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aggrecan

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ADAM family

Overview page. Subjects: Medicine and Health.

A family (a disintegrin and metalloprotease family) of membrane-anchored peptidases that cleave proteins of the cell surface and extracellular matrix (ECM) and may release membrane-bound...

See overview in Oxford Index

keratan sulfate

Overview page. Subjects: Chemistry — Medicine and Health.

A glycosaminoglycan in which the repeating disaccharide is galactose β1–4 linked to N-acetylglucosamine that is sulphated at C-6 of either or both of the Gal or GlcNAc monosaccharides. The...

See overview in Oxford Index

lecticans

Overview page. Subjects: Medicine and Health.

A family of chondroitin sulphate proteoglycans that includes aggrecan, versican, neurocan, and brevican. They have a hyaluronan-binding and C-type lectin domains and act as crosslinkers in...

See overview in Oxford Index

spondyloepiphyseal dysplasia

Overview page. Subjects: Medicine and Health.

A range of disorders due to cartilage defects, usually causing short stature and a variable range of malformations. Spondyloepiphyseal dysplasia congenita is caused by mutation in the gene...

See overview in Oxford Index