Antonio Ruggiero, Luigi Manni, Marzia Soligo, Anna Dickmann, Matteo Federici, Annabella Salerni, Laura Timelli, Gaspare Guglielmi, Ilaria Lazzareschi, Massimo Caldarelli, Lucia Galli-Resta, Cesare Colosimo and Riccardo Riccardi.

in Brain

February 2016; p ublished online January 2016 .

Journal Article. Subjects: Disorders of the Nervous System; Neuropathology; Medical Oncology. 6047 words.

Paediatric optic pathway gliomas are low-grade brain tumours characterized by slow progression and invalidating visual loss. Presently there is no strategy to prevent visual loss in this...

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Sun safety in construction: a UK intervention study

J. Houdmont, P. Madgwick and R. Randall.

in Occupational Medicine

January 2016; p ublished online September 2015 .

Journal Article. Subjects: Medical Oncology; Occupational Medicine; Civil Engineering, Surveying, and Building. 4370 words.

Background

Interventions to promote sun safety in the UK construction sector are warranted given the high incidence of skin cancer attributable to sun...

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