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Thy-1

Overview page. Subjects: Chemistry.

An allelic variable molecule, encoded on mouse chromosome 9, that is present on all T lymphocytes and also occurs in brain. It is a GPI‐anchored membrane glycoprotein of the immunoglobulin...

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Thy-1

Overview page. Subjects: Chemistry.

An allelic variable molecule, encoded on mouse chromosome 9, that is present on all T lymphocytes and also occurs in brain. It is a GPI‐anchored membrane glycoprotein of the immunoglobulin...

See overview in Oxford Index

thy1

Overview page. Subjects: Medicine and Health.

An N-glycosylated, glycophosphatidylinositol (GPI) anchored cell surface protein (CD90, 161 aa) with a single V-like immunoglobulin domain found on T cells, axonal processes, endothelial...

See overview in Oxford Index

thy1

John Lackie.

in A Dictionary of Biomedicine

January 2010; p ublished online January 2010 .

Reference Entry. Subjects: Clinical Medicine. 30 words.

An N-glycosylated, glycophosphatidylinositol (GPI) anchored cell surface protein (CD90, 161 aa) with a single V-like immunoglobulin domain found on

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Thy‐1

Edited by Richard Cammack, Teresa Atwood, Peter Campbell, Howard Parish, Anthony Smith, Frank Vella and John Stirling.

in Oxford Dictionary of Biochemistry and Molecular Biology

January 2006; p ublished online January 2008 .

Reference Entry. Subjects: Biochemistry. 48 words.

an allelic variable molecule, encoded on mouse chromosome 9, that is present on all T lymphocytes and also occurs in

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Podocyte changes upon induction of albuminuria in Thy-1.1 transgenic mice

Bart Smeets, Henry B. P. M. Dijkman, Nathalie A. J. M. te Loeke, Jacco P. H. F. van Son, Eric J. Steenbergen, Karel J. M. Assmann, Jack F. M. Wetzels and Patricia J. T. A. Groenen.

in Nephrology Dialysis Transplantation

December 2003; p ublished online December 2003 .

Journal Article. Subjects: Nephrology. 5488 words.

Background. Thy-1.1 transgenic mice, characterized by ectopic expression of the Thy-1.1 protein on podocytes, spontaneously develop proteinuria and focal glomerulosclerosis...

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Characterization of the interaction between galectin-1 and lymphocyte glycoproteins CD45 and Thy-1

Antony Symons, Douglas N.Cooper and A.Neil Barclay.

in Glycobiology

June 2000; p ublished online June 2000 .

Journal Article. Subjects: Carbohydrates. 3675 words.

Galectin-1 is a sugar binding protein specific for β-galactosides and not requiring metal ions for binding activity. It exists as a soluble protein which forms a noncovalent homodimer and is...

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CD4<sup>+</sup>Thy1<sup>−</sup> thymocytes with a T<sub>h</sub>-type 2 cytokine response

Douglas M. Cerasoli, Garnett Kelsoe and Marcella Sarzotti.

in International Immunology

February 2001; p ublished online February 2001 .

Journal Article. Subjects: Immunology; Biological Sciences. 5595 words.

We have identified a small subset of CD3+, CD4+, CD8 thymocytes that do not express Thy1 (CD90). This Thy1 subset represents 1–3.7% of the total number of thymocytes in a naive mouse. CD4+null...

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Glomerular activin A overexpression is linked to fibrosis in anti-Thy1 glomerulonephritis

Jens Gaedeke, Torsten Boehler, Klemens Budde, Hans-H. Neumayer and Harm Peters.

in Nephrology Dialysis Transplantation

February 2005; p ublished online February 2005 .

Journal Article. Subjects: Nephrology. 5393 words.

Background. Activin A, a member of the transforming growth factor-β (TGF-β) superfamily of proteins, shares many biological features with the pro-fibrotic cytokine TGF-β1, which...

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Thy-1 antigen

Overview page. Subjects: Genetics and Genomics.

An antigen on the plasma membrane of thymocytes (q.v.) that can be used to distinguish them from other lymphocyte groups.

See overview in Oxford Index

Thy-1 antigen

Robert C. King, William D. Stansfield and Pamela K. Mulligan.

in A Dictionary of Genetics

January 2007; p ublished online January 2007 .

Reference Entry. Subjects: Genetics and Genomics. 22 words.

an antigen on the plasma membrane of thymocytes (q.v.) that can be used to distinguish them from other

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Thy-1 antigen

Robert C. King, Pamela K. Mulligan and William D. Stansfield.

in A Dictionary of Genetics

January 2013; p ublished online January 2014 .

Reference Entry. Subjects: Genetics and Genomics. 22 words.

an antigen on the plasma membrane of thymocytes (q.v.) that can be used to distinguish them from other

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Endothelial progenitor cell-derived extracellular vesicles protect from complement-mediated mesangial injury in experimental anti-Thy1.1 glomerulonephritis

Vincenzo Cantaluppi, Davide Medica, Claudio Mannari, Giulia Stiaccini, Federico Figliolini, Sergio Dellepiane, Alessandro Domenico Quercia, Massimiliano Migliori, Vincenzo Panichi, Luca Giovannini, Stefania Bruno, Ciro Tetta, Luigi Biancone and Giovanni Camussi.

in Nephrology Dialysis Transplantation

March 2015; p ublished online December 2014 .

Journal Article. Subjects: Nephrology. 5712 words.

Background

Endothelial progenitor cells (EPCs) are known to induce tissue repair by paracrine mechanisms including the release of growth factors and...

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Expression of CX3CL1/fractalkine by mesangial cells <i>in vitro</i> and in acute anti-Thy1 glomerulonephritis in rats

Yung-Ming Chen, Mi-I Hu-Tsai, Shuei-Liong Lin, Tun-Jun Tsai and Bor-Shen Hsieh.

in Nephrology Dialysis Transplantation

December 2003; p ublished online December 2003 .

Journal Article. Subjects: Nephrology. 4915 words.

Background. Mesangial cells (MCs) can promote glomerular macrophage accumulation in glomerulonephritis through production of a variety of chemokines. This study investigated the...

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Angiotensin converting enzyme inhibition prevents development of collapsing focal segmental glomerulosclerosis in Thy-1.1 transgenic mice

Bart Smeets, Mark L. M. Steenbergen, Henry B. P. M. Dijkman, Kiek N. Verrijp, Nathalie A. J. M. te Loeke, Jan Aten, Eric J. Steenbergen and Jack F. M. Wetzels.

in Nephrology Dialysis Transplantation

November 2006; p ublished online September 2006 .

Journal Article. Subjects: Nephrology. 5221 words.

Background. Thy-1.1 transgenic mice develop hypercellular focal and segmental glomerulosclerosis (FSGS) lesions that mimic human collapsing FSGS, in 7 days after injection with...

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The glycan processing and site occupancy of recombinant Thy-1 is markedly affected by the presence of a glycosylphosphatidylinositol anchor

Mercy Devasahayam, Peter D. Catalino, Pauline M. Rudd, Raymond A. Dwek and A. Neil Barclay.

in Glycobiology

December 1999; p ublished online December 1999 .

Journal Article. Subjects: Carbohydrates. 4830 words.

Thy-1 is a cell surface glycoprotein containing three N-linked glycosylation sites and a glycosylphosphatidylinositol (GPI) anchor. The effect of the anchor on its N-linked glycosylation...

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The appearance of Thy-1<sup>−</sup> donor T cells in the peripheral circulation 3–6 weeks after bone marrow transplantation suggests an extrathymic origin

Rui-kun Zhong, Albert D. Donnenberg, Linette Edison and David E. Harrison.

in International Immunology

February 1996 .

Journal Article. Subjects: Immunology; Biological Sciences. 0 words.

Donor and host T cells were distinguished by T cell antigen marker Thy-1 isotype and cytoplasmic isozyme Gpi-1 in thisstudy of bone marrow transplantation between congenic mice. During the...

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Comparison of Fas- versus perforin-mediated pathways of cytotoxicity in TCR- and Thy-1-activated murine T cells

Hidefumi Kojima, Masahiro Toda and Michail V. Sitkovsky.

in International Immunology

March 2000; p ublished online March 2000 .

Journal Article. Subjects: Immunology; Biological Sciences. 7349 words.

T cell-mediated cytotoxicity can be triggered by cross-linking of TCR or Thy-1 surface proteins. While the TCR-triggered signaling initiates both perforin- and Fas ligand...

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Acute glomerular upregulation of ornithine decarboxylase is not essential for mesangial cell proliferation and matrix expansion in anti-Thy-1-nephritis

Markus Ketteler, Ralf Westenfeld, Alexander Gawlik, Emile de Heer and Armin Distler.

in Nephrology Dialysis Transplantation

January 2000; p ublished online January 2000 .

Journal Article. Subjects: Nephrology. 3897 words.

Background. Pathways of l-arginine metabolism including nitric oxide, agmatine and polyamine synthesis are upregulated during glomerular inflammation in experimental...

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Follicles in gut-associated lymphoid tissues create preferential survival niches for follicular T<sub>h</sub> cells escaping Thy-1-specific depletion in mice

Martina Mihalj, Zoltán Kellermayer and Peter Balogh.

in International Immunology

July 2013; p ublished online February 2013 .

Journal Article. Subjects: Immunology; Biological Sciences. 7415 words.

Although a substantial number of T cells may escape depletion following in vivo mAb treatment in patients undergoing immunosuppression, their specific tissue location and phenotypic...

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The leukotriene B4 receptor antagonist ONO-4057 inhibits mesangioproliferative changes in anti-Thy-1 nephritis

Yukihiko Kawasaki, Mieko Tanji, Kei Takano, Yutaka Fukuda, Masato Isome, Ruriko Nozawa, Hitoshi Suzuki and Mitsuaki Hosoya.

in Nephrology Dialysis Transplantation

December 2005; p ublished online October 2005 .

Journal Article. Subjects: Nephrology. 3145 words.

Objective. ONO-4057 is a specific leukotriene B4 (LTB4) receptor antagonist which inhibits human neutrophil aggregation, chemotaxis and degranulation induced by LTB4. This study...

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