Oxford Index Search Results

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HMG-CoA x clear all


Overview page. Subjects: Chemistry.

abbr. for hydroxymethylglutaryl‐CoA.

See overview in Oxford Index

Statins inhibit insulin-like growth factor action in first trimester placenta by altering insulin-like growth factor 1 receptor glycosylation

Karen Forbes, Vinit K. Shah, Kirk Siddals, J. Martin Gibson, John D. Aplin and Melissa Westwood.

in MHR: Basic science of reproductive medicine

January 2015; p ublished online October 2014 .

Journal Article. Subjects: Reproductive Medicine. 5044 words.

The rapid rise in obesity, metabolic syndrome and type 2 diabetes is one of the major healthcare problems of the Western world. Affected individuals are often treated with statins...

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Lipid‐lowering‐independent effects of simvastatin on the kidney in experimental hypercholesterolaemia

Stephanie H. Wilson, Alejandro R. Chade, Ariel Feldstein, Tatsuya Sawamura, Claudio Napoli, Amir Lerman and Lilach O. Lerman.

in Nephrology Dialysis Transplantation

April 2003; p ublished online April 2003 .

Journal Article. Subjects: Nephrology. 3497 words.

Background. Hypercholesterolaemia (HC), an independent risk factor for renal injury, is associated with formation of oxidized low‐density‐lipoprotein (ox‐LDL), increased...

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Short‐term effect of atorvastatin in hypercholesterolaemic renal‐transplant patients unresponsive to other statins

Rafael Romero, Jesus Calviño, Javier Rodriguez and Domingo Sánchez‐Guisande.

in Nephrology Dialysis Transplantation

September 2000; p ublished online September 2000 .

Journal Article. Subjects: Nephrology. 2550 words.

Background. Atherosclerosis associated with hyperlipidaemia is a major cause of morbidity and mortality after renal transplantation. Atorvastatin is a new HMG‐CoA reductase...

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Comparative effects of lovastatin on mammary and prostate oncogenesis in transgenic mouse models

Masa-Aki Shibata, Claudine Kavanaugh, Eiko Shibata, Hideaki Abe, PhuongMai Nguyen, Yoshinori Otsuki, Jane B. Trepel and Jeffrey E. Green.

in Carcinogenesis

March 2003; p ublished online March 2003 .

Journal Article. Subjects: Clinical Cytogenetics and Molecular Genetics. 6238 words.

The effects of lovastatin, a potent inhibitor of HMG CoA reductase, on experimental mammary and prostate oncogenesis, were studied in vitro and in vivo. Lovastatin inhibited cell growth in...

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HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells

Hiromichi Narumiya, Susumu Sasaki, Noriko Kuwahara, Hidekazu Irie, Tetsuro Kusaba, Hisako Kameyama, Keiichi Tamagaki, Tsuguru Hatta, Kazuo Takeda and Hiroaki Matsubara.

in Cardiovascular Research

November 2004; p ublished online November 2004 .

Journal Article. Subjects: Cardiovascular Medicine. 3912 words.


Objective: Klotho is thought to play a critical role in the development of age-related disorders including arteriosclerosis. Statins...

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Simvastatin Suppresses Leptin Expression in 3T3-L1 Adipocytes <i>via</i> Activation of the Cyclic AMP–PKA Pathway Induced by Inhibition of Protein Prenylation

Toyonobu Maeda and Noboru Horiuchi.

in The Journal of Biochemistry

June 2009; p ublished online March 2009 .

Journal Article. Subjects: Biochemistry. 6254 words.

Simvastatin inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, which catalyses conversion of HMG-CoA to mevalonate, a rate-limiting step in cholesterol synthesis. We...

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Associations of Statin Use With Colorectal Cancer Recurrence and Mortality in a Danish Cohort

Timothy L. Lash, Anders H. Riis, Eva B. Ostenfeld, Rune Erichsen, Mogens Vyberg, Thomas P. Ahern and Ole Thorlacius-Ussing.

in American Journal of Epidemiology

September 2017; p ublished online March 2017 .

Journal Article. Subjects: Public Health and Epidemiology. 4698 words.


In earlier studies of the influence of hydroxymethylglutaryl-coenzyme A reductase inhibitors (also known as statins) on colorectal cancer prognosis,...

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Statins in the treatment of chronic heart failure: Biological and clinical considerations

Pim van der Harst, Adriaan A. Voors, Wiek H. van Gilst, Michael Böhm and Dirk J. van Veldhuisen.

in Cardiovascular Research

August 2006; p ublished online August 2006 .

Journal Article. Subjects: Cardiovascular Medicine. 8233 words.


Patients with increased cholesterol levels are at increased risk to experience cardiovascular events and to die from vascular disease. Statins have...

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Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion

Chunyu Zheng, Veronica Azcutia, Elena Aikawa, Jose-Luiz Figueiredo, Kevin Croce, Hiroyuki Sonoki, Frank M. Sacks, Francis W. Luscinskas and Masanori Aikawa.

in European Heart Journal

February 2013; p ublished online August 2012 .

Journal Article. Subjects: Cardiovascular Medicine. 4513 words.


Activation of vascular endothelial cells (ECs) contributes importantly to inflammation and atherogenesis. We previously reported that apolipoprotein...

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Statin therapy of calcific aortic stenosis: hype or hope?

Volker Liebe, Martina Brueckmann, Martin Borggrefe and Jens J. Kaden.

in European Heart Journal

April 2006; p ublished online January 2006 .

Journal Article. Subjects: Cardiovascular Medicine. 4668 words.

Calcific aortic stenosis, with a prevalence of 3–9%, is the most frequent heart valve disease and the main cause for valve replacement in patients over 60 years of age. Once thought to be...

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