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A “Fundamental Theorem” of Biomedical Informatics

Charles P. Friedman.

in Journal of the American Medical Informatics Association

March 2009; p ublished online March 2009 .

Journal Article. Subjects: Medical Statistics and Methodology; Bioinformatics and Computational Biology; Biomathematics and Statistics. 1079 words.

Abstract

This paper proposes, in words and pictures, a “fundamental theorem” to help clarify what informatics is and what it is not. In words, the theorem...

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A 10S galectin-3–U1 snRNP complex assembles into active spliceosomes

Kevin C. Haudek, Patricia G. Voss, John L. Wang and Ronald J. Patterson.

in Nucleic Acids Research

July 2016; p ublished online April 2016 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 4810 words.

In previous studies, we reported that fractionation of HeLa cell nuclear extracts on glycerol gradients revealed an endogenous ∼10S particle that contained galectin-3 and U1 snRNP and this...

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A 16S rRNA–tRNA product containing a nucleotide phototrimer and specific for tRNA in the P/E hybrid state in the <i>Escherichia coli</i> ribosome

Wayne Huggins and Paul Wollenzien.

in Nucleic Acids Research

January 2004; p ublished online January 2004 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6644 words.

Ribosome complexes containing deacyl-[math] or biotinylvalyl-[math] and an mRNA analog have been irradiated with wavelengths specific for activation of the cmo5U nucleoside at position 34 in...

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A 1.8 kb Alternative Transcript from the Human Epidermal Growth Factor Receptor Gene Encodes a Truncated form of the Receptor

Jill L. Reiter and Nita J. Maihle.

in Nucleic Acids Research

October 1996; p ublished online October 1996 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 4492 words.

The epidermal growth factor receptor (EGFR) is encoded by the c-erbB1 proto-oncogene and plays an important role in the control of cell growth and differentiation. To study the potential...

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A 21‐amino acid peptide from the cysteine cluster II of the family D DNA polymerase from <i>Pyrococcus horikoshii</i> stimulates its nuclease activity which is Mre11‐like and prefers manganese ion as the cofactor

Yulong Shen, Xiao‐Feng Tang, Hideshi Yokoyama, Eriko Matsui and Ikuo Matsui.

in Nucleic Acids Research

January 2004; p ublished online January 2004 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 7265 words.

Family D DNA polymerase (PolD) is a new type of DNA polymerase possessing polymerization and 3′–5′ exonuclease activities. Here we report the characterization of the nuclease activity of...

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A 2,2′-bipyridine ligand for incorporation into oligodeoxynucleotides: Synthesis, stability and fluorescence properties of ruthenium—DNA complexes

Kristin Wiederholt and Larry W. McLaughlin.

in Nucleic Acids Research

January 1999; p ublished online January 1999 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 4768 words.

A non-nucleoside linker based upon the ligand 2,2′-bipyridine and ethylene glycol is prepared and placed into the backbone of a number of oligonucleo-tides. The bipyridine ligand is reacted...

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A 39 Amino Acid Fragment of the Cell Cycle Regulator p21 Is Sufficient to Bind PCNA and Partially Inhibit DNA Replication <i>in vivo</i>

Junjie Chen, Richard Peters, Partha Saha, Patrick Lee, Annie Theodoras, Michele Pagano, Gerhard Wagner and Anindya Dutta.

in Nucleic Acids Research

May 1996; p ublished online May 1996 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 4650 words.

The cell cycle regulator p21 interacts with and inhibits the DNA replication and repair factor proliferating cell nuclear antigen (PCNA). We have defined a 39 amino acid fragment of p21...

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A 3D pattern matching algorithm for DNA sequences

Joan Hérisson, Guillaume Payen and Rachid Gherbi.

in Bioinformatics

March 2007; p ublished online January 2007 .

Journal Article. Subjects: Bioinformatics and Computational Biology. 4664 words.

Motivation: Biologists usually work with textual DNA sequences (succession of A, C, G and T). This representation allows biologists to study the syntax and other linguistic...

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A 43 kDa DNA Binding Protein from the Pea Chloroplast Interacts with and Stimulates the Cognate DNA Polymerase

Weiliang Chen, Amos Gaikwad, Sunil Kumar Mukherjee, Nirupam Roy Choudhary, Dhirendra Kumar and Krishna K. Tewari.

in Nucleic Acids Research

October 1996; p ublished online October 1996 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6663 words.

A DNA binding protein with DNA polymerase ‘accessory activity’ has been identified and purified to apparent homogeneity from pea chloroplasts. This protein consists of a single subunit of...

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A 5′, 8-cyclo-2′-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase β

Meng Xu, Yanhao Lai, Zhongliang Jiang, Michael A. Terzidis, Annalisa Masi, Chryssostomos Chatgilialoglu and Yuan Liu.

in Nucleic Acids Research

December 2014; p ublished online November 2014 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 9132 words.

5′,8-cyclo-2′-deoxypurines (cdPus) are common forms of oxidized DNA lesions resulting from endogenous and environmental oxidative stress such as ionizing radiation. The lesions can only be...

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