Oxford Index Search Results

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��-sarcin x clear all

The C-terminal fragment of the ribosomal P protein complexed to trichosanthin reveals the interaction between the ribosome-inactivating protein and the ribosome

Priscilla Hiu-Mei Too, Meiji Kit-Wan Ma, Amanda Nga-Sze Mak, Yuen-Ting Wong, Christine Kit-Ching Tung, Guang Zhu, Shannon Wing-Ngor Au, Kam-Bo Wong and Pang-Chui Shaw.

in Nucleic Acids Research

February 2009; p ublished online December 2008 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 4277 words.

Ribosome-inactivating proteins (RIPs) inhibit protein synthesis by enzymatically depurinating a specific adenine residue at the sarcin-ricin loop of the 28S rRNA, which thereby prevents the...

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Generation of pokeweed antiviral protein mutations in <i>Saccharomyces cerevisiae</i>: evidence that ribosome depurination is not sufficient for cytotoxicity

Katalin A. Hudak, Bijal A. Parikh, Rong Di, Marianne Baricevic, Maria Santana, Mirjana Seskar and Nilgun E. Tumer.

in Nucleic Acids Research

August 2004; p ublished online August 2004 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 9833 words.

Pokeweed antiviral protein (PAP) is a ribosome-inactivating protein that depurinates the highly conserved α-sarcin/ricin loop in the large rRNA. Here, using site-directed mutagenesis and...

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Pokeweed antiviral protein cleaves double-stranded supercoiled DNA using the same active site required to depurinate rRNA

Pinger Wang and Nilgun E. Tumer.

in Nucleic Acids Research

April 1999; p ublished online April 1999 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 4761 words.

Ribosome-inactivating proteins (RIPs) are N-glycosylases that remove a specific adenine from the sarcin/ricin loop of the large rRNA in a manner analogous to N-glycosylases that are...

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Computational identification of RNA functional determinants by three-dimensional quantitative structure–activity relationships

Marc-Frédérick Blanchet, Karine St-Onge, Véronique Lisi, Julie Robitaille, Sylvie Hamel and François Major.

in Nucleic Acids Research

September 2014; p ublished online September 2014 .

Journal Article. Subjects: Molecular and Cell Biology; Bioinformatics and Computational Biology. 6069 words.

Anti-infection drugs target vital functions of infectious agents, including their ribosome and other essential non-coding RNAs. One of the reasons infectious agents become resistant to...

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Chemical probing of RNA with the hydroxyl radical at single-atom resolution

Shakti Ingle, Robert N. Azad, Swapan S. Jain and Thomas D. Tullius.

in Nucleic Acids Research

November 2014; p ublished online October 2014 .

Journal Article. Subjects: Molecular and Cell Biology. 7522 words.

While hydroxyl radical cleavage is widely used to map RNA tertiary structure, lack of mechanistic understanding of strand break formation limits the degree of structural insight that can be...

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A switch-on mechanism to activate maize ribosome-inactivating protein for targeting HIV-infected cells

Sue Ka-Yee Law, Rui-Rui Wang, Amanda Nga-Sze Mak, Kam-Bo Wong, Yong-Tang Zheng and Pang-Chui Shaw.

in Nucleic Acids Research

October 2010; p ublished online June 2010 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 5868 words.

Maize ribosome-inactivating protein (RIP) is a plant toxin that inactivates eukaryotic ribosomes by depurinating a specific adenine residue at the α-sarcin/ricin loop of 28S rRNA. Maize RIP...

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RNAMotifScan: automatic identification of RNA structural motifs using secondary structural alignment

Cuncong Zhong, Haixu Tang and Shaojie Zhang.

in Nucleic Acids Research

October 2010; p ublished online August 2010 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6646 words.

Recent studies have shown that RNA structural motifs play essential roles in RNA folding and interaction with other molecules. Computational identification and analysis of RNA structural...

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WebFR3D—a server for finding, aligning and analyzing recurrent RNA 3D motifs

Anton I. Petrov, Craig L. Zirbel and Neocles B. Leontis.

in Nucleic Acids Research

July 2011; p ublished online April 2011 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 2863 words.

WebFR3D is the on-line version of ‘Find RNA 3D’ (FR3D), a program for annotating atomic-resolution RNA 3D structure files and searching them efficiently to locate and compare RNA 3D...

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Functional interaction between bases C1049 in domain II and G2751 in domain VI of 23S rRNA in <i>Escherichia coli</i> ribosomes

Tomohiro Miyoshi and Toshio Uchiumi.

in Nucleic Acids Research

April 2008; p ublished online February 2008 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 5522 words.

The factor-binding center within the Escherichia coli ribosome is comprised of two discrete domains of 23S rRNA: the GTPase-associated region (GAR) in domain II and the sarcin–ricin loop in...

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Interaction between trichosanthin, a ribosome-inactivating protein, and the ribosomal stalk protein P2 by chemical shift perturbation and mutagenesis analyses

Denise S.B. Chan, Lai-On Chu, Ka-Ming Lee, Priscilla H.M. Too, Kit-Wan Ma, Kong-Hung Sze, Guang Zhu, Pang-Chui Shaw and Kam-Bo Wong.

in Nucleic Acids Research

March 2007; p ublished online February 2007 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 7254 words.

Trichosanthin (TCS) is a type I ribosome-inactivating protein that inactivates ribosome by enzymatically depurinating the A4324 at the α-sarcin/ricin loop of 28S rRNA. We have shown in this...

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