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DEXD/H box

Overview page. Subjects: Chemistry.

An element of protein sequence that is a variant of the DEAD box in which the third residue is variable and the fourth residue can be D or H. It ...

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disRNA

Overview page. Subjects: Chemistry.

abbr. for Dicer‐substrate RNA shRNAs with 29 bp stem and 2 nt 3′ overhangs. They are thought to be more potent inducers of RNAi than shorter hairpins.

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microprocessor

Overview page. Subjects: Medicine and Health.

A protein complex both necessary and sufficient for processing long primary miRNAs (pri-miRNAs) to the intermediate 60–70-nt precursor miRNAs (pre-miRNAs). It comprises drosha and the...

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microRNA

Overview page. Subjects: Biological Sciences.

A small RNA molecule that is encoded by a cell and can ‘silence’ the expression of a particular target gene within the cell (see RNA interference). miRNAs bind to target messenger RNA...

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pre-miRNA

Overview page. Subjects: Chemistry.

The product of Drosha activity on pri‐miRNA and a substrate for Dicer.

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rasiRNA

Overview page. Subjects: Chemistry.

abbr. for repeat‐associated siRNA. Transcription from opposing promoters found in repetitive DNA elements leads to the formation of long dsRNAs. These are cleaved by Dicer into...

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RISCs

Overview page. Subjects: Medicine and Health.

Multiprotein complexes (RNA-induced silencing complexes) associated with RNA interference. The protein components, which include argonaute family members, dicer, nucleases, and other...

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RNA interference

Overview page. Subjects: Biological Sciences.

(RNAi) a mechanism, either natural or the result of biotechnological manipulation, by which RNA suppresses or interferes with the expression of a gene or genes. Its possible role in...

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RNase III

Overview page. Subjects: Chemistry.

A dsRNase such as Dicer and Drosha involved in the production of siRNA and miRNA respectively. See also ribonuclease.

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short interfering RNA

Overview page. Subjects: Biological Sciences.

Any of several types of small RNA molecules that are produced in cells from double-stranded (ds) precursors by the action of the protein Dicer. This cuts the precursor to form a...

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small interfering RNA

Overview page. Subjects: Genetics and Genomics — Chemistry.

SiRNA)

Small double-stranded RNA molecules (20–25 bp) that interfere with the expression of particular mRNAs (RNA interference) and can also activate innate immune systems that...

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stRNA

Overview page. Subjects: Genetics and Genomics — Chemistry.

abbr. for small temporal RNA; a form of microRNA (see miRNA) that is ≈22 nt long and derived from dsRNA by the endonuclease activity of Dicer and Argonaute. It is highly...

See overview in Oxford Index