anaphase promoting complex

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An E3 ubiquitin ligase (APC, cyclosome) that marks target proteins for degradation by the 26S proteasome, and is responsible for initiating sister chromatid separation and the inactivation of cyclin-dependent kinases at anaphase. It has 13 core subunits (total 1.5 MDa) and one of two loosely associated coactivators, Cdc20 and Cdh1. The binding of cyclin A inactivates the APC during S-phase.

Subjects: Medicine and Health — Chemistry.

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