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phospholipase

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ADP-ribosylation factor

Overview page. Subjects: Chemistry.

A protein that acts as activator for ADP‐ribosyltransferase.

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ammodytoxins

Overview page. Subjects: Medicine and Health.

(atx)

Toxins (atx-A, -B, -C, ammodytin L) found in the venom of the southern European viper Vipera ammodytes. They are secreted phospholipases A2 (122 aa) that act presynaptically...

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bungarotoxin

Overview page. Subjects: Medicine and Health — Chemistry.

Neurotoxins from the venom of the multibanded krait Bungarus multicinctus. α-Bungarotoxin (74 aa) binds to the α subunits of the postsynaptic nicotinic acetycholine receptors (nAChR)...

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deteriosome

Overview page. Subjects: Chemistry.

A microvesicle that is found in eukaryotic cells and is rich in phospholipase A2 (see phospholipase). It is believed to represent a stage in membrane degradation.

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fibroblast growth factor receptor

Overview page. Subjects: Chemistry.

A family of tyrosine kinase receptors sharing a common protein structure. Binding of FGF to the receptor results in activation of the tyrosine kinase signalling pathways for cell...

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G protein

Overview page. Subjects: Chemistry — Biological Sciences.

Any one of a group of proteins that relay signals in mammalian cells (see signal transduction). They occur on the inner surface of the plasma membrane and transmit signals from receptors on...

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infantile neuroaxonal dystrophy

Overview page. Subjects: Medicine and Health.

A neurodegenerative disease, characterized by axonal swelling and spheroid bodies in the central nervous system, caused, in many cases, by mutation in the gene for phospholipase A2-G6....

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inositol

Overview page. Subjects: Science and Mathematics — Medicine and Health.

n. a compound, similar to a hexose sugar, that is a constituent of some cell phospholipids. Inositol is present in many foods, in particular in the bran of cereal grain. It is...

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inositol phosphate

Overview page. Subjects: Chemistry.

Any phosphoric ester of an inositol, but normally referring to the esters of myo‐inositol (abbr.: Ins). Of particular interest are those formed by the hydrolysis of membrane...

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lecithinase

Overview page. Subjects: Medicine and Health — Chemistry.

n. an enzyme from the small intestine that breaks lecithin down into glycerol, fatty acids, phosphoric acid, and choline.

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lipase

Overview page. Subjects: Medicine and Health.

(steapsin) n. an enzyme, produced by the pancreas and the glands of the small intestine, that breaks down fats into glycerol and fatty acids during digestion.

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mastoparan

Overview page. Subjects: Chemistry — Medicine and Health.

Basic tetradecapeptides found in wasp venoms. Like melittin they can act as phospholipase A2 activators and some have antimicrobial properties.

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notexin

Overview page. Subjects: Medicine and Health — Chemistry.

Phospholipase A2 isoforms (notexins Np and Ns, 119 aa) that are found in the venom of the tiger snake Notexis scutatus scutatus. They act (slowly) by blocking acetylcholine release at the...

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phosphodiesterase

Overview page. Subjects: Chemistry — Medicine and Health.

(PDE)

Any enzyme that catalyses the hydrolysis of one of the two ester linkages in a phosphodiester. PDE-I (EC 3.1.4.1) catalyses the removal of 5-nucleotides from the 3′-end of an...

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PLC

Overview page. Subjects: Chemistry.

abbr. for

1 preparative‐layer chromatography.

2 phospholipase C; see phospholipase.

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PLD

Overview page. Subjects: Medicine and Health.

1. See phospholipase D.

2. Pegylated liposomal doxorubicin.

3. PLD-118 is an antifungal drug, a synthetic derivative of the β-amino...

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profilin

Overview page. Subjects: Chemistry.

An actin-monomer binding protein (140 aa) that forms an assembly-incompetent complex. The profilin–actin complex is dissociated by phosphatidylinositol bisphosphate. There are two isoforms,...

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protein kinase C

Overview page. Subjects: Chemistry.

A protein that can move from the cytoplasm of a neuron to the membrane, changing the neuron's electrical and molecular properties and increasing its propensity to respond to stimulation by...

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second messenger

Overview page. Subjects: Science and Mathematics — Medicine and Health.

An organic molecule that acts within a cell to initiate the response to a signal carried by a chemical messenger (e.g. a hormone) that does not itself enter the cell. Examples of second...

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