Oxford Index Search Results

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tools x Proteins x clear all

Tool

Overview page. Subjects: Music.

One of the leading US alternative metal acts to emerge from the 90s, Tool was formed in Los Angeles, California, in 1990 by Adam Jones (b. 15 January 1965, Libertyville ...

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A web-based tool for rational screening of mutants libraries using ProSAR

Magali Berland, Bernard Offmann, Isabelle André, Magali Remaud-Siméon and Philippe Charton.

in Protein Engineering, Design and Selection

October 2014; p ublished online August 2014 .

Journal Article. Subjects: Proteins. 3367 words.

In directed evolution experiments, it is at stake to have methods to screen efficiently the mutant libraries. We propose a web-based tool that implements an established in silico method for...

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Molecular dynamics simulations as a tool for improving protein stability

Mariël G. Pikkemaat, Antonius B.M. Linssen, Herman J.C. Berendsen and Dick B. Janssen.

in Protein Engineering, Design and Selection

March 2002; p ublished online March 2002 .

Journal Article. Subjects: Proteins. 6871 words.

Haloalkane dehalogenase (DhlA) was used as a model protein to explore the possibility to use molecular dynamics (MD) simulations as a tool to identify flexible regions in proteins that can...

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Sequences annotated by structure: a tool to facilitate the use of structural information in sequence analysis.

D Milburn, R A Laskowski and J M Thornton.

in Protein Engineering, Design and Selection

October 1998; p ublished online October 1998 .

Journal Article. Subjects: Proteins. 0 words.

With the aim of bridging the gap between protein sequence and structural analyses, we have developed a tool to aid the identification of new protein sequences by recognizing distant...

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The effect of chirality and steric hindrance on intrinsic backbone conformational propensities: tools for protein design

Matthew Carter Childers, Clare-Louise Towse and Valerie Daggett.

in Protein Engineering, Design and Selection

July 2016; p ublished online June 2016 .

Journal Article. Subjects: Proteins. 7439 words.

The conformational propensities of amino acids are an amalgamation of sequence effects, environmental effects and underlying intrinsic behavior. Many have attempted to investigate...

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AUTO-MUTE: web-based tools for predicting stability changes in proteins due to single amino acid replacements

Majid Masso and Iosif I. Vaisman.

in Protein Engineering, Design and Selection

August 2010; p ublished online June 2010 .

Journal Article. Subjects: Proteins. 3366 words.

Utilizing cutting-edge supervised classification and regression algorithms, three web-based tools have been developed for predicting stability changes upon single residue substitutions in...

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An evaluation tool for FKBP12-dependent and -independent mTOR inhibitors using a combination of FKBP-mTOR fusion protein, DSC and NMR

Mitsuhiro Sekiguchi, Yoshihiro Kobashigawa, Masashi Kawasaki, Masashi Yokochi, Tetsuo Kiso, Ken-ichi Suzumura, Keitaro Mori, Toshio Teramura and Fuyuhiko Inagaki.

in Protein Engineering, Design and Selection

November 2011; p ublished online September 2011 .

Journal Article. Subjects: Proteins. 3369 words.

Mammalian target of rapamycin (mTOR), a large multidomain protein kinase, regulates cell growth and metabolism in response to environmental signals. The FKBP rapamycin-binding (FRB) domain...

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Nature's recipe for splitting inteins

A.Sesilja Aranko, Alexander Wlodawer and Hideo Iwaï.

in Protein Engineering, Design and Selection

August 2014; p ublished online August 2014 .

Journal Article. Subjects: Proteins. 4853 words.

Protein splicing in trans by split inteins has increasingly become a powerful protein-engineering tool for protein ligation, both in vivo and in vitro. Over 100 naturally occurring and...

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Use of a genetically encoded hydrogen peroxide sensor for whole cell screening of enzyme activity

Joseph B. Lim and Hadley D. Sikes.

in Protein Engineering, Design and Selection

March 2015; p ublished online February 2015 .

Journal Article. Subjects: Proteins. 3682 words.

We report the use of HyPer, a genetically encoded, fluorescent sensor that reacts with hydrogen peroxide (H2O2), in a novel screen to engineer enzymes for enhanced production of H2O2. We...

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Selection of high-affinity Centyrin FN3 domains from a simple library diversified at a combination of strand and loop positions

Michael D. Diem, Linus Hyun, Fang Yi, Randi Hippensteel, Elise Kuhar, Cassandra Lowenstein, Edward J. Swift, Karyn T. O'Neil and Steven A. Jacobs.

in Protein Engineering, Design and Selection

October 2014; p ublished online April 2014 .

Journal Article. Subjects: Proteins. 8897 words.

Alternative scaffold molecules represent a class of proteins important to the study of protein design and mechanisms of protein–protein interactions, as well as for the development of...

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Green fluorescent antibodies: novel <i>in vitro</i> tools

Joanne L. Casey, Andrew M. Coley, Leann M. Tilley and Michael Foley.

in Protein Engineering, Design and Selection

June 2000; p ublished online June 2000 .

Journal Article. Subjects: Proteins. 5008 words.

We produced a fluorescent antibody as a single recombinant protein in Escherichia coli by fusing a red-shifted mutant of green fluorescent protein (EGFP) to a single-chain antibody variable...

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