Oxford Index Search Results

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α-sarcin

Overview page. Subjects: Chemistry.

A cytotoxin produced by Aspergillus giganteus. It has ribonuclease activity, specific for purines in both single‐stranded and double‐stranded RNA. It inhibits protein synthesis, cleaving a...

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sarcin/ricin loop

Overview page. Subjects: Medicine and Health.

A highly conserved sequence found in the 28S RNA of the large subunit of the ribosome. It is cleaved by both *α-sarcin and ricin which prevents elongation factor from binding and thus...

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alpha-sarcin

John Lackie.

in A Dictionary of Biomedicine

January 2010; p ublished online January 2010 .

Reference Entry. Subjects: Clinical Medicine. 36 words.

A cytotoxic compound (177 aa) from Aspergillus giganteus that has ribonuclease activity and cleaves a single oligonucleotide from the 3′

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Molecular dynamics simulations of sarcin–ricin rRNA motif

Nad'a Špačková and Jiří Šponer.

in Nucleic Acids Research

January 2006; p ublished online January 2006 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 9272 words.

Explicit solvent molecular dynamics (MD) simulations were carried out for sarcin–ricin domain (SRD) motifs from 23S (Escherichia coli) and 28S (rat) rRNAs. The SRD motif consists of GAGA...

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α-sarcin

Overview page. Subjects: Chemistry.

A cytotoxin produced by Aspergillus giganteus. It has ribonuclease activity, specific for purines in both single‐stranded and double‐stranded RNA. It inhibits protein synthesis, cleaving a...

See overview in Oxford Index

sarcin/ricin loop

John Lackie.

in A Dictionary of Biomedicine

January 2010; p ublished online January 2010 .

Reference Entry. Subjects: Clinical Medicine. 36 words.

A highly conserved sequence found in the 28S RNA of the large subunit of the ribosome. It is cleaved by

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α‐sarcin

Edited by Richard Cammack, Teresa Atwood, Peter Campbell, Howard Parish, Anthony Smith, Frank Vella and John Stirling.

in Oxford Dictionary of Biochemistry and Molecular Biology

January 2006; p ublished online January 2008 .

Reference Entry. Subjects: Biochemistry. 91 words.

a cytotoxin produced by Aspergillus giganteus. It has ribonuclease activity, specific for purines in both single‐stranded and double‐stranded RNA.

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Effects of Antisense DNA Against the α-Sarcin Stem-Loop Structure of the Ribosomal 23S rRNA

Hellmuth-Alexander Meyer, Francisco Triana-Alonso, Christian M. T. Spahn, Tomasz Twardowski, Andrzej Sobkiewicz and Knud H. Nierhaus.

in Nucleic Acids Research

October 1996; p ublished online October 1996 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 4598 words.

Antisense DNAs complementary against various sequences of the α-sarcin domain (C2646-G2674) of 23S rRNA from Escherichia coli were hybridized to naked 23S rRNA as well as to 70S ribosomes....

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A deimmunised form of the ribotoxin, α-sarcin, lacking CD4<sup>+</sup> T cell epitopes and its use as an immunotoxin warhead

Tim D. Jones, Arron R. Hearn, Robert G.E. Holgate, Dorota Kozub, Mark H. Fogg, Francis J. Carr, Matthew P. Baker, Javier Lacadena and Kurt R. Gehlsen.

in Protein Engineering, Design and Selection

November 2016; p ublished online October 2016 .

Journal Article. Subjects: Proteins. 7913 words.

Fungal ribotoxins that block protein synthesis can be useful warheads in the context of a targeted immunotoxin. α-Sarcin is a small (17 kDa) fungal ribonuclease produced by Aspergillus...

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Cleavage of the sarcin–ricin loop of 23S rRNA differentially affects EF-G and EF-Tu binding

Lucía García-Ortega, Elisa Álvarez-García, José G. Gavilanes, Álvaro Martínez-del-Pozo and Simpson Joseph.

in Nucleic Acids Research

July 2010; p ublished online March 2010 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 7930 words.

Ribotoxins are potent inhibitors of protein biosynthesis and inactivate ribosomes from a variety of organisms. The ribotoxin α-sarcin cleaves the large 23S ribosomal RNA (rRNA) at the...

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Production and characterization of a colon cancer-specific immunotoxin based on the fungal ribotoxin α-sarcin

Nelson Carreras-Sangrà, Jaime Tomé-Amat, Lucía García-Ortega, Carl A. Batt, Mercedes Oñaderra, Álvaro Martínez-del-Pozo, José G. Gavilanes and Javier Lacadena.

in Protein Engineering, Design and Selection

August 2012; p ublished online June 2012 .

Journal Article. Subjects: Proteins. 5898 words.

A single-chain fusion protein that directed the cytolytic activity of α-sarcin to A33 tumor antigen expressing cells was constructed and shown to effectively kill targeted cells....

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