Journal Article

From preeclampsia to renal disease: a role of angiogenic factors and the renin–angiotensin aldosterone system?

Anne Marijn van der Graaf, Tsjitske J. Toering, Marijke M. Faas and A. Titia Lely

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 27, issue suppl_3, pages iii51-iii57
Published in print October 2012 | ISSN: 0931-0509
Published online October 2012 | e-ISSN: 1460-2385 | DOI:
From preeclampsia to renal disease: a role of angiogenic factors and the renin–angiotensin aldosterone system?

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Complicating up to 8% of pregnancies, preeclampsia is the most common glomerular disease worldwide and remains a leading cause of infant and maternal morbidity and mortality. Although the exact pathogenesis of this syndrome of hypertension and proteinuria is still incomplete, a consistent line of evidence has identified an imbalance of proangiogenic and anti-angiogenic proteins as a key factor in the development of preeclampsia. Furthermore, more attention has been recently addressed to the renin–angiotensin aldosterone system (RAAS), to provide understanding on the hypertension of preeclampsia. The imbalance of the RAAS and the imbalance between angiogenic and anti-angiogenic factors, which may be both common to preeclampsia and chronic kidney disease (CKD), might explain why a history of preeclampsia predisposes women to develop CKD. In this review, we briefly describe the characteristics of preeclampsia with a focus on the mechanisms of angiogenesis and the RAAS and its role in the pathogenesis of preeclampsia. Our main focus will be on the intriguing association between preeclampsia and the subsequent increased risk of developing CKD and on the potential mechanisms by which the risk of CKD is elevated in women with a history of preeclampsia.

Keywords: angiogenic factors; chronic kidney disease; hypertension; microalbuminuria; preeclampsia; renal haemodynamics; renin–angiotensin–aldosterone system

Journal Article.  4508 words.  Illustrated.

Subjects: Nephrology

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