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DNA-PK

Overview page. Subjects: Chemistry.

abbr. for DNA‐dependent protein kinase; a mammalian nuclear protein serine/threonine kinase involved in DNA replication, transcription, repair of dsDNA breaks, and in V(D)J...

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DNA-PK

John Lackie.

in A Dictionary of Biomedicine

January 2010; p ublished online January 2010 .

Reference Entry. Subjects: Clinical Medicine. 5 words.

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Visualization of a DNA-PK/PARP1 complex

Laura Spagnolo, Jody Barbeau, Nicola J. Curtin, Edward P. Morris and Laurence H. Pearl.

in Nucleic Acids Research

May 2012; p ublished online January 2012 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 5514 words.

The DNA-dependent protein kinase (DNA-PK) and Poly(ADP-ribose) polymerase-1 (PARP1) are critical enzymes that reduce genomic damage caused by DNA lesions. They are both activated by DNA...

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Vanillins—a novel family of DNA‐PK inhibitors

Stephen Durant and Peter Karran.

in Nucleic Acids Research

October 2003; p ublished online October 2003 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 7105 words.

Non‐homologous DNA end‐joining (NHEJ) is a major pathway of double strand break (DSB) repair in human cells. Here we show that vanillin (3‐methoxy‐4‐hydroxybenzaldehyde)—a naturally...

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An autonomous chromatin/DNA-PK mechanism for localized DNA damage signaling in mammalian cells

Denise P. Muñoz, Misako Kawahara and Steven M. Yannone.

in Nucleic Acids Research

March 2013; p ublished online January 2013 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 7306 words.

Rapid phosphorylation of histone variant H2AX proximal to DNA breaks is an initiating event and a hallmark of eukaryotic DNA damage responses. Three mammalian kinases are known to...

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Cisplatin–DNA adducts inhibit translocation of the Ku subunits of DNA-PK

John J. Turchi, Karen M. Henkels and Yun Zhou.

in Nucleic Acids Research

December 2000; p ublished online December 2000 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 5717 words.

We have determined the effect of cisplatin–DNA damage on the ability of the DNA-dependent protein kinase (DNA-PK) to interact with duplex DNA molecules in vitro. The Ku DNA binding subunits...

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Differential activation of DNA-PK based on DNA strand orientation and sequence bias

Katherine S. Pawelczak, Brooke J. Andrews and John J. Turchi.

in Nucleic Acids Research

January 2005; p ublished online January 2005 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 7694 words.

DNA-PKcs and Ku are essential components of the complex that catalyzes non-homologous end joining (NHEJ) of DNA double-strand breaks (DSBs). Ku, a heterodimeric protein, binds to DNA ends...

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Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies

Edward P. Morris, Angel Rivera-Calzada, Paula C. A. da Fonseca, Oscar Llorca, Laurence H. Pearl and Laura Spagnolo.

in Nucleic Acids Research

July 2011; p ublished online March 2011 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6295 words.

The multi-subunit DNA-dependent protein kinase (DNA-PK), a crucial player in DNA repair by non-homologous end-joining in higher eukaryotes, consists of a catalytic subunit (DNA-PKcs) and...

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DNA-PK is essential only for coding joint formation in V(D)J recombination

Piotr Kulesza and Michael R. Lieber.

in Nucleic Acids Research

September 1998; p ublished online September 1998 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 3603 words.

The analysis of the role of DNA-dependent protein kinase (DNA-PK) in DNA double-strand break repair and V(D)J recombination is based primarily on studies of murine scid, in which only the...

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ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses

Jun Yang, Yingnian Yu, Hope E. Hamrick and Penelope J. Duerksen-Hughes.

in Carcinogenesis

October 2003; p ublished online October 2003 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 8928 words.

Exposure to genotoxic agents is a major cause of human cancer, and cellular responses to genotoxic stress are important defense mechanisms. These responses are very complex, involving many...

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DNA‐PK‐dependent binding of DNA ends to plasmids containing nuclear matrix attachment region DNA sequences: evidence for assembly of a repair complex

Stanley K. Mauldin, Robert C. Getts, Wenjing Liu and Thomas D. Stamato.

in Nucleic Acids Research

September 2002; p ublished online September 2002 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 9734 words.

We find that nuclear protein extracts from mammalian cells contain an activity that allows DNA ends to associate with circular pUC18 plasmid DNA. This activity requires the catalytic subunit...

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Selective inhibition of the DNA‐dependent protein kinase (DNA‐PK) by the radiosensitizing agent caffeine

Wesley D. Block, Dennis Merkle, Katheryn Meek and Susan P. Lees‐Miller.

in Nucleic Acids Research

March 2004; p ublished online March 2004 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 4422 words.

Caffeine inhibits cell cycle checkpoints, sensitizes cells to ionizing radiation‐induced cell killing and inhibits the protein kinase activity of two cell cycle checkpoint regulators,...

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DNA-PK

Overview page. Subjects: Chemistry.

abbr. for DNA‐dependent protein kinase; a mammalian nuclear protein serine/threonine kinase involved in DNA replication, transcription, repair of dsDNA breaks, and in V(D)J...

See overview in Oxford Index

DNA‐PK

Edited by Richard Cammack, Teresa Atwood, Peter Campbell, Howard Parish, Anthony Smith, Frank Vella and John Stirling.

in Oxford Dictionary of Biochemistry and Molecular Biology

January 2006; p ublished online January 2008 .

Reference Entry. Subjects: Biochemistry. 48 words.

abbr. for DNA‐dependent protein kinase; a mammalian nuclear protein serine/threonine kinase involved in DNA replication, transcription, repair of dsDNA breaks,

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DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1

Senad Medunjanin, Jan-Marcus Daniel, Sönke Weinert, Jochen Dutzmann, Frank Burgbacher, Sarah Brecht, Dennis Bruemmer, Thilo Kähne, Michael Naumann, Daniel G. Sedding, Werner Zuschratter and Ruediger C. Braun-Dullaeus.

in Cardiovascular Research

June 2015; p ublished online April 2015 .

Journal Article. Subjects: Cardiovascular Medicine. 5173 words.

Aims

Being central part of the DNA repair machinery, DNA-dependent protein kinase (DNA-PK) seems to be involved in other signalling processes, as well. NOR1...

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DNA damage-induced inhibition of rRNA synthesis by DNA-PK and PARP-1

Anne S. Calkins, J. Dirk Iglehart and Jean-Bernard Lazaro.

in Nucleic Acids Research

August 2013; p ublished online June 2013 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 5307 words.

RNA synthesis and DNA replication cease after DNA damage. We studied RNA synthesis using an in situ run-on assay and found ribosomal RNA (rRNA) synthesis was inhibited 24 h after UV light,...

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<i>In cellulo</i> phosphorylation of DNA double-strand break repair protein XRCC4 on Ser260 by DNA-PK

Ali Reza Amiri Moghani, Mukesh Kumar Sharma and Yoshihisa Matsumoto.

in Journal of Radiation Research

November 2018; p ublished online September 2018 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 5485 words.

Abstract

XRCC4 is one of the core factors for DNA double-strand break (DSB) repair through non-homologous end joining (NHEJ). XRCC4 is phosphorylated by...

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DNA-dependent protein kinase (DNA-PK)-deficient human glioblastoma cells are preferentially sensitized by Zebularine

Jarah A. Meador, Yanrong Su, Jean-Luc Ravanat and Adayabalam S. Balajee.

in Carcinogenesis

February 2010; p ublished online November 2009 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 5971 words.

Brain tumor cells respond poorly to radiotherapy and chemotherapy due to inherently efficient anti-apoptotic and DNA repair mechanisms. This necessitates the development of new strategies...

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A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining

Katherine S. Pawelczak and John J. Turchi.

in Nucleic Acids Research

July 2008; p ublished online May 2008 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6057 words.

DNA-dependent protein kinase (DNA-PK) is an essential component of the nonhomologous end joining pathway (NHEJ), responsible for the repair of DNA double-strand breaks. Ku binds a DSB and...

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Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA–PK

Barbara Meyer, Kay-Obbe Voss, Frank Tobias, Burkhard Jakob, Marco Durante and Gisela Taucher-Scholz.

in Nucleic Acids Research

July 2013; p ublished online April 2013 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6748 words.

DNA double-strand breaks (DSB) are considered as the most deleterious DNA lesions, and their repair is further complicated by increasing damage complexity. However, the molecular effects of...

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Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells

Huichen Wang, Zhao-Chong Zeng, Ange R. Perrault, Xinbo Cheng, Wei Qin and George Iliakis.

in Nucleic Acids Research

April 2001; p ublished online April 2001 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6996 words.

Cells of vertebrates remove DNA double-strand breaks (DSBs) from their genome predominantly utilizing a fast, DNA-PKcs-dependent form of non-homologous end joining (D-NHEJ). Mutants with...

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