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PCGF

Overview page. Subjects: Medicine and Health.

A transcriptional repressor (polycomb group RING finger protein 2, 344 aa) involved in polycomb repressive complex 1 (PRC1). It has tumour suppressor activity and may play a role in control...

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PCGF

Overview page. Subjects: Medicine and Health.

A transcriptional repressor (polycomb group RING finger protein 2, 344 aa) involved in polycomb repressive complex 1 (PRC1). It has tumour suppressor activity and may play a role in control...

See overview in Oxford Index

PCGF

John Lackie.

in A Dictionary of Biomedicine

January 2010; p ublished online January 2010 .

Reference Entry. Subjects: Clinical Medicine. 72 words.

A transcriptional repressor (polycomb group RING finger protein 2, 344 aa) involved in *polycomb repressive complex 1 (PRC1). It

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polycomb repressive complexes

Overview page. Subjects: Medicine and Health.

Multiprotein complexes involving products of the polycomb group (PcG) genes which were initially identified as regulators of homeotic genes in Drosophila and are implicated in regulation of...

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tumour suppressor

Overview page. Subjects: Medicine and Health.

Generally a gene (antioncogene, cancer susceptibility gene) encoding a negative regulator of the cell cycle, e.g. an inhibitor of a growth factor signalling system, that must be mutated or...

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Overexpression of microRNAs from the <i>Gtl2</i>-<i>Rian</i> locus contributes to postnatal death in mice

Soichiro Kumamoto, Nozomi Takahashi, Kayo Nomura, Makoto Fujiwara, Megumi Kijioka, Yoshinobu Uno, Yoichi Matsuda, Yusuke Sotomaru and Tomohiro Kono.

in Human Molecular Genetics

October 2017; p ublished online June 2017 .

Journal Article. Subjects: Genetics and Genomics. 6365 words.

Abstract

The Dlk1-Dio3 imprinted domain functions in embryonic development but the roles of noncoding RNAs expressed from this domain remain unclear. We...

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