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α-sarcin

Overview page. Subjects: Chemistry.

A cytotoxin produced by Aspergillus giganteus. It has ribonuclease activity, specific for purines in both single‐stranded and double‐stranded RNA. It inhibits protein synthesis, cleaving a...

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Comparative Induction of 28S Ribosomal RNA Cleavage by Ricin and the Trichothecenes Deoxynivalenol and T-2 Toxin in the Macrophage

Maoxiang Li and James J. Pestka.

in Toxicological Sciences

September 2008; p ublished online June 2008 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 5900 words.

Ribosome-inactivating proteins (RIPs) and sesquiterpenoid trichothecene mycotoxins are known to bind to eukaryotic ribosomes, inhibit translation and activate mitogen-activated protein...

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