fusion gene

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1. a hybrid gene, composed of parts of two other genes, arising from deletion of a chromosomal segment between two linked genes or by unequal crossing over. Hemoglobin Lepore (q.v.) is an example of such a fused gene. See cone pigment genes (CPGs), Philadelphia chromosome. 2. a laboratory construct consisting of regulatory elements from one gene ligated to the structural elements of another. Transgenic animals (q.v.) often carry fused genes.

Subjects: Genetics and Genomics.

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