Oxford Index Search Results

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��-sarcin x clear all

The Influence of Base Identity and Base Pairing on the Function of the α-Sarcin Loop of 23S rRNA

Michael O'Connor and Albert E. Dahlberg.

in Nucleic Acids Research

July 1996; p ublished online July 1996 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 3049 words.

The α-sarcin loop of large subunit rRNAs is one of the sites of interaction of elongation factors with the ribosome, and the target of the cytotoxins α-sarcin and ricin. Using a genetic...

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Production and characterization of a colon cancer-specific immunotoxin based on the fungal ribotoxin α-sarcin

Nelson Carreras-Sangrà, Jaime Tomé-Amat, Lucía García-Ortega, Carl A. Batt, Mercedes Oñaderra, Álvaro Martínez-del-Pozo, José G. Gavilanes and Javier Lacadena.

in Protein Engineering, Design and Selection

August 2012; p ublished online June 2012 .

Journal Article. Subjects: Proteins. 5898 words.

A single-chain fusion protein that directed the cytolytic activity of α-sarcin to A33 tumor antigen expressing cells was constructed and shown to effectively kill targeted cells....

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A deimmunised form of the ribotoxin, α-sarcin, lacking CD4<sup>+</sup> T cell epitopes and its use as an immunotoxin warhead

Tim D. Jones, Arron R. Hearn, Robert G.E. Holgate, Dorota Kozub, Mark H. Fogg, Francis J. Carr, Matthew P. Baker, Javier Lacadena and Kurt R. Gehlsen.

in Protein Engineering, Design and Selection

November 2016; p ublished online October 2016 .

Journal Article. Subjects: Proteins. 7913 words.

Fungal ribotoxins that block protein synthesis can be useful warheads in the context of a targeted immunotoxin. α-Sarcin is a small (17 kDa) fungal ribonuclease produced by Aspergillus...

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Ribonuclease U2: cloning, production in <i>Pichia pastoris</i> and affinity chromatography purification of the active recombinant protein

Antonio Martínez-Ruiz, Lucía García-Ortega, Richard Kao, Mercedes Oñaderra, José M. Mancheño, Julian Davies, Álvaro Martínez del Pozo and José G. Gavilanes.

in FEMS Microbiology Letters

August 2000; p ublished online January 2006 .

Journal Article. 2392 words.

RNase U2 is an endoribonuclease secreted by the fungus Ustilago sphaerogena. Its genomic DNA (rnu2), containing an intron of 116 bp, has been isolated and cloned. The corresponding cDNA has...

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Domain swapping in ribonuclease T1 allows the acquisition of double-stranded activity

Dow-Tien Chen and Alan Lin.

in Protein Engineering, Design and Selection

December 2002; p ublished online December 2002 .

Journal Article. Subjects: Proteins. 5369 words.

A mutant of ribonuclease T1 (RNase T1), denoted RNase Tα, that is designed to recognize double-stranded ribonucleic acid was created. RNase Tα carries the structure of RNase T1 except for a...

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Modeling RNA tertiary structure motifs by graph-grammars

Karine St-Onge, Philippe Thibault, Sylvie Hamel and François Major.

in Nucleic Acids Research

March 2007; p ublished online February 2007 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6342 words.

A new approach, graph-grammars, to encode RNA tertiary structure patterns is introduced and exemplified with the classical sarcin–ricin motif. The sarcin–ricin motif is found in the stem of...

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aspergillin

Overview page. Subjects: Medicine and Health.

1. A name sometimes given to the black spore pigment produced by Aspergillus niger.

2. A name occasionally used for toxins (ribonucleases) produced by Asp...

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Mechanism of ribosome RNA apurinic site specific lyase

Tatsuya Sawasaki, Ryo Morishita, Akihiko Ozawa, Tomio Ogasawara, Kairat Madin and Yaeta Endo.

in Nucleic Acids Symposium Series

November 1999; p ublished online November 1999 .

Journal Article. Subjects: Chemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 0 words.

A new enzyme, which we named ribosome RNA apurinic site specific lyase (RALyase), has been characterized. The enzyme specifically cleaves a phosphodiester bond at the apurinic site in the...

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Clustering RNA structural motifs in ribosomal RNAs using secondary structural alignment

Cuncong Zhong and Shaojie Zhang.

in Nucleic Acids Research

February 2012; p ublished online October 2011 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 7200 words.

RNA structural motifs are the building blocks of the complex RNA architecture. Identification of non-coding RNA structural motifs is a critical step towards understanding of their...

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Cinnamomin—a Versatile Type II Ribosome-inactivating Protein

Hong Xu and Wang-Yi Liu.

Edited by Guo-Rong Qi.

in Acta Biochimica et Biophysica Sinica

March 2004; p ublished online March 2004 .

Journal Article. Subjects: Biochemistry. 0 words.

Ribosome-inactivating proteins (RIPs) are a group of toxic proteins that can specifically act on the universally conserved sarcin/ricin domain (S/R domain) of the largest RNA in ribosome...

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