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B-cell receptor

Overview page. Subjects: Biological Sciences — Medicine and Health.

An assembly of proteins, attached to the plasma membrane of a B cell, that binds specific extracellular antigen. This activates an intracellular signal pathway that ultimately leads to...

See overview in Oxford Index

Bruton's agammaglobulinaemia

Overview page. Subjects: Medicine and Health.

A sex-linked agammaglobulinaemia caused by defective B cell function because of a mutation in the gene encoding Bruton's tyrosine kinase (btk, 659 aa), one of the Tec family. Btk interacts...

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csk

Overview page. Subjects: Medicine and Health.

Protein tyrosine kinase (c-src kinase, EC 2.7.10.2, 450 aa) that specifically phosphorylates Tyr-504 on lck, which has an inhibitory effect. Can act similarly on lyn and fyn kinases.

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HS1

Overview page. Subjects: Medicine and Health.

1. An actin-binding protein (haematopoietic-specific protein-1, haematopoietic cell-specific LYN substrate 1, 486 aa) homologous to cortactin and restricted to leucocytes....

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latent membrane proteins

Overview page. Subjects: Medicine and Health.

(LMPs)

Oncogenic viral proteins expressed in Epstein–Barr virus (EBV)-associated Hodgkin's lymphoma and nasopharyngeal carcinoma. They interact with various intracellular...

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LIME

Overview page. Subjects: Medicine and Health.

Lck-interacting transmembrane adaptor (295 aa) that becomes tyrosine-phosphorylated by lyn when the B-cell receptor is crosslinked and triggers B-cell activation. LIME is associated with...

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src

Overview page. Subjects: Chemistry.

The oncogene of the Rous sarcoma virus (q.v.). The human SRC gene lies at 20 q12-q13, while the Drosophila Src gene is on the third chromosome at 64B. Src genes encode proteins that...

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src family

Overview page. Subjects: Medicine and Health — Biological Sciences.

A family of protein tyrosine kinases involved in cellular control, src having been the first one described (see src gene). All cells have one at least of these kinases which have...

See overview in Oxford Index