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α-sarcin

Overview page. Subjects: Chemistry.

A cytotoxin produced by Aspergillus giganteus. It has ribonuclease activity, specific for purines in both single‐stranded and double‐stranded RNA. It inhibits protein synthesis, cleaving a...

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Molecular dynamics simulations of sarcin–ricin rRNA motif

Nad'a Špačková and Jiří Šponer.

in Nucleic Acids Research

January 2006; p ublished online January 2006 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 9272 words.

Explicit solvent molecular dynamics (MD) simulations were carried out for sarcin–ricin domain (SRD) motifs from 23S (Escherichia coli) and 28S (rat) rRNAs. The SRD motif consists of GAGA...

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Effects of Antisense DNA Against the α-Sarcin Stem-Loop Structure of the Ribosomal 23S rRNA

Hellmuth-Alexander Meyer, Francisco Triana-Alonso, Christian M. T. Spahn, Tomasz Twardowski, Andrzej Sobkiewicz and Knud H. Nierhaus.

in Nucleic Acids Research

October 1996; p ublished online October 1996 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 4598 words.

Antisense DNAs complementary against various sequences of the α-sarcin domain (C2646-G2674) of 23S rRNA from Escherichia coli were hybridized to naked 23S rRNA as well as to 70S ribosomes....

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Cleavage of the sarcin–ricin loop of 23S rRNA differentially affects EF-G and EF-Tu binding

Lucía García-Ortega, Elisa Álvarez-García, José G. Gavilanes, Álvaro Martínez-del-Pozo and Simpson Joseph.

in Nucleic Acids Research

July 2010; p ublished online March 2010 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 7930 words.

Ribotoxins are potent inhibitors of protein biosynthesis and inactivate ribosomes from a variety of organisms. The ribotoxin α-sarcin cleaves the large 23S ribosomal RNA (rRNA) at the...

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Placement of the α-sarcin loop within the 50S subunit: Evidence derived using a photolabile oligodeoxynucleotide probe

Parimi Muralikrishna, Rebecca W. Alexander and Barry S. Cooperman.

in Nucleic Acids Research

November 1997; p ublished online November 1997 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 4915 words.

We report the synthesis of a radioactive, photolabile oligodeoxyribonucleotide probe and its exploitation in identifying 50S ribosomal subunit components neighboring the α-sarcin loop. The...

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The Influence of Base Identity and Base Pairing on the Function of the α-Sarcin Loop of 23S rRNA

Michael O'Connor and Albert E. Dahlberg.

in Nucleic Acids Research

July 1996; p ublished online July 1996 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 3049 words.

The α-sarcin loop of large subunit rRNAs is one of the sites of interaction of elongation factors with the ribosome, and the target of the cytotoxins α-sarcin and ricin. Using a genetic...

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Biochemical evidence of translational infidelity and decreased peptidyltransferase activity by a sarcin/ricin domain mutation of yeast 25S rRNA

Panagiotis Panopoulos, John Dresios and Dennis Synetos.

in Nucleic Acids Research

October 2004; p ublished online October 2004 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 9181 words.

A C→U mutation (rdn5) in the conserved sarcin/ricin domain of yeast 25S rRNA has been shown to cause translational suppression and paromomycin resistance. It also separates the killing from...

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Chemical probing of RNA with the hydroxyl radical at single-atom resolution

Shakti Ingle, Robert N. Azad, Swapan S. Jain and Thomas D. Tullius.

in Nucleic Acids Research

November 2014; p ublished online October 2014 .

Journal Article. Subjects: Molecular and Cell Biology. 7522 words.

While hydroxyl radical cleavage is widely used to map RNA tertiary structure, lack of mechanistic understanding of strand break formation limits the degree of structural insight that can be...

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Modeling RNA tertiary structure motifs by graph-grammars

Karine St-Onge, Philippe Thibault, Sylvie Hamel and François Major.

in Nucleic Acids Research

March 2007; p ublished online February 2007 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6342 words.

A new approach, graph-grammars, to encode RNA tertiary structure patterns is introduced and exemplified with the classical sarcin–ricin motif. The sarcin–ricin motif is found in the stem of...

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Computational identification of RNA functional determinants by three-dimensional quantitative structure–activity relationships

Marc-Frédérick Blanchet, Karine St-Onge, Véronique Lisi, Julie Robitaille, Sylvie Hamel and François Major.

in Nucleic Acids Research

September 2014; p ublished online September 2014 .

Journal Article. Subjects: Molecular and Cell Biology; Bioinformatics and Computational Biology. 6069 words.

Anti-infection drugs target vital functions of infectious agents, including their ribosome and other essential non-coding RNAs. One of the reasons infectious agents become resistant to...

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Mechanism of ribosome RNA apurinic site specific lyase

Tatsuya Sawasaki, Ryo Morishita, Akihiko Ozawa, Tomio Ogasawara, Kairat Madin and Yaeta Endo.

in Nucleic Acids Symposium Series

November 1999; p ublished online November 1999 .

Journal Article. Subjects: Chemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 0 words.

A new enzyme, which we named ribosome RNA apurinic site specific lyase (RALyase), has been characterized. The enzyme specifically cleaves a phosphodiester bond at the apurinic site in the...

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