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Characterization of Nuclear Receptor-Mediated Murine Hepatocarcinogenesis of the Herbicide Pronamide and Its Human Relevance

Matthew J. LeBaron, Reza J. Rasoulpour, B. Bhaskar Gollapudi, Radhakrishna Sura, H. Lynn Kan, Melissa R. Schisler, Lynn H. Pottenger, Sabitha Papineni and David L. Eisenbrandt.

in Toxicological Sciences

November 2014; p ublished online August 2014 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical); Genetic Disease. 15305 words.

The key events responsible for mouse liver tumors induced by a pesticide (viz., pronamide) were investigated in a series of studies employing molecular, biochemical, cellular, and apical...

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Dose- and Time-Dependent Epigenetic Changes in the Livers of Fisher 344 Rats Exposed to Furan

Aline de Conti, Tetyana Kobets, Claudia Escudero-Lourdes, Beverly Montgomery, Volodymyr Tryndyak, Frederick Alan Beland, Daniel R. Doerge and Igor Petrovych Pogribny.

in Toxicological Sciences

June 2014; p ublished online March 2014 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical); Genetic Disease. 4486 words.

The presence of furan in common cooked foods along with evidence from experimental studies that lifetime exposure to furan causes liver tumors in rats and mice has caused concern to...

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Human Hepatocytes Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogen Sodium Phenobarbital in an <i>In Vivo</i> Study Using a Chimeric Mouse with Humanized Liver

Tomoya Yamada, Yu Okuda, Masahiko Kushida, Kayo Sumida, Hayato Takeuchi, Hirohisa Nagahori, Takako Fukuda, Brian G. Lake, Samuel M. Cohen and Satoshi Kawamura.

in Toxicological Sciences

November 2014; p ublished online August 2014 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical); Genetic Disease. 12146 words.

High doses of sodium phenobarbital (NaPB), a constitutive androstane receptor (CAR) activator, have been shown to produce hepatocellular tumors in rodents by a mitogenic mode of action...

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Liver Tumor Promotion by 2,3,7,8-Tetrachlorodibenzo-<i>p</i>-dioxin Is Dependent on the Aryl Hydrocarbon Receptor and TNF/IL-1 Receptors

Gregory D. Kennedy, Manabu Nukaya, Susan M. Moran, Edward Glover, Samuel Weinberg, Silvia Balbo, Stephen S. Hecht, Henry C. Pitot, Norman R. Drinkwater and Christopher A. Bradfield.

in Toxicological Sciences

July 2014; p ublished online April 2014 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical); Genetic Disease. 5336 words.

We set out to better understand the signal transduction pathways that mediate liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxn (“dioxin”). To this end, we first employed congenic...

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Persistence of Cisplatin-Induced Mutagenicity in Hematopoietic Stem Cells: Implications for Secondary Cancer Risk Following Chemotherapy

Stephen D. Dertinger, Svetlana L. Avlasevich, Dorothea K. Torous, Jeffrey C. Bemis, Souk Phonethepswath, Carson Labash, Kristine Carlson, Jared Mereness, John Cottom, James Palis and James T. MacGregor.

in Toxicological Sciences

August 2014; p ublished online August 2014 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical); Genetic Disease. 5177 words.

Cisplatin is a cytostatic agent used in the treatment of many types of cancer, but its use is associated with increased incidences of secondary leukemia. We evaluated cisplatin's in vivo ge...

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Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors

Raphaëlle Luisier, Harri Lempiäinen, Nina Scherbichler, Albert Braeuning, Miriam Geissler, Valerie Dubost, Arne Müller, Nico Scheer, Salah-Dine Chibout, Hisanori Hara, Frank Picard, Diethilde Theil, Philippe Couttet, Antonio Vitobello, Olivier Grenet, Bettina Grasl-Kraupp, Heidrun Ellinger-Ziegelbauer, John P. Thomson, Richard R. Meehan, Clifford R. Elcombe, Colin J. Henderson, C. Roland Wolf, Michael Schwarz, Pierre Moulin, Rémi Terranova and Jonathan G. Moggs.

in Toxicological Sciences

June 2014; p ublished online April 2014 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical); Genetic Disease. 6179 words.

The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of...

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Phenobarbital-Mediated Tumor Promotion in Transgenic Mice with Humanized CAR and PXR

Albert Braeuning, Alina Gavrilov, Susan Brown, C. Roland Wolf, Colin J. Henderson and Michael Schwarz.

in Toxicological Sciences

August 2014; p ublished online August 2014 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical); Genetic Disease. 6045 words.

The nuclear receptors CAR (constitutive androstane receptor) and possibly PXR (pregnane X receptor) mediate the hepatic effects of phenobarbital (PB) and similar-acting compounds. Although...

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