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Pax-6 genes

Overview page. Subjects: Genetics and Genomics.

A subset of Pax genes (q.v.) that encode evolutionarily conserved transcription factors essential for eye development in insect and mammalian species. In Drosophila, the Pax-6 genes (q.v.)...

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Pax-6 genes

Overview page. Subjects: Genetics and Genomics.

A subset of Pax genes (q.v.) that encode evolutionarily conserved transcription factors essential for eye development in insect and mammalian species. In Drosophila, the Pax-6 genes (q.v.)...

See overview in Oxford Index

Evolution of the Vertebrate Pax4/6 Class of Genes with Focus on Its Novel Member, the <i>Pax10</i> Gene

Nathalie Feiner, Axel Meyer and Shigehiro Kuraku.

in Genome Biology and Evolution

P ublished online June 2014 .

Journal Article. Subjects: Bioinformatics and Computational Biology; Evolutionary Biology; Genetics and Genomics. 10321 words.

The members of the paired box (Pax) family regulate key developmental pathways in many metazoans as tissue-specific transcription factors. Vertebrate genomes typically possess nine Pax gene...

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Identification of <i>in vivo</i> DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development

Jian Sun, Shira Rockowitz, Qing Xie, Ruth Ashery-Padan, Deyou Zheng and Ales Cvekl.

in Nucleic Acids Research

August 2015; p ublished online July 2015 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 11260 words.

The transcription factor Pax6 is comprised of the paired domain (PD) and homeodomain (HD). In the developing forebrain, Pax6 is expressed in ventricular zone precursor cells and in specific...

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Regulation of c-<i>maf</i> gene expression by Pax6 in cultured cells

Masaharu Sakai, Mohamed S. Serria, Hiromi Ikeda, Kazuhiko Yoshida, Junko Imaki and Shinzo Nishi.

in Nucleic Acids Research

March 2001; p ublished online March 2001 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 6743 words.

c-Maf is a bZip transcription factor expressed in developmental and cellular differentiation processes. Recently, a c-maf knockout mouse model, showing abnormal lens development, has been...

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Functional Analysis of Paired Box Missense Mutations in The <i>PAX6</i> Gene

Hank Kejun Tang, Lian-Yu Chao and Grady F. Saunders.

in Human Molecular Genetics

March 1997; p ublished online March 1997 .

Journal Article. Subjects: Genetics and Genomics. 4552 words.

Mutations in the human PAX6 gene produce various phenotypes, including aniridia, Peters' anomaly, autosomal dominant keratitis and familial foveal dysplasia. The various phenotypes may...

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Evolution of Eye Regression in the Cavefish <i>Astyanax</i>: Apoptosis and the <i>Pax-6</i> Gene<sup>1</sup>

WILLIAM R. JEFFERY and DAVID P. MARTASIAN.

in Integrative and Comparative Biology

September 1998; p ublished online September 1998 .

Journal Article. Subjects: Biological Sciences. 0 words.

SYNOPSIS. The eye is an extraordinary organ in terms of its development and evolution. In cave animals, the eye is sometimes reduced or eliminated as a consequence of adaptation to life in...

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Pax-6 genes

Robert C. King, William D. Stansfield and Pamela K. Mulligan.

in A Dictionary of Genetics

January 2007; p ublished online January 2007 .

Reference Entry. Subjects: Genetics and Genomics. 52 words.

a subset of Pax genes (q.v.) that encode evolutionarily conserved transcription factors essential for eye development in insect

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<i>Pax-6</i> genes

Robert C. King, Pamela K. Mulligan and William D. Stansfield.

in A Dictionary of Genetics

January 2013; p ublished online January 2014 .

Reference Entry. Subjects: Genetics and Genomics. 57 words.

a subset of Pax genes (q.v.) that encode evolutionarily conserved transcription factors essential for eye development in insect

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Activation of the human <i>PAX6</i> gene through the exon 1 enhancer by transcription factors SEF and Sp1

Jessica B. Zheng, Yi-Hong Zhou, Tapati Maity, Warren S.-L. Liao and Grady F. Saunders.

in Nucleic Acids Research

October 2001; p ublished online October 2001 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 5395 words.

PAX6 is a transcription factor that plays a major role in ocular morphogenesis. PAX6 is expressed in the eye, central nervous system and pancreas. Two alternative promoters, P0 and P1, which...

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Functional interactions between alternatively spliced forms of Pax6 in crystallin gene regulation and in haploinsufficiency

Bharesh K. Chauhan, Ying Yang, Květa Cveklová and Aleš Cvekl.

in Nucleic Acids Research

March 2004; p ublished online March 2004 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 8393 words.

Pax6 is essential for development of the eye, olfactory system, brain and pancreas. Haploinsufficiency of Pax6 causes abnormal eye development. Two forms of Pax6 protein, PAX6...

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The Trichoplax <i>PaxB</i> Gene: A Putative Proto-<i>PaxA/B/C</i> Gene Predating the Origin of Nerve and Sensory Cells

Thorsten Hadrys, Rob DeSalle, Sven Sagasser, Nina Fischer and Bernd Schierwater.

in Molecular Biology and Evolution

July 2005; p ublished online April 2005 .

Journal Article. Subjects: Evolutionary Biology; Molecular and Cell Biology. 5330 words.

Pax genes play key regulatory roles in embryonic and sensory organ development in metazoans but their evolution and ancestral functions remain widely unresolved. We have...

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<i>Cladonema radiatum</i>

Robert C. King, Pamela K. Mulligan and William D. Stansfield.

in A Dictionary of Genetics

January 2013; p ublished online January 2014 .

Reference Entry. Subjects: Genetics and Genomics. 45 words.

a hydrozoan jellyfish possessing several light sensitive structures resembling eyes. A gene that is an ortholog of the Pax-6 genes

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Aniridia

Robert C. King, William D. Stansfield and Pamela K. Mulligan.

in A Dictionary of Genetics

January 2007; p ublished online January 2007 .

Reference Entry. Subjects: Genetics and Genomics. 45 words.

a dominant mutation of the Pax-6 gene located at 11p13, which causes defects in the iris, lens, cornea, and retina

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<i>Aniridia</i>

Robert C. King, Pamela K. Mulligan and William D. Stansfield.

in A Dictionary of Genetics

January 2013; p ublished online January 2014 .

Reference Entry. Subjects: Genetics and Genomics. 45 words.

a dominant mutation of the Pax-6 gene located at 11p13, which causes defects in the iris, lens, cornea, and

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Isolation of <i>Cladonema Pax-B</i> Genes and Studies of the DNA-Binding Properties of Cnidarian Pax Paired Domains

Hongmin Sun, Douglas P. Dickinson, John Costello and Wen-Hsiung Li.

in Molecular Biology and Evolution

October 2001; p ublished online October 2001 .

Journal Article. Subjects: Evolutionary Biology; Molecular and Cell Biology. 8435 words.

Pax genes encode nuclear transcription factors that are involved in developmental control. They contain a conserved DNA-binding domain, the paired domain. The DNA-binding...

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Comparative analysis of Pax-6 sequence and expression in the eye development of the blind cave fish Astyanax fasciatus and its epigean conspecific.

M Behrens, T G Langecker, H Wilkens and H Schmale.

in Molecular Biology and Evolution

March 1997; p ublished online March 1997 .

Journal Article. Subjects: Evolutionary Biology; Molecular and Cell Biology. 0 words.

The Pax-6 gene encodes a transcription factor essential for eye development in a wide range of animal phyla. In order to elucidate a possible role of Pax-6 in the eye regression of a blind...

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The human PAX6 mutation database

Alastair Brown, Mark McKie, Veronica van Heyningen and Jane Prosser.

in Nucleic Acids Research

January 1998; p ublished online January 1998 .

Journal Article. Subjects: Chemistry; Biochemistry; Bioinformatics and Computational Biology; Genetics and Genomics; Molecular and Cell Biology. 2105 words.

The Human PAX6 Mutation Database contains details of 94 mutations of the PAX6 gene. A Microsoft Access program is used by the Curator to store, update and search the database entries....

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Pax genes

Overview page. Subjects: Medicine and Health.

A highly conserved family of genes (paired domain genes, paired box genes) encoding transcription factors that are important in pattern formation during development. Pax1 (Hup48) is...

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Small eye (Sey)

Overview page. Subjects: Genetics and Genomics.

A gene in mice and rats that controls eye development. Animals heterozygous for a mutant allele have underdeveloped eyes. Homozygotes lack eyes altogether. Sey, Pax-6, and ey are homologous...

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Transdifferentiation of the retinal pigment epithelia to the neural retina by transfer of the Pax6 transcriptional factor

Noriyuki Azuma, Keiko Tadokoro, Astuko Asaka, Masao Yamada, Yuki Yamaguchi, Hiroshi Handa, Satsuki Matsushima, Takashi Watanabe, Yasuyuki Kida, Toshihiko Ogura, Masaaki Torii, Kenji Shimamura and Masato Nakafuku.

in Human Molecular Genetics

April 2005; p ublished online March 2005 .

Journal Article. Subjects: Genetics and Genomics. 8531 words.

The Pax6 gene plays an important role in eye morphogenesis throughout the animal kingdom. The Pax6 gene and its homologue could form ectopic eyes by targeted expression in Drosophila and Xen...

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