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HMG-CoA

Overview page. Subjects: Chemistry.

abbr. for hydroxymethylglutaryl‐CoA.

See overview in Oxford Index

HMG CoA reductase inhibitors

David A. Bender.

in A Dictionary of Food and Nutrition

January 2009; p ublished online January 2009 .

Reference Entry. Subjects: Cookery, Food, and Drink. 26 words.

Drugs which inhibit the enzyme hydroxymethylglutaryl CoA (HMG CoA) reductase, the controlling enzyme of cholesterol synthesis, used

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HMG CoA reductase inhibitors

David A. Bender.

in A Dictionary of Food and Nutrition

P ublished online January 2014 .

Reference Entry. Subjects: Cookery, Food, and Drink. 26 words.

Drugs which inhibit the enzyme hydroxymethylglutaryl CoA (HMG CoA) reductase, the controlling enzyme of cholesterol synthesis, used

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Statins: HMG-CoA Reductase Inhibitors

Jason Choi and John G. Augoustides.

in Pharmacology in Anesthesia Practice

January 2013; p ublished online September 2013 .

Chapter. Subjects: Anaesthetics; Clinical Pharmacology and Therapeutics. 832 words.

This chapter discusses Statins: HMG-CoA Reductase Inhibitors, including Lovastatin, Pravastatin, Simvastatin, Atorvastatin, and Fluvastatin.

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HMG CoA reductase inhibition reduces sarcolemmal Na<sup>+</sup>–K<sup>+</sup> pump density

David F Gray, Henning Bundgaard, Peter S Hansen, Kerrie A Buhagiar, Anastasia S Mihailidou, Wendy Jessup, Keld Kjeldsen and Helge H Rasmussen.

in Cardiovascular Research

August 2000; p ublished online August 2000 .

Journal Article. Subjects: Cardiovascular Medicine. 4797 words.

Abstract

Objectives: HMG CoA reductase inhibitors reduce cellular availability of mevalonate, a precursor in cholesterol synthesis. Since the...

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Pre- and Postnatal Toxicity of the HMG-CoA Reductase Inhibitor Atorvastatin in Rats

J. W. Henck, W. R. Craft, A. Black, J. Colgin and J. A. Anderson.

in Toxicological Sciences

January 1998; p ublished online January 1998 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

Atorvastatin is a potent inhibitor of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate and constitutes the...

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Potential use of HMG-CoA reductase inhibitors (statins) as radioprotective agents

Gerhard Fritz, Christian Henninger and Johannes Huelsenbeck.

in British Medical Bulletin

March 2011; p ublished online January 2011 .

Journal Article. Subjects: Medicine and Health. 3036 words.

HMG-CoA reductase inhibitors (statins) are widely used in the therapy of hypercholesterolemia. Apart from their lipid-lowering activity, they have pleiotropic effects that are attributed to...

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Statins (HMG-CoA reductase inhibitors) reduce CD40 expression in human vascular cells

Flore Mulhaupt, Christian M Matter, Brenda R Kwak, Graziano Pelli, Niels R Veillard, Fabienne Burger, Pierre Graber, Thomas F Lüscher and François Mach.

in Cardiovascular Research

September 2003; p ublished online September 2003 .

Journal Article. Subjects: Cardiovascular Medicine. 5075 words.

Abstract

Objective: HMG-CoA reductase inhibitors (statins) possess anti-inflammatory and immunomodulatory properties that are independent of...

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HMG-CoA reductase inhibitor attenuates experimental autoimmune myocarditis through inhibition of T cell activation

Ryoko Wakizono Azuma, Jun-ichi Suzuki, Masahito Ogawa, Hideki Futamatsu, Noritaka Koga, Yasuyuki Onai, Hisanori Kosuge and Mitsuaki Isobe.

in Cardiovascular Research

December 2004; p ublished online December 2004 .

Journal Article. Subjects: Cardiovascular Medicine. 4124 words.

Abstract

Objective: This study tested the hypothesis that 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitor affects T...

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HMG‐CoA reductase inhibitor ameliorates diabetic nephropathy by its pleiotropic effects in rats

Hitomi Usui, Kenichi Shikata, Mitsuhiro Matsuda, Shinichi Okada, Daisuke Ogawa, Tetsuji Yamashita, Kazuyuki Hida, Minoru Satoh, Jun Wada and Hirofumi Makino.

in Nephrology Dialysis Transplantation

February 2003; p ublished online February 2003 .

Journal Article. Subjects: Nephrology. 3968 words.

Background. An inflammatory process may be one of the critical factors that contribute to the development of diabetic nephropathy (DN). We reported previously that intercellular...

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Fertility and General Reproduction Studies in Rats with the HMG-CoA Reductase Inhibitor, Atorvastatin

LORI A. DOSTAL, LLOYD R. WHITFIELD and JOHN A. ANDERSON.

in Toxicological Sciences

August 1996; p ublished online August 1996 .

Journal Article. Subjects: Medical Toxicology; Toxicology (Non-medical). 0 words.

Fertility and reproduction studies were conducted in rats with the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, atorvastatin. Male rats received vehicle (0.5%...

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