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haemochromatosis

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desferrioxamine

Overview page. Subjects: Medicine and Health.

n. a drug that combines with iron in body tissues and fluids and is used to treat iron poisoning, iron overload (including that resulting from prolonged or constant blood...

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diabetes

Overview page. Subjects: Medicine and Health.

n. any disorder of metabolism causing excessive thirst and the production of large volumes of urine. Used alone, the term most commonly refers to diabetes mellitus. See also di...

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ferroportin

Overview page. Subjects: Medicine and Health.

A transmembrane iron transporter (SLC40A1, solute carrier family 40, member 1, 571 aa) with highest level of expression in human placenta (probably transporting iron from mother to fetus),...

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haemojuvelin

Overview page. Subjects: Medicine and Health.

Cell surface protein in liver that senses body iron reserves and controls the synthesis of hepcidin; mutations are associated with juvenile haemochromatosis.

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haemosiderin

Overview page. Subjects: Medicine and Health.

n. an iron-storage compound found mainly in the cells of the macrophage- monocyte system in the marrow, in the Kupffer cells of the liver, and in the spleen. It contains around...

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hemosiderosis

Overview page. Subjects: Chemistry.

or (esp. Brit.)

an abnormal increase in tissue iron content due to some defect in the control of iron turnover in the body or to increased iron ingestion. In...

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heterozygote Advantage

Overview page. Subjects: Genetics and Genomics.

The situation where the heterozygote has a greater fitness than either homozygote. See cystic fibrosis, glucose-6-phosphate dehydrogenase deficiency, hemochromatosis, Indy, overdominance,...

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iron storage

Overview page. Subjects: Medicine and Health.

Ferritin is the iron storage protein in the intestinal mucosa, liver, spleen, and bone marrow. It is a ferric hydroxide-phosphate-protein complex containing 23% iron. Haemosiderin is a...

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liver disorders

Overview page. Subjects: Medicine and Health.

The liver is the major site of many basic metabolic functions and the cells (hepatocytes) appear relatively unspecialized, the archetypal animal cell of textbooks. Liver is one of the few...

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pombé

Overview page. Subjects: Medicine and Health.

African beer prepared from millet; also known as kaffir beer. Commonly associated with iron overload, since it is frequently brewed in iron drums, and alcohol increases the absorption of...

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receptor disorders

Overview page. Subjects: Medicine and Health.

A significant number of disorders arise because of mutation in receptors, in some cases blocking the normal signalling pathway simply because the receptor is absent or does not bind ligand,...

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siderosis

Overview page. Subjects: Medicine and Health.

n. the deposition of iron oxide dust in the lungs, occurring in silver finishers, arc welders, and haematite miners. Iron oxide itself is inert, but pulmonary fibrosis may...

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Vibrio

Overview page. Subjects: Biological Sciences — Medicine and Health.

n. a genus of Gram-negative motile comma-shaped bacteria widely distributed in soil and water. Most species are saprophytic but some are parasites, including V. cholerae, which...

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