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bumetanide

Overview page. Subjects: Clinical Pharmacology and Therapeutics.

A potent loop diuretic that inhibits sodium reabsorption in the ascending limb of the loop of Henle.

See overview in Oxford Index

Beneficial effects of bumetanide in a CaV1.1-R528H mouse model of hypokalaemic periodic paralysis

Fenfen Wu, Wentao Mi and Stephen C. Cannon.

in Brain

December 2013; p ublished online October 2013 .

Journal Article. Subjects: Neurology; Neuroscience. 5004 words.

Transient attacks of weakness in hypokalaemic periodic paralysis are caused by reduced fibre excitability from paradoxical depolarization of the resting potential in low potassium....

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NT-11TARGETING INTERSTITIAL FLUID PRESSURE TO REDUCE TUMOR GROWTH AND INCREASE DRUG UPTAKE IN BRAIN TUMORS

Shirin Ilkhanizadeh, Yekaterina Miroshnikova, Aaron Frantz, David James, Mitchel Berger, Tracy McKnight, Valerie Weaver, William Weiss and Anders Persson.

in Neuro-Oncology

November 2014; p ublished online November 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

High interstitial fluid pressure (IFP) represents a barrier for drug uptake in human GBM, the most common malignant primary brain tumor in adults. Increased IFP is due to leakiness of blood...

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CB-15NKCC1 REGULATES MIGRATION CAPACITY OF GLIOBLASTOMA TUMOR INITIATING CELLS BY MODULATING ACTIN CYTOSKELETON THROUGH SMALL RHO GTPASES

Paula Schiapparelli, Roxana Magana-Maldonado, Susan Hamilla, Leslie Sibener, Juan Carlos Martinez-Gutierrez, Helim Aranda-Espinoza and Alfredo Quinones-Hinojosa.

in Neuro-Oncology

November 2014; p ublished online November 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Glioblastoma (GBM) is a highly invasive and lethal brain tumor due to its high invasion and recurrence. The mechanisms that confer GBM cells their invasive behavior and their regulatory...

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EXTH-23. ANTISECRETORY FACTOR-MEDIATED LOWERING OF INTERSTITIAL FLUID PRESSURE PRODUCES ANTI-TUMOR ACTIVITY IN GLIOBLASTOMA

Hanna Sabelstrom, Shirin IIkhanizadeh, Yekaterina A Miroshnikova, Aaron Frantz, Wen Zhu, Aurora Idilli, David Quigley, Trenten Fenster, Edith Yuan, Supna Saxena, Janna K Mouw, Jason A Burdick, Sergey Magnitsky, Mitchel S Berger, Daniele Arosio, Dandan Sun, Valerie M Weaver, William A Weiss and Anders I Persson.

in Neuro-Oncology

November 2017; p ublished online November 2017 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

Abstract

Glioblastoma (GBM) is among the most aggressive cancers. Although high interstitial fluid pressure presents a barrier to drug uptake, how mechanical...

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Neuronal chloride accumulation and excitatory GABA underlie aggravation of neonatal epileptiform activities by phenobarbital

Romain Nardou, Sumii Yamamoto, Geneviève Chazal, Asma Bhar, Nadine Ferrand, Olivier Dulac, Yehezkel Ben-Ari and Ilgam Khalilov.

in Brain

April 2011; p ublished online March 2011 .

Journal Article. Subjects: Neurology; Neuroscience. 7699 words.

Phenobarbital produces its anti-epileptic actions by increasing the inhibitory drive of γ-aminobutyric acid. However, following recurrent seizures, γ-aminobutyric acid excites neurons...

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HIGH INTERSTITIAL FLUID PRESSURE REGULATES TUMOR GROWTH AND DRUG UPTAKE IN HUMAN GLIOBLASTOMA

Anders I. Persson, Shirin Ilkhanizadeh, Yekaterina A. Miroshnikova, Aaron Frantz, John N. Lakins, C. David James, Tracy R. McKnight, Mitchel S. Berger, Gabriele Bergers, William A. Weiss and Valerie M. Weaver.

in Neuro-Oncology

July 2014; p ublished online July 2014 .

Journal Article. Subjects: Medical Oncology; Neurology. 0 words.

BACKGROUND: (blind field). METHODS: We developed methodology to measure IFP in human GBM xenografts and mechanical compression in 3D-cultures. We used a cell counter and calcein-AM-loaded...

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