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ezrin

Overview page. Subjects: Chemistry — Medicine and Health.

An actin-binding protein (villin-2, cytovillin, 586 aa) that links the plasma membrane and microfilament bundles in microvilli of intestinal epithelium and elsewhere. Cytovillin (which is...

See overview in Oxford Index

focal adhesions

Overview page. Subjects: Medicine and Health.

Punctate adhesions (~1 × 0.2 μm) of cells with matrix-coated substratum, associated with intracellular microfilament bundles (stress fibres) and a complex of proteins such as vinculin and...

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kindlin

Overview page. Subjects: Medicine and Health.

A family of adaptor proteins associated with focal adhesions and involved in activation of integrins by talin (inside-out signalling) and for the outside-in signalling through integrins...

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merlin

Overview page. Subjects: Medicine and Health — Chemistry.

The protein product (schwannomin, neurofibromin 2, 587 aa) of the neurofibromatosis 2 (NF2) tumour suppressor gene, one of the ERM (ezrin–radixin–moesin) family of proteins that link the...

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nexilin

Overview page. Subjects: Medicine and Health.

An actin filament-binding protein that was identified in rat cell-matrix adherens junctions, colocalizing with vinculin, talin, and paxillin. Two splice variants were isolated from brain...

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podosomes

Overview page. Subjects: Medicine and Health.

Specialized adhesion complexes of osteoclasts that form a broad ring of contacts with the underlying bone; the encircled area below the cell is then absorbed. Contain vinculin, talin,...

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TERM

Overview page. Subjects: Chemistry.

A family of F‐actin binding proteins, named from talin and the related proteins ezrin, radixin, and moesin.

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vinculin

Overview page. Subjects: Chemistry.

A fibrous protein responsible for anchorage of actin filaments to the inner side of the cell membrane. Vinculin is located in patches called adhesion plaques on the cell membrane that are...

See overview in Oxford Index